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    Atp8b2 ATPase phospholipid transporting 8B2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685152, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Atp8b2provided by RGD
    Official Full Name
    ATPase phospholipid transporting 8B2provided by RGD
    Primary source
    RGD:1597731
    See related
    Ensembl:ENSRNOG00000020822 AllianceGenome:RGD:1597731
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylcholine flippase activity. Predicted to be involved in Golgi organization and phospholipid translocation. Predicted to be located in Golgi apparatus. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane and trans-Golgi network. Orthologous to human ATP8B2 (ATPase phospholipid transporting 8B2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 141.4), Thymus (RPKM 106.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q34
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (177676205..177699575, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (175378514..175402265, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (189285961..189306947, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene Src homology 2 domain containing E Neighboring gene interleukin 6 receptor Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC134485640 Neighboring gene aquaporin 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases. van der Velden LM, et al. J Biol Chem, 2010 Dec 17. PMID 20947505, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylcholine flippase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of phospholipid-translocating ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid-transporting ATPase ID
    Names
    ATPase, aminophospholipid transporter, class I, type 8B, member 2
    ATPase, class I, type 8B, member 2
    Probable phospholipid-transporting ATPase ID-like
    NP_001403541.1
    XP_001062555.3
    XP_038959701.2
    XP_038959702.1
    XP_038959706.1
    XP_063138614.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416612.1 → NP_001403541.1  phospholipid-transporting ATPase ID

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      D4A509
      Related
      ENSRNOP00000028246.5, ENSRNOT00000028246.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      177676205..177699575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103773.2 → XP_038959701.2  phospholipid-transporting ATPase ID isoform X2

      UniProtKB/TrEMBL
      D4A509

    2. XM_063282544.1 → XP_063138614.1  phospholipid-transporting ATPase ID isoform X2

      UniProtKB/TrEMBL
      D4A509

    3. XM_039103778.2 → XP_038959706.1  phospholipid-transporting ATPase ID isoform X2

      UniProtKB/TrEMBL
      A6J6I1, D4A509
      Conserved Domains (1) summary
      cd02073
      Location:31 → 972
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    4. XM_039103774.2 → XP_038959702.1  phospholipid-transporting ATPase ID isoform X1

      UniProtKB/TrEMBL
      A0A8I6GJC6, A6J6I1
      Related
      ENSRNOP00000091087.1
      Conserved Domains (1) summary
      cd02073
      Location:50 → 991
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    5. XM_001062555.7 → XP_001062555.3  phospholipid-transporting ATPase ID isoform X1

      See identical proteins and their annotated locations for XP_001062555.3

      UniProtKB/TrEMBL
      A0A8I6GJC6, A6J6I1
      Conserved Domains (1) summary
      cd02073
      Location:50 → 991
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    Nucleotide Protein Strain
    Heading Accession and Version

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