Ddx17 DEAD-box helicase 17 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ddx17provided by RGD
Official Full Name: DEAD-box helicase 17provided by RGD
Primary source: RGD:1304945
See related: Ensembl:ENSRNOG00000051170 AllianceGenome:RGD:1304945
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA helicase activity; long noncoding RNA binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including RNA metabolic process; intracellular steroid hormone receptor signaling pathway; and regulation of RNA metabolic process. Predicted to be located in nuclear speck. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleus. Orthologous to human DDX17 (DEAD-box helicase 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 1158.2), Lung (RPKM 966.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (112971522..112989747, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (111091127..111109353, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (120761843..120765012, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH127676 (e-PCR)
- UniSTS:210986

15.MHAa64f3.seq (e-PCR)
- UniSTS:123243

BM387078 (e-PCR)
- UniSTS:261251

C80929 (e-PCR)
- UniSTS:160470

AA819656 (e-PCR)
- UniSTS:243451

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin DNA binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lncRNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoprotein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in intracellular estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in miRNA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of skeletal muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: probable ATP-dependent RNA helicase DDX17

Names: DEAD (Asp-Glu-Ala-Asp) box helicase 17; DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

NP_001015018.1

EC 3.6.4.13

NP_001359065.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001015018.2 → NP_001015018.1 probable ATP-dependent RNA helicase DDX17 isoform 2

See identical proteins and their annotated locations for NP_001015018.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks most of the exons in the coding region, compared to transcript variant 1. The resulting protein (isoform 2) is much shorter with a different N-terminus when compared to isoform 1.

Source sequence(s)

FQ236955, JAXUCZ010000007

UniProtKB/TrEMBL

A6HSS5, Q568Z8

Conserved Domains (1) summary

PTZ00110
Location:22 → 118

PTZ00110; helicase; Provisional
NM_001372136.1 → NP_001359065.1 probable ATP-dependent RNA helicase DDX17 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

FQ236955, JAXUCZ010000007

UniProtKB/TrEMBL

A0A096MIX2, A6HSS3, E9PT29

Related

ENSRNOP00000018185.8, ENSRNOT00000018185.8

Conserved Domains (1) summary

PTZ00110
Location:32 → 502

PTZ00110; helicase; Provisional