NLRC5 NLR family CARD domain containing 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NLRC5provided by HGNC
Official Full Name: NLR family CARD domain containing 5provided by HGNC
Primary source: HGNC:HGNC:29933
See related: Ensembl:ENSG00000140853 MIM:613537; AllianceGenome:HGNC:29933
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NOD4; NOD27; CLR16.1
Summary: This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011]
Expression: Broad expression in spleen (RPKM 23.6), lymph node (RPKM 20.1) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16q13

Exon count:: 55

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (56989557..57083520)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (62785869..62879790)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (57023469..57117432)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rescue of NLRC5 expression restores antigen processing machinery in head and neck cancer cells lacking functional STAT1 and p53.
Title: Rescue of NLRC5 expression restores antigen processing machinery in head and neck cancer cells lacking functional STAT1 and p53.
NLRC5 overexpression in ovarian tumors remodels the tumor microenvironment and increases T-cell reactivity toward autologous tumor-associated antigens.
Title: NLRC5 overexpression in ovarian tumors remodels the tumor microenvironment and increases T-cell reactivity toward autologous tumor-associated antigens.
USP14-mediated NLRC5 upregulation inhibits endothelial cell activation and inflammation in atherosclerosis.
Title: USP14-mediated NLRC5 upregulation inhibits endothelial cell activation and inflammation in atherosclerosis.
NLRC5 germline variants as potential pharmacogenomic markers for immune checkpoint inhibitors.
Title: NLRC5 germline variants as potential pharmacogenomic markers for immune checkpoint inhibitors.
NLRC5-CIITA Fusion Protein as an Effective Inducer of MHC-I Expression and Antitumor Immunity.
Title: NLRC5-CIITA Fusion Protein as an Effective Inducer of MHC-I Expression and Antitumor Immunity.
NLRC5 restricts dengue virus infection by promoting the autophagic degradation of viral NS3 through E3 ligase CUL2 (cullin 2).
Title: NLRC5 restricts dengue virus infection by promoting the autophagic degradation of viral NS3 through E3 ligase CUL2 (cullin 2).
NLR family CARD domain containing 5 promotes hypoxia-induced cancer progress and carboplatin resistance by activating PI3K/AKT via carcinoembryonic antigen related cell adhesion molecule 1 in non-small cell lung cancer.
Title: NLR family CARD domain containing 5 promotes hypoxia-induced cancer progress and carboplatin resistance by activating PI3K/AKT via carcinoembryonic antigen related cell adhesion molecule 1 in non-small cell lung cancer.
BMI1 induces ubiquitination and protein degradation of Nod-like receptor family CARD domain containing 5 and suppresses human leukocyte antigen class I expression to induce immune escape in non-small cell lung cancer.
Title: BMI1 induces ubiquitination and protein degradation of Nod-like receptor family CARD domain containing 5 and suppresses human leukocyte antigen class I expression to induce immune escape in non-small cell lung cancer.
Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic beta cells.
Title: Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic β cells.
NLRC5 modulates phenotypic transition and inflammation of human venous smooth muscle cells by activating Wnt/beta-catenin pathway via TLR4 in varicose veins.
Title: NLRC5 modulates phenotypic transition and inflammation of human venous smooth muscle cells by activating Wnt/β-catenin pathway via TLR4 in varicose veins.

Submit: New GeneRIF Correction See all GeneRIFs (68)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of NLR family, CARD domain containing 5 (NLRC5) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-60981 (e-PCR)
- UniSTS:21081

D16S3209 (e-PCR)
- UniSTS:21082

RH65291 (e-PCR)
- UniSTS:92066

D16S2726 (e-PCR)
- UniSTS:153296

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to virus	IEP Inferred from Expression Pattern more info	PubMed
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of type I interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of type I interferon-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MHC class I biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MHC class I biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of type I interferon-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of type II interferon-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of type II interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in response to bacterium	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein NLRC5

Names: NOD-like receptor C5; caterpiller protein 16.1; nucleotide-binding oligomerization domain protein 4; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5; nucleotide-binding oligomerization domains 27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_030337.3 RefSeqGene

Range

5073..99036

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001330552.2 → NP_001317481.1 protein NLRC5 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 and 4 both encode the same isoform (2).

