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    RPL6 ribosomal protein L6 [ Homo sapiens (human) ]

    Gene ID: 6128, updated on 7-Apr-2024

    Summary

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    Official Symbol
    RPL6provided by HGNC
    Official Full Name
    ribosomal protein L6provided by HGNC
    Primary source
    HGNC:HGNC:10362
    See related
    Ensembl:ENSG00000089009 MIM:603703; AllianceGenome:HGNC:10362
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L6; eL6; TXREB1; SHUJUN-2; TAXREB107
    Summary
    This gene encodes a protein component of the 60S ribosomal subunit. This protein can bind specifically to domain C of the tax-responsive enhancer element of human T-cell leukemia virus type 1, and may participate in tax-mediated transactivation of transcription. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
    Expression
    Ubiquitous expression in ovary (RPKM 360.8), lymph node (RPKM 224.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    12q24.13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (112405181..112418835, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (112382081..112395752, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (112842985..112856639, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene HECT domain E3 ubiquitin protein ligase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7048 Neighboring gene ribosomal protein L7a pseudogene 60 Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 2 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:112818193-112818693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4883 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:112819879-112820378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7049 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:112855308-112855956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:112855957-112856604 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:112856605-112857252 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:112876497-112876700 Neighboring gene protein tyrosine phosphatase non-receptor type 11 Neighboring gene uncharacterized LOC124903023 Neighboring gene uncharacterized LOC124903024

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. 60S ribosomal proteins L6 (RPL6) and RPL28, which are adjacent on the ribosome, play opposite roles in generating an influenza A virus-encoded peptide. Depleting RPL6 decreases ubiquitin-dependent peptide presentation, whereas depleting RPL28 increases ubiquitin-dependent and -independent peptide presentation.
      Title: Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance.
    2. The ribosomal protein L6 binds to and suppresses the E3 ubiquitin ligase activity of HDM2, and subsequently attenuates HDM2-mediated p53 polyubiquitination and degradation.
      Title: Regulation of the HDM2-p53 pathway by ribosomal protein L6 in response to ribosomal stress.
    3. Down-regulation of RPL6 could suppress cell growth and cell cycle progression at least through down-regulating cyclin E
      Title: Downregulation of RPL6 by siRNA inhibits proliferation and cell cycle progression of human gastric cancer cell lines.
    4. RPL6 was overexpressed in human gastric cancer and its over-expression could promote cell growth and cell cycle progression at least through upregulating cyclin E expression.
      Title: Ribosomal protein L6 promotes growth and cell cycle progression through upregulating cyclin E in gastric cancer cells.
    5. The high expression of RPL6/Taxreb107 in drug resistant gastric cancer cell shows its correlation with multiple-drug resistance in gastric cancer.
      Title: [Differential expression of RPL6/Taxreb107 in drug resistant gastric cancer cell line SGC7901/ADR and its correlation with multiple-drug resistance].
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L6 (RPL6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L6 (RPL6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L6 (RPL6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L6 (RPL6), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Rev rev HIV-1 Rev interacting protein, ribosomal protein L6 (RPL6), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human 60S ribosomal protein L6 (RPL6) at amino acid residues 88-89 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadherin binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in ribosomal large subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic large ribosomal subunit HDA PubMed 
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in focal adhesion HDA PubMed 
    located_in membrane HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in rough endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein eL6
    Names
    60S ribosomal protein L6
    DNA-binding protein TAXREB107
    neoplasm-related protein C140
    tax-responsive enhancer element-binding protein 107

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000970.6 → NP_000961.2  large ribosomal subunit protein eL6 isoform 1

      See identical proteins and their annotated locations for NP_000961.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is the predominant variant. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same isoform (1).
      Source sequence(s)
      AI583261, BC004138
      Consensus CDS
      CCDS9162.1
      UniProtKB/Swiss-Prot
      Q02878, Q2M3Q3, Q8WW97
      UniProtKB/TrEMBL
      B2R4K7
      Related
      ENSP00000202773.9, ENST00000202773.14
      Conserved Domains (2) summary
      cd13156
      Location:136 → 288
      KOW_RPL6; KOW motif of Ribosomal Protein L6
      pfam03868
      Location:36 → 95
      Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

    2. NM_001024662.3 → NP_001019833.1  large ribosomal subunit protein eL6 isoform 1

      See identical proteins and their annotated locations for NP_001019833.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same isoform (1).
      Source sequence(s)
      AI583261, BC004138, BC022444, BP285025
      Consensus CDS
      CCDS9162.1
      UniProtKB/Swiss-Prot
      Q02878, Q2M3Q3, Q8WW97
      UniProtKB/TrEMBL
      B2R4K7
      Related
      ENSP00000403172.2, ENST00000424576.6
      Conserved Domains (2) summary
      cd13156
      Location:136 → 288
      KOW_RPL6; KOW motif of Ribosomal Protein L6
      pfam03868
      Location:36 → 95
      Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

