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    Utp15 UTP15, small subunit processome component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310019, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Utp15provided by RGD
    Official Full Name
    UTP15, small subunit processome componentprovided by RGD
    Primary source
    RGD:1310992
    See related
    Ensembl:ENSRNOG00000016591 AllianceGenome:RGD:1310992
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310992
    Summary
    Predicted to be involved in positive regulation of rRNA processing; positive regulation of transcription by RNA polymerase I; and rRNA processing. Predicted to be located in endoplasmic reticulum and fibrillar center. Predicted to be active in nucleolus. Orthologous to human UTP15 (UTP15 small subunit processome component). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 66.6), Spleen (RPKM 57.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (31329222..31347022, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (29594405..29612819, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (28351925..28370315, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA40 Neighboring gene Rho guanine nucleotide exchange factor 28 Neighboring gene uncharacterized LOC134485583 Neighboring gene ankyrin repeat family A member 2 Neighboring gene basic transcription factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Interaction, mobility, and phosphorylation of human orthologues of WD repeat-containing components of the yeast SSU processome t-UTP sub-complex. Sato M, et al. Biochem Cell Biol, 2013 Dec. PMID 24219289
    2. Recruitment of factors linking transcription and processing of pre-rRNA to NOR chromatin is UBF-dependent and occurs independent of transcription in human cells. Prieto JL, et al. Genes Dev, 2007 Aug 15. PMID 17699751, Free PMC Article
    3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in positive regulation of rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    U3 small nucleolar RNA-associated protein 15 homolog
    Names
    UTP15 SSU processome component
    UTP15, U3 small nucleolar ribonucleoprotein, homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107647.2 → NP_001101117.1  U3 small nucleolar RNA-associated protein 15 homolog

      See identical proteins and their annotated locations for NP_001101117.1

      Status: PROVISIONAL

      Source sequence(s)
      BC131851
      UniProtKB/Swiss-Prot
      A2RRU3
      UniProtKB/TrEMBL
      A0A8I6B2C6, A6I536
      Conserved Domains (3) summary
      cd00200
      Location:39 → 298
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:41 → 78
      7WD40; WD40 repeat [structural motif]
      pfam09384
      Location:344 → 490
      UTP15_C; UTP15 C terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      31329222..31347022 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102170.2 → XP_038958098.1  U3 small nucleolar RNA-associated protein 15 homolog isoform X1

      UniProtKB/Swiss-Prot
      A2RRU3
      UniProtKB/TrEMBL
      A0A8I6B2C6, A6I536
      Related
      ENSRNOP00000022259.5
      Conserved Domains (3) summary
      cd00200
      Location:39 → 298
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:41 → 78
      7WD40; WD40 repeat [structural motif]
      pfam09384
      Location:344 → 490
      UTP15_C; UTP15 C terminal

    2. XM_063281718.1 → XP_063137788.1  U3 small nucleolar RNA-associated protein 15 homolog isoform X1

      UniProtKB/Swiss-Prot
      A2RRU3
      UniProtKB/TrEMBL
      A6I536
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2RRU3.1 GenPept UniProtKB/Swiss-Prot:A2RRU3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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