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    Txndc5 thioredoxin domain containing 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100362805, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Txndc5provided by RGD
    Official Full Name
    thioredoxin domain containing 5provided by RGD
    Primary source
    RGD:2323973
    See related
    Ensembl:ENSRNOG00000013469 AllianceGenome:RGD:2323973
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein disulfide isomerase activity. Predicted to be involved in apoptotic cell clearance. Predicted to be located in endoplasmic reticulum lumen. Orthologous to human TXNDC5 (thioredoxin domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 763.2), Spleen (RPKM 476.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    17p12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (26495467..26523608)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (26289880..26318025)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (26925828..26953981)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097825 Neighboring gene uncharacterized LOC134482844 Neighboring gene bone morphogenetic protein 6 Neighboring gene small nuclear ribonucleoprotein U11/U12 subunit 48

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins. Knoblach B, et al. Mol Cell Proteomics, 2003 Oct. PMID 12930873
    2. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
    3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    4. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
    5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein disulfide isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-disulfide reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    thioredoxin domain-containing protein 5
    Names
    thioredoxin domain containing 5 (endoplasmic reticulum)
    NP_001258259.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271330.1 → NP_001258259.1  thioredoxin domain-containing protein 5 precursor

      See identical proteins and their annotated locations for NP_001258259.1

      Status: VALIDATED

      Source sequence(s)
      FM045749, FM067602, FM093163, JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I6GKN1, A6J7A3, D3ZZC1
      Related
      ENSRNOP00000018310.5, ENSRNOT00000018310.8
      Conserved Domains (2) summary
      cd03005
      Location:176 → 276
      PDI_a_ERp46; PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in ...
      TIGR01130
      Location:52 → 417
      ER_PDI_fam; protein disulfide isomerase, eukaryotic

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      26495467..26523608
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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