Gpr15lg G protein-coupled receptor 15 ligand [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpr15lgprovided by RGD
Official Full Name: G protein-coupled receptor 15 ligandprovided by RGD
Primary source: RGD:1566160
See related: Ensembl:ENSRNOG00000043342 AllianceGenome:RGD:1566160
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpr15l
Summary: Predicted to enable chemokine activity. Predicted to be involved in several processes, including defense response to other organism; lymphocyte chemotaxis; and negative regulation of cell cycle G1/S phase transition. Predicted to be located in extracellular region. Orthologous to human C10orf99 (chromosome 10 open reading frame 99). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 126.2), Spleen (RPKM 60.9) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (12888528..12896134, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (12868270..12875876, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (14352998..14360604, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables chemokine activity	ISO Inferred from Sequence Orthology more info
enables chemokine activity	ISS Inferred from Sequence or Structural Similarity more info
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to fungus	ISO Inferred from Sequence Orthology more info
involved_in lymphocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in lymphocyte chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in mast cell degranulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell division	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of keratinocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein GPR15LG

Names: hypothetical gene supported by AF152002; protein GPR15 ligand; protein GPR15L; secreted protein C10orf99 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106063.2 → NP_001099533.2 protein GPR15LG precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

D3ZKM3

Related

ENSRNOP00000060855.2, ENSRNOT00000065460.4

Conserved Domains (1) summary

pfam15854
Location:1 → 76

DUF4725; Domain of unknown function (DUF4725)