Noxo1 NADPH oxidase organizer 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Noxo1provided by MGI
Official Full Name: NADPH oxidase organizer 1provided by MGI
Primary source: MGI:MGI:1919143
See related: Ensembl:ENSMUSG00000019320 AllianceGenome:MGI:1919143
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: hslt; Snx28; P41NOX; P41NOXA; P41NOXB; P41NOXC; 2310034C04Rik
Summary: Enables superoxide-generating NADPH oxidase activator activity. Acts upstream of or within superoxide metabolic process. Predicted to be located in plasma membrane. Predicted to be part of NADPH oxidase complex. Predicted to be active in cytoplasm. Is expressed in inner ear vestibular component; rectum; and submandibular gland primordium. Orthologous to human NOXO1 (NADPH oxidase organizer 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon adult (RPKM 35.9), large intestine adult (RPKM 30.6) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 12.49 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (24915208..24919504)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (24696234..24700530)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of NoxO1 limits atherosclerosis development in female mice.
Title: Deletion of NoxO1 limits atherosclerosis development in female mice.
ROS production stimulated by NoxO1 and p47phox limit endothelium-dependent relaxation and maintain blood pressure in mice. However, NoxO1 and p47phox cannot substitute each other despite their similar effect on vascular function. Deletion of NoxO1 induced an anti-inflammatory phenotype, whereas p47phox deletion rather elicited a hyper-inflammatory response.
Title: The NADPH organizers NoxO1 and p47phox are both mediators of diabetes-induced vascular dysfunction in mice.
NoxO1 stimulates alpha-secretase activity probably through reactive oxygen species-mediated oxidation. Deletion of NoxO1 attenuates Notch signaling and thereby promotes a tip-cell phenotype that results in increased angiogenesis.
Title: The Cytosolic NADPH Oxidase Subunit NoxO1 Promotes an Endothelial Stalk Cell Phenotype.
Genetic susceptibility to alcoholic steatohepatitis was linked to two candidate genes, Noxo1 (and Nlrc4).
Title: Genetic resistance to liver fibrosis on A/J mouse chromosome 17.
The first quantitative characterization of the interactions made between the cytosolic regulators NOXO1 and NOXA1 and membrane-bound p22(phox), is presented.
Title: Regulation of NOXO1 activity through reversible interactions with p22 and NOXA1.
role in activating superoxide generation by the NADPH oxidase NOX1
Title: Two novel proteins activate superoxide generation by the NADPH oxidase NOX1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables superoxide-generating NADPH oxidase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables superoxide-generating NADPH oxidase activator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in superoxide anion generation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within superoxide metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of NADPH oxidase complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: NADPH oxidase organizer 1

Names: nox organizer 1; sorting nexin-28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357836.1 → NP_001344765.1 NADPH oxidase organizer 1

Status: VALIDATED

Source sequence(s)

AC154566, BE948950

Consensus CDS

CCDS50018.1

UniProtKB/Swiss-Prot

Q3TZA4, Q8BH41, Q8VCM2, Q9D747

UniProtKB/TrEMBL

Q0VDT6

Conserved Domains (3) summary

cd12024
Location:235 → 287

SH3_NoxO1_2; Second or C-terminal Src homology 3 domain of NADPH oxidase (Nox) Organizing protein 1

cl02563
Location:3 → 122

PX_domain; The Phox Homology domain, a phosphoinositide binding module

cl17036
Location:161 → 216

SH3; Src Homology 3 domain superfamily
NM_027988.4 → NP_082264.2 NADPH oxidase organizer 1

See identical proteins and their annotated locations for NP_082264.2

Status: VALIDATED

Source sequence(s)

AC154566

Consensus CDS

CCDS50018.1

UniProtKB/Swiss-Prot

Q3TZA4, Q8BH41, Q8VCM2, Q9D747

UniProtKB/TrEMBL

Q0VDT6

Related

ENSMUSP00000019464.8, ENSMUST00000019464.8

Conserved Domains (3) summary

cd12024
Location:235 → 287

SH3_NoxO1_2; Second or C-terminal Src homology 3 domain of NADPH oxidase (Nox) Organizing protein 1

cl02563
Location:3 → 122

PX_domain; The Phox Homology domain, a phosphoinositide binding module

cl17036
Location:161 → 216

SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

24915208..24919504

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017317652.2 → XP_017173141.1 NADPH oxidase organizer 1 isoform X2

Conserved Domains (2) summary

cl02563
Location:3 → 122

PX_domain; The Phox Homology domain, a phosphoinositide binding module

cl17036
Location:161 → 216

SH3; Src Homology 3 domain superfamily
XM_006524951.4 → XP_006525014.1 NADPH oxidase organizer 1 isoform X1

UniProtKB/TrEMBL

Q0VDT6

Conserved Domains (3) summary

cd12024
Location:234 → 286

SH3_NoxO1_2; Second or C-terminal Src homology 3 domain of NADPH oxidase (Nox) Organizing protein 1

cl02563
Location:3 → 121

PX_domain; The Phox Homology domain, a phosphoinositide binding module

cl17036
Location:160 → 215

SH3; Src Homology 3 domain superfamily
XM_011246630.2 → XP_011244932.1 NADPH oxidase organizer 1 isoform X3

Conserved Domains (2) summary

cd12024
Location:107 → 159

SH3_NoxO1_2; Second or C-terminal Src homology 3 domain of NADPH oxidase (Nox) Organizing protein 1

cl17036
Location:33 → 88

SH3; Src Homology 3 domain superfamily