    3. NM_001320137.2 → NP_001307066.1  large ribosomal subunit protein eL6 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same isoform (1).
      Source sequence(s)
      AI583261, BC004138, BP285025, CB140996, CD049618
      Consensus CDS
      CCDS9162.1
      UniProtKB/Swiss-Prot
      Q02878, Q2M3Q3, Q8WW97
      UniProtKB/TrEMBL
      B2R4K7
      Conserved Domains (2) summary
      cd13156
      Location:136 → 288
      KOW_RPL6; KOW motif of Ribosomal Protein L6
      pfam03868
      Location:36 → 95
      Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

    4. NM_001320138.2 → NP_001307067.1  large ribosomal subunit protein eL6 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same isoform (1).
      Source sequence(s)
      AI583261, BC004138, BP308263
      Consensus CDS
      CCDS9162.1
      UniProtKB/Swiss-Prot
      Q02878, Q2M3Q3, Q8WW97
      UniProtKB/TrEMBL
      B2R4K7
      Conserved Domains (2) summary
      cd13156
      Location:136 → 288
      KOW_RPL6; KOW motif of Ribosomal Protein L6
      pfam03868
      Location:36 → 95
      Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

    5. NM_001320139.2 → NP_001307068.1  large ribosomal subunit protein eL6 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same isoform (1).
      Source sequence(s)
      AI583261, BC004138, CD688935, HY016219
      Consensus CDS
      CCDS9162.1
      UniProtKB/Swiss-Prot
      Q02878, Q2M3Q3, Q8WW97
      UniProtKB/TrEMBL
      B2R4K7
      Conserved Domains (2) summary
      cd13156
      Location:136 → 288
      KOW_RPL6; KOW motif of Ribosomal Protein L6
      pfam03868
      Location:36 → 95
      Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

    6. NM_001320140.2 → NP_001307069.1  large ribosomal subunit protein eL6 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same isoform (1).
      Source sequence(s)
      AI583261, BC004138, CD640506, CD688935
      Consensus CDS
      CCDS9162.1
      UniProtKB/Swiss-Prot
      Q02878, Q2M3Q3, Q8WW97
      UniProtKB/TrEMBL
      B2R4K7
      Conserved Domains (2) summary
      cd13156
      Location:136 → 288
      KOW_RPL6; KOW motif of Ribosomal Protein L6
      pfam03868
      Location:36 → 95
      Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

    7. NM_001320141.2 → NP_001307070.1  large ribosomal subunit protein eL6 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks an exon and contains three alternate exons in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same isoform (1).
      Source sequence(s)
      AI583261, BC004138, BG722198
      Consensus CDS
      CCDS9162.1
      UniProtKB/Swiss-Prot
      Q02878, Q2M3Q3, Q8WW97
      UniProtKB/TrEMBL
      B2R4K7
      Conserved Domains (2) summary
      cd13156
      Location:136 → 288
      KOW_RPL6; KOW motif of Ribosomal Protein L6
      pfam03868
      Location:36 → 95
      Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

    8. NM_001320142.1 → NP_001307071.1  large ribosomal subunit protein eL6 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AI583261, BG030827, HY038019
      Conserved Domains (1) summary
      cd13156
      Location:25 → 177
      KOW_RPL6; KOW motif of Ribosomal Protein L6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      112405181..112418835 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429303.1 → XP_047285259.1  large ribosomal subunit protein eL6 isoform X1

      UniProtKB/Swiss-Prot
      Q02878, Q2M3Q3, Q8WW97

    2. XM_047429304.1 → XP_047285260.1  large ribosomal subunit protein eL6 isoform X2

    3. XM_047429302.1 → XP_047285258.1  large ribosomal subunit protein eL6 isoform X1

      UniProtKB/Swiss-Prot
      Q02878, Q2M3Q3, Q8WW97

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      112382081..112395752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372828.1 → XP_054228803.1  large ribosomal subunit protein eL6 isoform X1

      UniProtKB/Swiss-Prot
      Q02878, Q2M3Q3, Q8WW97

    2. XM_054372830.1 → XP_054228805.1  large ribosomal subunit protein eL6 isoform X1

      UniProtKB/Swiss-Prot
      Q02878, Q2M3Q3, Q8WW97

    3. XM_054372831.1 → XP_054228806.1  large ribosomal subunit protein eL6 isoform X2

    4. XM_054372829.1 → XP_054228804.1  large ribosomal subunit protein eL6 isoform X1

      UniProtKB/Swiss-Prot
      Q02878, Q2M3Q3, Q8WW97
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02878.3 GenPept UniProtKB/Swiss-Prot:Q02878

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