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    Gpr68 G protein-coupled receptor 68 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314386, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Gpr68provided by RGD
    Official Full Name
    G protein-coupled receptor 68provided by RGD
    Primary source
    RGD:1309559
    See related
    Ensembl:ENSRNOG00000046309 AllianceGenome:RGD:1309559
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in cellular response to pH. Predicted to act upstream of or within negative regulation of monocyte differentiation; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and positive regulation of osteoclast development. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 2A6. Orthologous to human GPR68 (G protein-coupled receptor 68). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 47.3), Spleen (RPKM 36.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpr68 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (125865205..125895674, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (120135620..120166089, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (124874151..124903949, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479467 Neighboring gene D-glutamate cyclase Neighboring gene uncharacterized LOC120103602 Neighboring gene coiled-coil domain containing 88C Neighboring gene protein phosphatase 4, regulatory subunit 3A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. GPR68 Improves Nerve Damage and Myelination in an Immature Rat Model Induced by Sevoflurane Anesthesia by Activating cAMP/CREB to Mediate BDNF. Zhao D, et al. ACS Chem Neurosci, 2022 Feb 2. PMID 35025202
    2. Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis. Yang M, et al. J Biol Chem, 2006 Aug 18. PMID 16787916
    3. Abnormalities in osteoclastogenesis and decreased tumorigenesis in mice deficient for ovarian cancer G protein-coupled receptor 1. Li H, et al. PLoS One, 2009 May 28. PMID 19479052, Free PMC Article
    4. Proton receptor GPR68 expression in dendritic-cell-like S100β-positive cells of rat anterior pituitary gland: GPR68 induces interleukin-6 gene expression in extracellular acidification. Horiguchi K, et al. Cell Tissue Res, 2014 Nov. PMID 25129106
    5. Deficiency of proton-sensing ovarian cancer G protein-coupled receptor 1 attenuates glucose-stimulated insulin secretion. Nakakura T, et al. Endocrinology, 2012 Sep. PMID 22733973

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPR68 Improves Nerve Damage and Myelination in an Immature Rat Model Induced by Sevoflurane Anesthesia by Activating cAMP/CREB to Mediate BDNF.
      Title: GPR68 Improves Nerve Damage and Myelination in an Immature Rat Model Induced by Sevoflurane Anesthesia by Activating cAMP/CREB to Mediate BDNF.
    2. S100beta-positive dendritic-like cells can sense an increase in extracellular protons via GPR68 and respond by the production of IL-6 in order to suppress the up-regulation of Pomc expression.
      Title: Proton receptor GPR68 expression in dendritic-cell-like S100β-positive cells of rat anterior pituitary gland: GPR68 induces interleukin-6 gene expression in extracellular acidification.
    3. OGR1 is expressed early during osteoclastogenesis both in vivo and in vitro and plays a role in osteoclast differentiation.
      Title: Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to pH ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of osteoclast development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of osteoclast development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ovarian cancer G-protein coupled receptor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108049.1 → NP_001101519.1  ovarian cancer G-protein coupled receptor 1

      See identical proteins and their annotated locations for NP_001101519.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473982
      UniProtKB/TrEMBL
      A6JEH9, D3ZSW1
      Related
      ENSRNOP00000091078.1, ENSRNOT00000113620.1
      Conserved Domains (1) summary
      cd15367
      Location:32 → 307
      7tmA_GPR68_OGR1; G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      125865205..125895674 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112353.2 → XP_038968281.1  ovarian cancer G-protein coupled receptor 1 isoform X1

      UniProtKB/TrEMBL
      A6JEH9, D3ZSW1
      Related
      ENSRNOP00000064586.1
      Conserved Domains (1) summary
      cd15367
      Location:32 → 307
      7tmA_GPR68_OGR1; G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_039112352.2 → XP_038968280.1  ovarian cancer G-protein coupled receptor 1 isoform X1

      UniProtKB/TrEMBL
      A6JEH9, D3ZSW1
      Related
      ENSRNOP00000080372.1
      Conserved Domains (1) summary
      cd15367
      Location:32 → 307
      7tmA_GPR68_OGR1; G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version

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