Source sequence(s)

AA722775, AC009090, AC023825

Consensus CDS

CCDS81985.1

UniProtKB/Swiss-Prot

Q86WI3

Related

ENSP00000441727.1, ENST00000539144.5

Conserved Domains (6) summary

sd00033
Location:1495 → 1516

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:1436 → 1466

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:222 → 383

NACHT; NACHT domain

pfam17776
Location:514 → 628

NLRC4_HD2; NLRC4 helical domain HD2

pfam18461
Location:1 → 95

Atypical_Card; Atypical caspase recruitment domain

cl39015
Location:1493 → 1793

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001384950.1 → NP_001371879.1 protein NLRC5 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (3), as well as variant 1, encodes isoform 1.

Source sequence(s)

AC009090, AC023825

Consensus CDS

CCDS10773.1

UniProtKB/Swiss-Prot

B5MEF1, C9JMD8, Q6P4A6, Q86VM7, Q86WI3, Q8NF42, Q8TEE2, Q8TEJ1, Q969L7

Related

ENSP00000509992.1, ENST00000688547.1

Conserved Domains (6) summary

sd00033
Location:1524 → 1545

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:1465 → 1495

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:222 → 383

NACHT; NACHT domain

pfam17776
Location:514 → 628

NLRC4_HD2; NLRC4 helical domain HD2

pfam18461
Location:1 → 95

Atypical_Card; Atypical caspase recruitment domain

cl39015
Location:1522 → 1822

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001384951.1 → NP_001371880.1 protein NLRC5 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (4), as well as variant 2, encodes isoform 2.

Source sequence(s)

AC009090, AC023825

Consensus CDS

CCDS81985.1

Conserved Domains (6) summary

sd00033
Location:1495 → 1516

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:1436 → 1466

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:222 → 383

NACHT; NACHT domain

pfam17776
Location:514 → 628

NLRC4_HD2; NLRC4 helical domain HD2

pfam18461
Location:1 → 95

Atypical_Card; Atypical caspase recruitment domain

cl39015
Location:1493 → 1793

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001384952.1 → NP_001371881.1 protein NLRC5 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (5), as well as variant 6, encodes isoform 3.

Source sequence(s)

AC009090, AC023825

Conserved Domains (6) summary

sd00033
Location:1523 → 1544

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:1464 → 1494

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:222 → 383

NACHT; NACHT domain

pfam17776
Location:514 → 628

NLRC4_HD2; NLRC4 helical domain HD2

pfam18461
Location:1 → 95

Atypical_Card; Atypical caspase recruitment domain

cl39015
Location:1521 → 1821

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001384953.1 → NP_001371882.1 protein NLRC5 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (6), as well as variant 5, encodes isoform 3.

Source sequence(s)

AC009090, AC023825

Conserved Domains (6) summary

sd00033
Location:1523 → 1544

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:1464 → 1494

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:222 → 383

NACHT; NACHT domain

pfam17776
Location:514 → 628

NLRC4_HD2; NLRC4 helical domain HD2

pfam18461
Location:1 → 95

Atypical_Card; Atypical caspase recruitment domain

cl39015
Location:1521 → 1821

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001384954.1 → NP_001371883.1 protein NLRC5 isoform 4

Status: REVIEWED

Source sequence(s)

AC009090, AC023825

Conserved Domains (6) summary

sd00033
Location:1496 → 1517

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:1437 → 1467

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:222 → 383

NACHT; NACHT domain

pfam17776
Location:514 → 628

NLRC4_HD2; NLRC4 helical domain HD2

pfam18461
Location:1 → 95

Atypical_Card; Atypical caspase recruitment domain

cl39015
Location:1494 → 1794

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001384955.1 → NP_001371884.1 protein NLRC5 isoform 5

Status: REVIEWED

Source sequence(s)

AC009090, AC023825

Conserved Domains (6) summary

sd00033
Location:1495 → 1516

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:1436 → 1466

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:222 → 383

NACHT; NACHT domain

pfam17776
Location:514 → 628

NLRC4_HD2; NLRC4 helical domain HD2

pfam18461
Location:1 → 95

Atypical_Card; Atypical caspase recruitment domain

cl39015
Location:1493 → 1793

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001384956.1 → NP_001371885.1 protein NLRC5 isoform 6

