Slc48a1 solute carrier family 48 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc48a1provided by RGD
Official Full Name: solute carrier family 48 member 1provided by RGD
Primary source: RGD:1562880
See related: Ensembl:ENSRNOG00000053196 AllianceGenome:RGD:1562880
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hrg1; HRG-1
Summary: Predicted to enable heme binding activity and heme transmembrane transporter activity. Predicted to be involved in heme transport. Predicted to be located in endosome membrane. Predicted to be active in lysosomal membrane and plasma membrane. Orthologous to human SLC48A1 (solute carrier family 48 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 321.8), Spleen (RPKM 317.0) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 7q36

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (130794233..130802119)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (128915136..128923929)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (139271698..139279499)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HRG-1 regulates V-ATPase activity, which is essential for endosomal acidification, heme binding, and receptor trafficking in mammalian cells.
Title: Heme-binding protein HRG-1 is induced by insulin-like growth factor I and associates with the vacuolar H+-ATPase to control endosomal pH and receptor trafficking.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables heme transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables heme transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in erythrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in heme export	ISO Inferred from Sequence Orthology more info
involved_in heme export from vacuole to cytoplasm	IEA Inferred from Electronic Annotation more info
involved_in heme export from vacuole to cytoplasm	ISO Inferred from Sequence Orthology more info
involved_in heme metabolic process	IEA Inferred from Electronic Annotation more info
involved_in heme metabolic process	ISO Inferred from Sequence Orthology more info
involved_in heme transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heme transport	ISO Inferred from Sequence Orthology more info
involved_in heme transport	ISO Inferred from Sequence Orthology more info
involved_in localization of cell	ISO Inferred from Sequence Orthology more info
involved_in lysosomal transport	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endolysosome	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in phagolysosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: heme transporter HRG1

Names: Heme-responsive gene 1 protein homolog; solute carrier family 48 (heme transporter), member 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127456.1 → NP_001120928.1 heme transporter HRG1

See identical proteins and their annotated locations for NP_001120928.1

Status: PROVISIONAL

Source sequence(s)

BC158869

UniProtKB/Swiss-Prot

B0BNL4, Q3KR77

UniProtKB/TrEMBL

A0A8L2R3J2

Related

ENSRNOP00000093159.1, ENSRNOT00000110329.1

Conserved Domains (1) summary

pfam16954
Location:72 → 122

HRG; Haem-transporter, endosomal/lysosomal, haem-responsive gene

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

130794233..130802119

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078912.2 → XP_038934840.1 heme transporter HRG1 isoform X1

Conserved Domains (1) summary

pfam16954
Location:10 → 66

HRG; Haem-transporter, endosomal/lysosomal, haem-responsive gene