Myo1d myosin ID [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myo1dprovided by RGD
Official Full Name: myosin IDprovided by RGD
Primary source: RGD:621321
See related: Ensembl:ENSRNOG00000003276 AllianceGenome:RGD:621321
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Myr2; Myr4; Myo1c
Summary: Enables several functions, including actin filament binding activity; calcium-dependent protein binding activity; and calmodulin binding activity. Involved in forebrain development. Located in several cellular components, including apical dendrite; axolemma; and basolateral plasma membrane. Part of myosin complex. Orthologous to human MYO1D (myosin ID). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 161.9), Kidney (RPKM 149.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (65986900..66263538, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (65489153..65765812, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (67866939..68142864, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonistrated that myosin ID is expressed in myelinating oligodendrocytes in rat nerve system.
Title: Unconventional myosin ID is expressed in myelinating oligodendrocytes.
In conclusion, for the surface loops of Myo1c explored to date, the parent myosin dominates the behavior and loop 1 modulates the properties of the parent myosin. The loops themselves do not confer predictable properties on the parent myosin.
Title: Modification of loop 1 affects the nucleotide binding properties of Myo1c, the adaptation motor in the inner ear.
At apical surfaces of supporting cells surrounding hair cells in auditory epithelia of postnatal rats. In vestibular epithelia, in a ring within apical pole of hair cell. Prominent only immediately after birth.
Title: Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia.
Results describe Myo1d ATPase activity as a function of its IQ-motifs and calcium-calmodulin binding.
Title: The two IQ-motifs and Ca2+/calmodulin regulate the rat myosin 1d ATPase activity.
Results support a model in which Myo1c possesses a strain-sensing ADP-release mechanism, which allows it to adapt to mechanical load.
Title: Myo1c is designed for the adaptation response in the inner ear.
Myr4 mRNA was abundant in spinal cord motor neurons
Title: Axonal isoforms of myosin-I.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF386417 (e-PCR)
- UniSTS:243727

BI274510 (e-PCR)
- UniSTS:249121

D10Chm124 (e-PCR)
- UniSTS:518022

RH128556 (e-PCR)
- UniSTS:211864

BI292081 (e-PCR)
- UniSTS:245144

D10Rat29 (e-PCR)
- UniSTS:118172

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent protein binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in early endosome to recycling endosome transport	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in forebrain development	IEP Inferred from Expression Pattern more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in apical dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in axolemma	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in brush border	IEA Inferred from Electronic Annotation more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
located_in myelin sheath	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath	IEA Inferred from Electronic Annotation more info
located_in myelin sheath	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	ISS Inferred from Sequence or Structural Similarity more info
part_of myosin complex	IDA Inferred from Direct Assay more info	PubMed
part_of myosin complex	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane raft	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: unconventional myosin-Id

Names: Unconventional myosin from rat 4 for myosin I heavy chain; myosin 1C; myosin IC; myosin heavy chain myr 4; myosin-Id; myosin1C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012983.2 → NP_037115.2 unconventional myosin-Id

See identical proteins and their annotated locations for NP_037115.2

Status: PROVISIONAL

Source sequence(s)

BC087027

UniProtKB/Swiss-Prot

Q5PQU2, Q63357

UniProtKB/TrEMBL

A6HHC1

Related

ENSRNOP00000004609.3, ENSRNOT00000004609.5

Conserved Domains (2) summary

cd01378
Location:24 → 682

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:803 → 996

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

65986900..66263538 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268469.1 → XP_063124539.1 unconventional myosin-Id isoform X1

UniProtKB/TrEMBL

A0A8I6GJN3
XM_063268468.1 → XP_063124538.1 unconventional myosin-Id isoform X1

UniProtKB/TrEMBL

A0A8I6GJN3