Slc52a2 solute carrier family 52 member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc52a2provided by RGD
Official Full Name: solute carrier family 52 member 2provided by RGD
Primary source: RGD:1560410
See related: Ensembl:ENSRNOG00000032561 AllianceGenome:RGD:1560410
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: rRFT1; Gpr172a; Gpr172b; RGD1560410
Summary: Enables riboflavin transmembrane transporter activity. Involved in riboflavin transport. Is integral component of plasma membrane. Human ortholog(s) of this gene implicated in Brown-Vialetto-Van Laere syndrome 2 and riboflavin deficiency. Orthologous to several human genes including SLC52A2 (solute carrier family 52 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 50.5), Adrenal (RPKM 33.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (110126632..110146647)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (108246003..108267642)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (117605038..117608460)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The obtained results suggested the involvement of riboflavin transporters (SLC52A/RFVT) at the outer BRB, and this is supported by the expression and knockdown analyses of rRFVT2 (Slc52a2) and rRFVT3 (Slc52a3).
Title: Riboflavin transport mediated by riboflavin transporters (RFVTs/SLC52A) at the rat outer blood-retinal barrier.
The function and inhibition profile suggested the involvement of riboflavin transporter 2 in riboflavin transport at the inner BRB, and this is supported by expression and knockdown analysis of rRFVT2 (Slc52a2) and rRFVT3 (Slc52a3) in TR-iBRB2 cells.
Title: Blood-to-retina transport of riboflavin via RFVTs at the inner blood-retinal barrier.
Intestinal riboflavin uptake process undergoes differentiation-dependent upregulation and suggest that this is mediated (at least in part) via transcriptional mechanisms of SLC52A1 and SLC52A3.
Title: Differentiation-dependent regulation of intestinal vitamin B(2) uptake: studies utilizing human-derived intestinal epithelial Caco-2 cells and native rat intestine.
Identification/characterization riboflavin trasporter (RFT1) as a novel riboflavin transporter.
Title: Identification and functional characterization of a novel human and rat riboflavin transporter, RFT1.

Submit: New GeneRIF Correction

General gene information

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Markers

AI556833 (e-PCR)
- UniSTS:244740

D15Ertd747e (e-PCR), detects polymorphism
- UniSTS:167178

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 4-hydroxybutyrate receptor activity	ISO Inferred from Sequence Orthology more info
enables 4-hydroxybutyrate receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables riboflavin transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables riboflavin transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables riboflavin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in flavin adenine dinucleotide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in riboflavin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in riboflavin transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in riboflavin transport	IDA Inferred from Direct Assay more info	PubMed
involved_in riboflavin transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 52, riboflavin transporter, member 2

Names: G protein-coupled receptor 172A; G protein-coupled receptor 172B; porcine endogenous retrovirus A receptor 2; riboflavin transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109670.1 → NP_001103140.1 solute carrier family 52, riboflavin transporter, member 2

See identical proteins and their annotated locations for NP_001103140.1

Status: PROVISIONAL

Source sequence(s)

CH473950

UniProtKB/Swiss-Prot

A3KN99, B5MEV3

Conserved Domains (1) summary

pfam06237
Location:278 → 375

DUF1011; Protein of unknown function (DUF1011)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

110126632..110146647

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263875.1 → XP_063119945.1 solute carrier family 52, riboflavin transporter, member 2 isoform X2

UniProtKB/Swiss-Prot

A3KN99, B5MEV3
XM_039079554.2 → XP_038935482.1 solute carrier family 52, riboflavin transporter, member 2 isoform X2

UniProtKB/Swiss-Prot

A3KN99, B5MEV3

Conserved Domains (1) summary

pfam06237
Location:278 → 375

DUF1011; Protein of unknown function (DUF1011)
XM_006241826.5 → XP_006241888.1 solute carrier family 52, riboflavin transporter, member 2 isoform X2

See identical proteins and their annotated locations for XP_006241888.1

UniProtKB/Swiss-Prot

A3KN99, B5MEV3

Related

ENSRNOP00000046721.3

Conserved Domains (1) summary

pfam06237
Location:278 → 375

DUF1011; Protein of unknown function (DUF1011)
XM_063263874.1 → XP_063119944.1 solute carrier family 52, riboflavin transporter, member 2 isoform X1