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    Nt5c3b 5'-nucleotidase, cytosolic IIIB [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360629, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Nt5c3bprovided by RGD
    Official Full Name
    5'-nucleotidase, cytosolic IIIBprovided by RGD
    Primary source
    RGD:1359229
    See related
    Ensembl:ENSRNOG00000016475 AllianceGenome:RGD:1359229
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nt5c3l
    Summary
    Predicted to enable 5'-nucleotidase activity; magnesium ion binding activity; and nucleotide binding activity. Predicted to be involved in dephosphorylation and nucleotide metabolic process. Predicted to be active in cytoplasm. Orthologous to human NT5C3B (5'-nucleotidase, cytosolic IIIB). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 108.1), Adrenal (RPKM 91.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nt5c3b in Genome Data Viewer
    Location:
    10q31
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (85859509..85876731, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (85358483..85376340, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88338700..88356538, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480874 Neighboring gene prolyl 3-hydroxylase family member 4 Neighboring gene FKBP prolyl isomerase 10 Neighboring gene kelch-like family member 10 Neighboring gene kelch-like family member 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93839

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables 5'-nucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-nucleotidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    7-methylguanosine phosphate-specific 5'-nucleotidase
    Names
    5'-nucleotidase, cytosolic III-like
    7-methylguanosine nucleotidase
    N(7)-methylguanylate 5'-phosphatase
    cN-III-like protein
    cytosolic 5'-nucleotidase 3B
    cytosolic 5'-nucleotidase III-like protein
    cytosolic 5-nucleotidase III-like protein-like
    NP_001007724.2
    XP_008766306.1
    XP_017452886.1
    XP_063125502.1
    XP_063125503.1
    XP_063125504.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007723.2 → NP_001007724.2  7-methylguanosine phosphate-specific 5'-nucleotidase

      See identical proteins and their annotated locations for NP_001007724.2

      Status: VALIDATED

      Source sequence(s)
      AW527524, BC078963
      UniProtKB/Swiss-Prot
      F8WG43, Q6AYP7
      Related
      ENSRNOP00000022430.3, ENSRNOT00000022430.7
      Conserved Domains (1) summary
      pfam05822
      Location:44 → 289
      UMPH-1; Pyrimidine 5'-nucleotidase (UMPH-1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      85859509..85876731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008768084.4 → XP_008766306.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X4

      Conserved Domains (1) summary
      pfam05822
      Location:44 → 256
      UMPH-1; Pyrimidine 5'-nucleotidase (UMPH-1)

    2. XM_017597397.3 → XP_017452886.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X2

      UniProtKB/Swiss-Prot
      F8WG43, Q6AYP7
      Conserved Domains (1) summary
      pfam05822
      Location:44 → 289
      UMPH-1; Pyrimidine 5'-nucleotidase (UMPH-1)

    3. XM_063269432.1 → XP_063125502.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X1

      UniProtKB/TrEMBL
      A0A8L2R1G3

    4. XM_063269434.1 → XP_063125504.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X5

    5. XM_063269433.1 → XP_063125503.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYP7.2 GenPept UniProtKB/Swiss-Prot:Q6AYP7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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