BIRC3 baculoviral IAP repeat containing 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: BIRC3provided by HGNC
Official Full Name: baculoviral IAP repeat containing 3provided by HGNC
Primary source: HGNC:HGNC:591
See related: Ensembl:ENSG00000023445 MIM:601721; AllianceGenome:HGNC:591
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AIP1; API2; MIHC; CIAP2; HAIP1; HIAP1; IAP-1; MALT2; RNF49; c-IAP2
Summary: This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]
Expression: Broad expression in lymph node (RPKM 48.6), appendix (RPKM 43.1) and 15 other tissues See more
Orthologs: all
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Genomic context

Location:: 11q22.2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (102317484..102339403)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (102319603..102341520)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (102188215..102210134)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CircNUP54 promotes hepatocellular carcinoma progression via facilitating HuR cytoplasmic export and stabilizing BIRC3 mRNA.
Title: CircNUP54 promotes hepatocellular carcinoma progression via facilitating HuR cytoplasmic export and stabilizing BIRC3 mRNA.
Identification and validation of prognostic and tumor microenvironment characteristics of necroptosis index and BIRC3 in clear cell renal cell carcinoma.
Title: Identification and validation of prognostic and tumor microenvironment characteristics of necroptosis index and BIRC3 in clear cell renal cell carcinoma.
Identification of mutation gene prognostic biomarker in multiple myeloma through gene panel exome sequencing and transcriptome analysis in Chinese population.
Title: Identification of mutation gene prognostic biomarker in multiple myeloma through gene panel exome sequencing and transcriptome analysis in Chinese population.
SNHG1, a KLF4-upregulated gene, promotes glioma cell survival and tumorigenesis under endoplasmic reticulum stress by upregulating BIRC3 expression.
Title: SNHG1, a KLF4-upregulated gene, promotes glioma cell survival and tumorigenesis under endoplasmic reticulum stress by upregulating BIRC3 expression.
[The correlation of CD49d expression pattern with molecular genetics and hotspot gene mutants in patients with chronic lymphocytic leukemia].
Title: [The correlation of CD49d expression pattern with molecular genetics and hotspot gene mutants in patients with chronic lymphocytic leukemia].
Prognostic Significance of the BIRC2-BIRC3 Gene Signature in Head and Neck Squamous Cell Carcinoma.
Title: Prognostic Significance of the BIRC2-BIRC3 Gene Signature in Head and Neck Squamous Cell Carcinoma.
Multiomics analysis identifies BIRC3 as a novel glucocorticoid response-associated gene.
Title: Multiomics analysis identifies BIRC3 as a novel glucocorticoid response-associated gene.
Exploration of induced sputum BIRC3 levels and clinical implications in asthma.
Title: Exploration of induced sputum BIRC3 levels and clinical implications in asthma.
Proteomic analysis of inhibitor of apoptosis proteinlike protein2 on breast cancer cell proliferation.
Title: Proteomic analysis of inhibitor of apoptosis protein‑like protein‑2 on breast cancer cell proliferation.
BIRC2-BIRC3 amplification: a potentially druggable feature of a subset of head and neck cancers in patients with Fanconi anemia.
Title: BIRC2-BIRC3 amplification: a potentially druggable feature of a subset of head and neck cancers in patients with Fanconi anemia.

Submit: New GeneRIF Correction See all GeneRIFs (173)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120-treated vaginal epithelial cells show upregulation of baculoviral IAP repeat containing 3 (BIRC3) expression as compared to untreated control	PubMed
Tat	tat	HIV-1 Tat101 upregulates the expression of baculoviral IAP repeat-containing 3 (BIRC3; C-IAP2) in Jurkat cells	PubMed
	tat	Microarray analysis indicates HIV-1 Tat upregulates the expression of many proteins, including MIHC, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection	PubMed
Vpr	vpr	HIV-1 Vpr [TRAF1 and TRAF2 downregulation] is counteracted by BIRC3 (c-IAP-2) in THP-1 cells and monocytes	PubMed
	vpr	Anti-apoptotic proteins BIRC3 (cIAP1) and cIAP2 contribute to macrophage protection against HIV-1 Vpr-induced apoptosis	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G60088 (e-PCR)
- UniSTS:137217

PMC229255P1 (e-PCR)
- UniSTS:272168

RH79205 (e-PCR)
- UniSTS:39572

SHGC-31347 (e-PCR)
- UniSTS:22678

SGC33804 (e-PCR)
- UniSTS:68768

G43312 (e-PCR)
- UniSTS:94933

PMC166414P2 (e-PCR)
- UniSTS:271591

A007H38 (e-PCR)
- UniSTS:56564

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	EXP Inferred from Experiment more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	EXP Inferred from Experiment more info	PubMed
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in canonical NF-kappaB signal transduction	TAS Traceable Author Statement more info
involved_in cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of necroptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-canonical NF-kappaB signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of RIG-I signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cysteine-type endopeptidase activity	TAS Traceable Author Statement more info	PubMed
involved_in regulation of inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in regulation of innate immune response	TAS Traceable Author Statement more info	PubMed
involved_in regulation of necroptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of necroptotic process	TAS Traceable Author Statement more info
involved_in regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in regulation of toll-like receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in tumor necrosis factor-mediated signaling pathway	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: baculoviral IAP repeat-containing protein 3

Names: IAP homolog C; RING finger protein 49; RING-type E3 ubiquitin transferase BIRC3; TNFR2-TRAF signaling complex protein; TNFR2-TRAF-signaling complex protein 1; apoptosis inhibitor 2; cellular inhibitor of apoptosis 2; inhibitor of apoptosis protein 1; mammalian IAP homolog C

NP_001156.1

EC 2.3.2.27

NP_892007.1

EC 2.3.2.27

XP_054224588.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_065365.1 RefSeqGene

Range

5001..26920

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1423

mRNA and Protein(s)

NM_001165.5 → NP_001156.1 baculoviral IAP repeat-containing protein 3

See identical proteins and their annotated locations for NP_001156.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AA805622, AA873008, AF070674, AI880555, BC037420, BE907592, BG569841, BU428906, BX415415, BX475964, U37546, U45878

Consensus CDS

CCDS8315.1

UniProtKB/Swiss-Prot

Q13489, Q16628, Q9HC27, Q9UP46

UniProtKB/TrEMBL

A0A669KBC7

Related

ENSP00000263464.4, ENST00000263464.9

Conserved Domains (4) summary

smart00238
Location:254 → 322

BIR; Baculoviral inhibition of apoptosis protein repeat

cd08329
Location:441 → 530

CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)

pfam13920
Location:553 → 598

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

cl21463
Location:377 → 411

UBA_like_SF; UBA domain-like superfamily
NM_182962.3 → NP_892007.1 baculoviral IAP repeat-containing protein 3

See identical proteins and their annotated locations for NP_892007.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AA805622, AA873008, AI880555, BC037420, BE907592, BG569841, BX415415, L49432, U45878

Consensus CDS

CCDS8315.1

UniProtKB/Swiss-Prot

Q13489, Q16628, Q9HC27, Q9UP46

UniProtKB/TrEMBL

A0A669KBC7

Related

ENSP00000432907.1, ENST00000532808.5

Conserved Domains (4) summary

smart00238
Location:254 → 322

BIR; Baculoviral inhibition of apoptosis protein repeat

cd08329
Location:441 → 530

CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)

pfam13920
Location:553 → 598

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

cl21463
Location:377 → 411

UBA_like_SF; UBA domain-like superfamily