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    Ythdf2 YTH N6-methyladenosine RNA binding protein F2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313053, updated on 4-Apr-2024

    Summary

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    Official Symbol
    Ythdf2provided by RGD
    Official Full Name
    YTH N6-methyladenosine RNA binding protein F2provided by RGD
    Primary source
    RGD:1311321
    See related
    Ensembl:ENSRNOG00000010892 AllianceGenome:RGD:1311321
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable C5-methylcytidine-containing RNA binding activity; N6-methyladenosine-containing RNA binding activity; and mRNA binding activity. Predicted to be involved in several processes, including gamete generation; regulation of gene expression; and regulation of stem cell differentiation. Predicted to be located in several cellular components, including centriolar satellite; cytoplasmic ribonucleoprotein granule; and cytosol. Predicted to be active in cytoplasm. Orthologous to human YTHDF2 (YTH N6-methyladenosine RNA binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 185.8), Spleen (RPKM 165.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ythdf2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (149665467..149693127, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (144381426..144407126, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (150364490..150390173, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 200B Neighboring gene erythrocyte membrane protein band 4.1 Neighboring gene opioid receptor, delta 1 Neighboring gene glucocorticoid modulatory element binding protein 1 Neighboring gene U11 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion. Li Z, et al. Cell Res, 2018 Sep. PMID 30065315, Free PMC Article
    2. The RNA m(6)A Reader YTHDF2 Is Essential for the Post-transcriptional Regulation of the Maternal Transcriptome and Oocyte Competence. Ivanova I, et al. Mol Cell, 2017 Sep 21. PMID 28867294, Free PMC Article
    3. Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine. Zhu T, et al. Cell Res, 2014 Dec. PMID 25412661, Free PMC Article
    4. Structure of the YTH domain of human YTHDF2 in complex with an m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition. Li F, et al. Cell Res, 2014 Dec. PMID 25412658, Free PMC Article
    5. Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner. Chen Y, et al. Mol Med, 2023 Feb 6. PMID 36747144, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. YTHDF2-regulated matrilin-3 mitigates post-reperfusion hemorrhagic transformation in ischemic stroke via the PI3K/AKT pathway.
      Title: YTHDF2-regulated matrilin-3 mitigates post-reperfusion hemorrhagic transformation in ischemic stroke via the PI3K/AKT pathway.
    2. Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner.
      Title: Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner.
    3. METTL3 promotes prostatic hyperplasia by regulating PTEN expression in an m(6)A-YTHDF2-dependent manner.
      Title: METTL3 promotes prostatic hyperplasia by regulating PTEN expression in an m(6)A-YTHDF2-dependent manner.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables C5-methylcytidine-containing RNA reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N6-methyladenosine-containing RNA reader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N6-methyladenosine-containing RNA reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in gamete generation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hematopoietic stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA destabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oocyte maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in organelle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cap-independent translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in positive regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of hematopoietic stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mRNA stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of meiotic cell cycle process involved in oocyte maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogonial cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    YTH domain-containing family protein 2
    Names
    YTH N(6)-methyladenosine RNA binding protein 2
    YTH domain family 2
    YTH domain family protein 2
    YTH domain family, member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047099.3 → NP_001040564.2  YTH domain-containing family protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      B2GUU1, E9PU11
      Related
      ENSRNOP00000090745.1, ENSRNOT00000111641.1
      Conserved Domains (1) summary
      pfam04146
      Location:411 → 544
      YTH; YT521-B-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      149665467..149693127 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109798.2 → XP_038965726.1  YTH domain-containing family protein 2 isoform X1

      UniProtKB/TrEMBL
      Q1JU70
      Conserved Domains (1) summary
      pfam04146
      Location:411 → 544
      YTH; YT521-B-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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