Rbpms RNA binding protein, mRNA processing factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rbpmsprovided by RGD
Official Full Name: RNA binding protein, mRNA processing factorprovided by RGD
Primary source: RGD:1561067
See related: Ensembl:ENSRNOG00000013328 AllianceGenome:RGD:1561067
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RBP-MS; RGD1561067
Summary: Predicted to enable RNA binding activity; protein homodimerization activity; and transcription coactivator activity. Predicted to be involved in positive regulation of SMAD protein signal transduction; positive regulation of pathway-restricted SMAD protein phosphorylation; and response to oxidative stress. Predicted to be located in cytoplasmic stress granule; cytosol; and nucleoplasm. Orthologous to human RBPMS (RNA binding protein, mRNA processing factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 84.8), Kidney (RPKM 71.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.2-q12.3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (64942159..65098504)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (58239370..58395424)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (61954569..62109998)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate RNA-Binding Protein with Multiple Splicing (RBPMS) as a critical regulator of numerous alternative splicing (AS) events in vascular smooth muscle cells (SMCs)
Title: Identification of RBPMS as a mammalian smooth muscle master splicing regulator via proximity of its gene with super-enhancers.
The data indicate that in the retina RBPMS is selectively expressed in RGCs and therefore could serve as a marker for RGC quantification in normal retinas and for estimation of RGC loss in ocular neuropathies.
Title: RNA binding protein with multiple splicing: a new marker for retinal ganglion cells.

Submit: New GeneRIF Correction

General gene information

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Markers

Rbpms (e-PCR), detects polymorphism
- UniSTS:479243

Rbpms (e-PCR), detects polymorphism
- UniSTS:465492

AI011370 (e-PCR)
- UniSTS:250045

RH144171 (e-PCR)
- UniSTS:233417

AI231834 (e-PCR)
- UniSTS:250103

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA CDS binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables pre-mRNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables pre-mRNA intronic binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in P-body	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RNA-binding protein with multiple splicing

Names: RNA binding protein gene with multiple splicing; RNA binding protein with multiple splicing

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271244.1 → NP_001258173.1 RNA-binding protein with multiple splicing

See identical proteins and their annotated locations for NP_001258173.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

F2Z3S5

Related

ENSRNOP00000017883.4, ENSRNOT00000017883.6

Conserved Domains (1) summary

cd12682
Location:23 → 98

RRM_RBPMS; RNA recognition motif (RRM) found in vertebrate RNA-binding protein with multiple splicing (RBP-MS)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

64942159..65098504

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006253241.5 → XP_006253303.1 RNA-binding protein with multiple splicing isoform X3

Conserved Domains (1) summary

cd12682
Location:23 → 98

RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
XM_006253238.5 → XP_006253300.1 RNA-binding protein with multiple splicing isoform X1

Related

ENSRNOP00000081138.1

Conserved Domains (1) summary

cd12682
Location:23 → 98

RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
XM_006253240.5 → XP_006253302.1 RNA-binding protein with multiple splicing isoform X2

See identical proteins and their annotated locations for XP_006253302.1

UniProtKB/Swiss-Prot

A0A8I5ZR01, A0A8I6G705, F1M9Y9

UniProtKB/TrEMBL

A0A8I6AAP9

Related

ENSRNOP00000080717.1

Conserved Domains (1) summary

cd12682
Location:23 → 98

RRM_RBPMS; RNA recognition motif (RRM) found in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
XM_063275646.1 → XP_063131716.1 RNA-binding protein with multiple splicing isoform X2

UniProtKB/Swiss-Prot

A0A8I5ZR01, A0A8I6G705, F1M9Y9