Efhd1 EF-hand domain family, member D1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Efhd1provided by RGD
Official Full Name: EF-hand domain family, member D1provided by RGD
Primary source: RGD:1559565
See related: Ensembl:ENSRNOG00000015596 AllianceGenome:RGD:1559565
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1559565
Summary: Predicted to enable calcium ion sensor activity. Predicted to be involved in regulation of cellular hyperosmotic salinity response. Predicted to act upstream of or within neuron projection development. Predicted to be active in mitochondrial inner membrane. Orthologous to human EFHD1 (EF-hand domain family member D1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 235.2), Testes (RPKM 158.0) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q35

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (95386155..95432800)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (87938259..87984917)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (94362249..94408884)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D17S1789 (e-PCR)
- UniSTS:21272

RH130095 (e-PCR)
- UniSTS:213383

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion sensor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion sensor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular hyperosmotic salinity response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: EF-hand domain-containing protein D1

Names: EF hand domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109310.1 → NP_001102780.1 EF-hand domain-containing protein D1

See identical proteins and their annotated locations for NP_001102780.1

Status: PROVISIONAL

Source sequence(s)

CH474004

UniProtKB/TrEMBL

A6JWM1, D4A9T5

Related

ENSRNOP00000021168.4, ENSRNOT00000021168.6

Conserved Domains (1) summary

cd00051
Location:95 → 153

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

95386155..95432800

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039084118.2 → XP_038940046.1 EF-hand domain-containing protein D1 isoform X1

Conserved Domains (1) summary

cd00051
Location:95 → 153

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_006245468.4 → XP_006245530.1 EF-hand domain-containing protein D1 isoform X3

UniProtKB/TrEMBL

A0A8I6ASV0

Related

ENSRNOP00000096620.1

Conserved Domains (2) summary

cd00051
Location:95 → 153

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:96 → 153

EF-hand_7; EF-hand domain pair
XM_039084119.2 → XP_038940047.1 EF-hand domain-containing protein D1 isoform X2

Conserved Domains (1) summary

cd00051
Location:95 → 153

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...