Status: REVIEWED

Source sequence(s)

AC009090, AC023825

Conserved Domains (6) summary

sd00033
Location:1495 → 1516

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:1436 → 1466

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:222 → 383

NACHT; NACHT domain

pfam17776
Location:514 → 628

NLRC4_HD2; NLRC4 helical domain HD2

pfam18461
Location:1 → 95

Atypical_Card; Atypical caspase recruitment domain

cl39015
Location:1493 → 1793

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001384957.1 → NP_001371886.1 protein NLRC5 isoform 7

Status: REVIEWED

Source sequence(s)

AC009090, AC023825

Conserved Domains (6) summary

sd00033
Location:1494 → 1515

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:1435 → 1465

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:222 → 383

NACHT; NACHT domain

pfam17776
Location:514 → 628

NLRC4_HD2; NLRC4 helical domain HD2

pfam18461
Location:1 → 95

Atypical_Card; Atypical caspase recruitment domain

cl39015
Location:1492 → 1792

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001384958.1 → NP_001371887.1 protein NLRC5 isoform 8

Status: REVIEWED

Source sequence(s)

AC009090, AC023825

Conserved Domains (7) summary

sd00033
Location:1466 → 1487

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:1407 → 1437

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:222 → 383

NACHT; NACHT domain

pfam17776
Location:514 → 628

NLRC4_HD2; NLRC4 helical domain HD2

pfam18461
Location:1 → 95

Atypical_Card; Atypical caspase recruitment domain

cd21340
Location:705 → 783

PPP1R42; protein phosphatase 1 regulatory subunit 42

cl39015
Location:1464 → 1764

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001384959.1 → NP_001371888.1 protein NLRC5 isoform 9

Status: REVIEWED

Source sequence(s)

AC009090, AC023825

Conserved Domains (7) summary

sd00033
Location:1465 → 1486

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:1406 → 1436

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:222 → 383

NACHT; NACHT domain

pfam17776
Location:514 → 628

NLRC4_HD2; NLRC4 helical domain HD2

pfam18461
Location:1 → 95

Atypical_Card; Atypical caspase recruitment domain

cd21340
Location:705 → 783

PPP1R42; protein phosphatase 1 regulatory subunit 42

cl39015
Location:1463 → 1763

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001384960.1 → NP_001371889.1 protein NLRC5 isoform 10

Status: REVIEWED

Source sequence(s)

AC009090, AC023825

Conserved Domains (6) summary

sd00033
Location:1493 → 1520

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:1383 → 1405

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:222 → 383

NACHT; NACHT domain

pfam17776
Location:514 → 628

NLRC4_HD2; NLRC4 helical domain HD2

pfam18461
Location:1 → 95

Atypical_Card; Atypical caspase recruitment domain

cl39015
Location:1447 → 1735

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001384961.1 → NP_001371890.1 protein NLRC5 isoform 11

Status: REVIEWED

Description

Transcript Variant: This variant (14), as well as variant 15, encodes isoform 11.

Source sequence(s)

AC023825

UniProtKB/TrEMBL

H0YGE2

Conserved Domains (5) summary

sd00033
Location:716 → 743

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:222 → 383

NACHT; NACHT domain

pfam17776
Location:514 → 628

NLRC4_HD2; NLRC4 helical domain HD2

pfam18461
Location:1 → 95

Atypical_Card; Atypical caspase recruitment domain

cl39015
Location:690 → 1069

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001384962.1 → NP_001371891.1 protein NLRC5 isoform 11

Status: REVIEWED

Description

Transcript Variant: This variant (15), as well as variant 14, encodes isoform 11.

Source sequence(s)

AC023825

UniProtKB/TrEMBL

H0YGE2

Conserved Domains (5) summary

sd00033
Location:716 → 743

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:222 → 383

NACHT; NACHT domain

pfam17776
Location:514 → 628

NLRC4_HD2; NLRC4 helical domain HD2

pfam18461
Location:1 → 95

Atypical_Card; Atypical caspase recruitment domain

cl39015
Location:690 → 1069

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001384963.1 → NP_001371892.1 protein NLRC5 isoform 12

Status: REVIEWED

Description

Transcript Variant: This variant (16), as well as variant 17, encodes isoform 12.

