Slc30a2 solute carrier family 30 member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc30a2provided by RGD
Official Full Name: solute carrier family 30 member 2provided by RGD
Primary source: RGD:3707
See related: Ensembl:ENSRNOG00000054142 AllianceGenome:RGD:3707
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Znt2; ZnT-2
Summary: The protein encoded by this gene is a zinc transporter. It is localized in the vesicles and suggested to protect the cells from zinc toxicity by facilitating vesicular sequestration. Alternatively spliced transcript variants have been found for this gene, one of which initiates translation from a non-AUG (CUG) start codon. [provided by RefSeq, Jul 2008]
Expression: Biased expression in Kidney (RPKM 90.2), Testes (RPKM 6.1) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (151843451..151855674)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (146559733..146571957)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (152559577..152571800)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

expression of the zinc transporter in ventral prostate (VP) of aged rats (21 months) was approximately 21-fold higher than that in VP of young rats (4 months), and zinc levels in VP of young rats increased significantly compared with that in aged rats.
Title: Castration- and aging-induced changes in the expression of zinc transporter and metallothionein in rat prostate.
The results indicate that ZnT2 may play a significant role in the maintenance of zinc homeostasis in the prostate.
Title: Zinc transporter expression profiles in the rat prostate following alterations in dietary zinc.
The upregulation of ZnT1, ZnT2, and ZnT4 was to decrease the cytosolic zinc levels caused by NO after transient occlusion of the CCA.
Title: The increase in zinc levels and upregulation of zinc transporters are mediated by nitric oxide in the cerebral cortex after transient ischemia in the rat.
There were no differences between the mRNA expression levels of ZnT family members in undifferentiated Rcho-1 cells and differentiated Rcho-1 cells.
Title: Expression profiles of zinc transporters in rodent placental models.
Expression of zinc transporter-2 in lateral and dorsal prostate was unaffected by castration. Factors regulating zinc homeostasis other than zinc transporters are involved in lowering zinc content after castration in rat prostate.
Title: High-level expression of zinc transporter-2 in the rat lateral and dorsal prostate.
Transfection and mutation studies show that translation initiates at a non-AUG (CUG) start codon.
Title: ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration.

Submit: New GeneRIF Correction

General gene information

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Markers

RH140188 (e-PCR)
- UniSTS:222267

RH133009 (e-PCR)
- UniSTS:216292

PMC61071P1 (e-PCR)
- UniSTS:273407

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables zinc ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables zinc ion transmembrane transporter activity	TAS Traceable Author Statement more info
enables zinc:proton antiporter activity	IC Inferred by Curator more info	PubMed
enables zinc:proton antiporter activity	IEA Inferred from Electronic Annotation more info
enables zinc:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables zinc:proton antiporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in intracellular zinc ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to zinc ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in zinc ion import into lysosome	IEA Inferred from Electronic Annotation more info
involved_in zinc ion import into lysosome	ISO Inferred from Sequence Orthology more info
involved_in zinc ion import into mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in zinc ion import into mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in zinc ion import into mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
involved_in zinc ion import into organelle	ISO Inferred from Sequence Orthology more info
involved_in zinc ion import into secretory vesicle	ISO Inferred from Sequence Orthology more info
involved_in zinc ion import into zymogen granule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zinc ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in zinc ion transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome membrane	TAS Traceable Author Statement more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in secretory vesicle	ISO Inferred from Sequence Orthology more info
located_in secretory vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in transport vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in zymogen granule membrane	IEA Inferred from Electronic Annotation more info
located_in zymogen granule membrane	ISO Inferred from Sequence Orthology more info
located_in zymogen granule membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: proton-coupled zinc antiporter SLC30A2

Names: solute carrier family 30 (zinc transporter), member 2; zinc transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083122.1 → NP_001076591.1 proton-coupled zinc antiporter SLC30A2 isoform 1

See identical proteins and their annotated locations for NP_001076591.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

BC061997, CB778290

UniProtKB/TrEMBL

B4F7D8, Q6P6V5

Related

ENSRNOP00000072908.1, ENSRNOT00000082245.2

Conserved Domains (1) summary

TIGR01297
Location:79 → 357

CDF; cation diffusion facilitator family transporter
NM_012890.2 → NP_037022.1 proton-coupled zinc antiporter SLC30A2 isoform 2

See identical proteins and their annotated locations for NP_037022.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) has a different 5' end compared to transcript variant 1, and initiates translation from a non-AUG (CUG) start codon. The resulting isoform (2) is shorter and has a different N-terminus compared to isoform 1.

Source sequence(s)

BC061997, U50927

UniProtKB/Swiss-Prot

Q62941

UniProtKB/TrEMBL

Q6P6V5

Conserved Domains (2) summary

TIGR01297
Location:66 → 344

CDF; cation diffusion facilitator family transporter

pfam01545
Location:66 → 265

Cation_efflux; Cation efflux family