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    Prl8a9 prolactin family 8, subfamily A, member 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171406, updated on 29-Feb-2024

    Summary

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    Official Symbol
    Prl8a9provided by RGD
    Official Full Name
    prolactin family 8, subfamily A, member 9provided by RGD
    Primary source
    RGD:619862
    See related
    Ensembl:ENSRNOG00000024843 AllianceGenome:RGD:619862
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ghd9; Prlpc2; Plpcbeta
    Summary
    Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (prolactin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Prl8a9 in Genome Data Viewer
    Location:
    17p12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (37503450..37509258)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (37295054..37300862)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (39241133..39246941)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene prolactin family 7, subfamily B, member 1 Neighboring gene prolactin family 8, subfamily a, member 1 Neighboring gene prolactin family 3, subfamily D, member 4 Neighboring gene prolactin family 8, subfamily A, member 9, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a new member of the placental prolactin-like protein-C (PLP-C) subfamily, PLP-Cbeta. Hwang IT, et al. Endocrinology, 2000 Sep. PMID 10965907
    2. Curated eutherian third party data gene data sets. Premzl M. Data Brief, 2016 Mar. PMID 26862561, Free PMC Article
    3. Third party data gene data set of eutherian growth hormone genes. Premzl M. Genom Data, 2015 Dec. PMID 26697363, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prolactin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in female pregnancy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mammary gland development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of lactation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to nutrient levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    prolactin-8A9
    Names
    PLP C-beta
    PLP-C2
    PRL-like protein C2
    growth hormone d9
    placental prolactin-like protein C2
    prolactin-like protein C 2
    prolactin-like protein C-beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134385.2 → NP_599212.1  prolactin-8A9 precursor

      See identical proteins and their annotated locations for NP_599212.1

      Status: PROVISIONAL

      Source sequence(s)
      AF239747
      UniProtKB/Swiss-Prot
      A1L118, Q498N7, Q80ZD4, Q920H9, Q920I0
      UniProtKB/TrEMBL
      A0A0M6L0Y1
      Related
      ENSRNOP00000038096.2, ENSRNOT00000034490.5
      Conserved Domains (1) summary
      cd10288
      Location:31 → 241
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      37503450..37509258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253905.1 → XP_006253967.1  prolactin-8A9 isoform X2

      See identical proteins and their annotated locations for XP_006253967.1

      UniProtKB/TrEMBL
      A6J7R2
      Related
      ENSRNOP00000096984.1, ENSRNOT00000104281.1
      Conserved Domains (1) summary
      cd10288
      Location:31 → 228
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    2. XM_006253904.1 → XP_006253966.1  prolactin-8A9 isoform X1

      See identical proteins and their annotated locations for XP_006253966.1

      UniProtKB/Swiss-Prot
      Q920I0
      Conserved Domains (1) summary
      cd10288
      Location:30 → 240
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q920I0.1 GenPept UniProtKB/Swiss-Prot:Q920I0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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