Source sequence(s)

AC023825

UniProtKB/TrEMBL

H0YGE2

Conserved Domains (5) summary

sd00033
Location:716 → 743

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:222 → 383

NACHT; NACHT domain

pfam17776
Location:514 → 628

NLRC4_HD2; NLRC4 helical domain HD2

pfam18461
Location:1 → 95

Atypical_Card; Atypical caspase recruitment domain

cl39015
Location:690 → 1069

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001384964.1 → NP_001371893.1 protein NLRC5 isoform 12

Status: REVIEWED

Description

Transcript Variant: This variant (17), as well as variant 16, encodes isoform 12.

Source sequence(s)

AC023825

UniProtKB/TrEMBL

H0YGE2

Conserved Domains (5) summary

sd00033
Location:716 → 743

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:222 → 383

NACHT; NACHT domain

pfam17776
Location:514 → 628

NLRC4_HD2; NLRC4 helical domain HD2

pfam18461
Location:1 → 95

Atypical_Card; Atypical caspase recruitment domain

cl39015
Location:690 → 1069

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001384965.1 → NP_001371894.1 protein NLRC5 isoform 13

Status: REVIEWED

Source sequence(s)

AC023825

UniProtKB/TrEMBL

H0YGE2

Conserved Domains (5) summary

sd00033
Location:688 → 715

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:222 → 383

NACHT; NACHT domain

pfam17776
Location:514 → 628

NLRC4_HD2; NLRC4 helical domain HD2

pfam18461
Location:1 → 95

Atypical_Card; Atypical caspase recruitment domain

cl39015
Location:819 → 1040

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001384966.1 → NP_001371895.1 protein NLRC5 isoform 14

Status: REVIEWED

Source sequence(s)

AC023825

UniProtKB/TrEMBL

H0YGE2

Conserved Domains (5) summary

sd00033
Location:716 → 743

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:222 → 383

NACHT; NACHT domain

pfam17776
Location:514 → 628

NLRC4_HD2; NLRC4 helical domain HD2

pfam18461
Location:1 → 95

Atypical_Card; Atypical caspase recruitment domain

cl39015
Location:690 → 1069

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001384967.1 → NP_001371896.1 protein NLRC5 isoform 15

Status: REVIEWED

Source sequence(s)

AC023825

UniProtKB/TrEMBL

H0YGE2

Conserved Domains (5) summary

sd00033
Location:716 → 743

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:222 → 383

NACHT; NACHT domain

pfam17776
Location:514 → 628

NLRC4_HD2; NLRC4 helical domain HD2

pfam18461
Location:1 → 95

Atypical_Card; Atypical caspase recruitment domain

cl39015
Location:690 → 1069

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001384968.1 → NP_001371897.1 protein NLRC5 isoform 16

Status: REVIEWED

Source sequence(s)

AC023825

UniProtKB/TrEMBL

H0YGE2

Conserved Domains (5) summary

sd00033
Location:716 → 743

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:222 → 383

NACHT; NACHT domain

pfam17776
Location:514 → 628

NLRC4_HD2; NLRC4 helical domain HD2

pfam18461
Location:1 → 95

Atypical_Card; Atypical caspase recruitment domain

cl39015
Location:690 → 1069

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001384969.1 → NP_001371898.1 protein NLRC5 isoform 17

Status: REVIEWED

Source sequence(s)

AC023825

UniProtKB/TrEMBL

H0YGE2

Conserved Domains (5) summary

sd00033
Location:716 → 743

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:222 → 383

NACHT; NACHT domain

pfam17776
Location:514 → 628

NLRC4_HD2; NLRC4 helical domain HD2

pfam18461
Location:1 → 95

Atypical_Card; Atypical caspase recruitment domain

cl39015
Location:690 → 1069

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001384970.1 → NP_001371899.1 protein NLRC5 isoform 18

Status: REVIEWED

Source sequence(s)

AC023825

UniProtKB/TrEMBL

H0YGE2

Conserved Domains (5) summary

sd00033
Location:716 → 743

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:222 → 383

NACHT; NACHT domain

pfam17776
Location:514 → 628

NLRC4_HD2; NLRC4 helical domain HD2

pfam18461
Location:1 → 95

Atypical_Card; Atypical caspase recruitment domain

cl39015
Location:690 → 1069

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001384971.1 → NP_001371900.1 protein NLRC5 isoform 19

