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    Churc1 churchill domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299154, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Churc1provided by RGD
    Official Full Name
    churchill domain containing 1provided by RGD
    Primary source
    RGD:1305116
    See related
    Ensembl:ENSRNOG00000007660 AllianceGenome:RGD:1305116
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. Orthologous to human CHURC1 (churchill domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 469.6), Heart (RPKM 421.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Churc1 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (101203778..101218364)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (95464488..95485208)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (99817439..99831574)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene spectrin, beta, erythrocytic Neighboring gene uncharacterized LOC134479402 Neighboring gene U6 spliceosomal RNA Neighboring gene glutathione peroxidase 2 Neighboring gene RAB15, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Churchill, a zinc finger transcriptional activator, regulates the transition between gastrulation and neurulation. Sheng G, et al. Cell, 2003 Nov 26. PMID 14651851
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein farnesyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in prenylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of microtubule associated complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein farnesyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein Churchill

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106741.2 → NP_001100211.1  protein Churchill

      See identical proteins and their annotated locations for NP_001100211.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168770
      UniProtKB/TrEMBL
      A0A8I5ZP53, B5DER2, F7FBS9
      Related
      ENSRNOP00000009620.5, ENSRNOT00000009621.7
      Conserved Domains (1) summary
      pfam06573
      Location:1 → 111
      Churchill; Churchill protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      101203778..101218364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112015.2 → XP_038967943.1  protein Churchill isoform X1

      UniProtKB/TrEMBL
      A0A8I6GKJ2
      Related
      ENSRNOP00000094000.1
      Conserved Domains (1) summary
      pfam06573
      Location:1 → 60
      Churchill; Churchill protein
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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