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    Enpp5 ectonucleotide pyrophosphatase/phosphodiesterase family member 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316249, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Enpp5provided by RGD
    Official Full Name
    ectonucleotide pyrophosphatase/phosphodiesterase family member 5provided by RGD
    Primary source
    RGD:1359199
    See related
    Ensembl:ENSRNOG00000010232 AllianceGenome:RGD:1359199
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Npp5; E-NPP 5
    Summary
    Predicted to enable NAD+ diphosphatase activity and zinc ion binding activity. Involved in cell communication. Located in plasma membrane. Orthologous to human ENPP5 (ectonucleotide pyrophosphatase/phosphodiesterase family member 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 570.8), Kidney (RPKM 371.8) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Enpp5 in Genome Data Viewer
    Location:
    9q13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (24407574..24415029, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (16910187..16917633, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (19469276..19476684, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480346 Neighboring gene uncharacterized LOC102555783 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 4 Neighboring gene regulator of calcineurin 2 Neighboring gene uncharacterized LOC120094639 Neighboring gene cytochrome P450, family 39, subfamily a, polypeptide 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of nucleotide pyrophosphatase-5 as an oligomannosidic glycoprotein in rat brain. Ohe Y, et al. Biochem Biophys Res Commun, 2003 Sep 5. PMID 12927778
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NPP-5 is a neural oligomannosidic glycoprotein that may participate in neural cell communications.
      Title: Characterization of nucleotide pyrophosphatase-5 as an oligomannosidic glycoprotein in rat brain.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC105517

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAD+ diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell communication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ectonucleotide pyrophosphatase/phosphodiesterase family member 5
    Names
    E-NPP5
    NPP-5
    ectonucleotide pyrophosphatase/phosphodiesterase 5
    NP_001012762.1
    XP_006244669.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012744.1 → NP_001012762.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 5 precursor

      See identical proteins and their annotated locations for NP_001012762.1

      Status: PROVISIONAL

      Source sequence(s)
      BC090331
      UniProtKB/Swiss-Prot
      P84039, Q5EAN9
      UniProtKB/TrEMBL
      A6JJ21
      Related
      ENSRNOP00000013703.4, ENSRNOT00000013703.7
      Conserved Domains (2) summary
      pfam01663
      Location:30 → 342
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:28 → 382
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      24407574..24415029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244607.5 → XP_006244669.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform X1

      See identical proteins and their annotated locations for XP_006244669.1

      UniProtKB/Swiss-Prot
      P84039, Q5EAN9
      UniProtKB/TrEMBL
      A6JJ21
      Conserved Domains (2) summary
      pfam01663
      Location:30 → 342
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:28 → 382
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P84039.2 GenPept UniProtKB/Swiss-Prot:P84039

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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