Status: REVIEWED

Source sequence(s)

AC023825

UniProtKB/TrEMBL

H0YGE2

Conserved Domains (5) summary

sd00033
Location:716 → 743

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:222 → 383

NACHT; NACHT domain

pfam17776
Location:514 → 628

NLRC4_HD2; NLRC4 helical domain HD2

pfam18461
Location:1 → 95

Atypical_Card; Atypical caspase recruitment domain

cl39015
Location:690 → 1069

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001384972.1 → NP_001371901.1 protein NLRC5 isoform 20

Status: REVIEWED

Source sequence(s)

AC023825

UniProtKB/TrEMBL

H0YGE2

Conserved Domains (5) summary

sd00033
Location:659 → 686

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:205 → 326

NACHT; NACHT domain

pfam17776
Location:457 → 571

NLRC4_HD2; NLRC4 helical domain HD2

pfam18461
Location:1 → 95

Atypical_Card; Atypical caspase recruitment domain

cl39015
Location:633 → 989

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001384973.1 → NP_001371902.1 protein NLRC5 isoform 21

Status: REVIEWED

Source sequence(s)

AC023825

Conserved Domains (6) summary

sd00033
Location:716 → 743

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:222 → 383

NACHT; NACHT domain

pfam17776
Location:514 → 628

NLRC4_HD2; NLRC4 helical domain HD2

pfam18461
Location:1 → 95

Atypical_Card; Atypical caspase recruitment domain

cd21340
Location:705 → 783

PPP1R42; protein phosphatase 1 regulatory subunit 42

cl39015
Location:745 → 1069

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_032206.5 → NP_115582.4 protein NLRC5 isoform 1

See identical proteins and their annotated locations for NP_115582.4

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).

Source sequence(s)

AC009090, AC023825

Consensus CDS

CCDS10773.1

UniProtKB/Swiss-Prot

B5MEF1, C9JMD8, Q6P4A6, Q86VM7, Q86WI3, Q8NF42, Q8TEE2, Q8TEJ1, Q969L7

Related

ENSP00000262510.6, ENST00000262510.10

Conserved Domains (6) summary

sd00033
Location:1524 → 1545

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:1465 → 1495

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:222 → 383

NACHT; NACHT domain

pfam17776
Location:514 → 628

NLRC4_HD2; NLRC4 helical domain HD2

pfam18461
Location:1 → 95

Atypical_Card; Atypical caspase recruitment domain

cl39015
Location:1522 → 1822

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RNA

NR_169512.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC009090, AC023825
NR_169513.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC009090, AC023825
NR_169514.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC023825
NR_169515.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC009090, AC023825
NR_169516.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC009090, AC023825
NR_169517.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC009090, AC023825

Related

ENST00000545081.5
NR_169518.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC009090, AC023825
NR_169519.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC009090, AC023825
NR_169520.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC009090, AC023825

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

56989557..57083520

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047434762.1 → XP_047290718.1 protein NLRC5 isoform X3
XM_047434763.1 → XP_047290719.1 protein NLRC5 isoform X4
XM_047434760.1 → XP_047290716.1 protein NLRC5 isoform X1
XM_047434761.1 → XP_047290717.1 protein NLRC5 isoform X2
XM_047434764.1 → XP_047290720.1 protein NLRC5 isoform X5
XM_006721300.3 → XP_006721363.1 protein NLRC5 isoform X7

UniProtKB/TrEMBL

H0YGE2

Conserved Domains (5) summary

smart00382
Location:221 → 365

AAA; ATPases associated with a variety of cellular activities

COG4886
Location:731 → 936

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00116
Location:690 → 1069

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:716 → 743

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:222 → 383

NACHT; NACHT domain
XM_047434765.1 → XP_047290721.1 protein NLRC5 isoform X7
XM_017023770.2 → XP_016879259.1 protein NLRC5 isoform X6

UniProtKB/TrEMBL

H0YGE2

Related

ENSP00000442906.1, ENST00000538805.5
XM_047434766.1 → XP_047290722.1 protein NLRC5 isoform X8