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    Rhbdl3 rhomboid like 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287556, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rhbdl3provided by RGD
    Official Full Name
    rhomboid like 3provided by RGD
    Primary source
    RGD:1311901
    See related
    Ensembl:ENSRNOG00000005515 AllianceGenome:RGD:1311901
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rhbdl4
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be integral component of membrane. Orthologous to human RHBDL3 (rhomboid like 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 56.4), Thymus (RPKM 47.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rhbdl3 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (65797145..65851949)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (65299250..65354099)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (67676999..67731670)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480832 Neighboring gene ring finger protein 135 Neighboring gene ras homolog family member T1 Neighboring gene similar to human chromosome 17 open reading frame 75 Neighboring gene microRNA 632 Neighboring gene zinc finger protein 207

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rhomboid-related protein 3
    Names
    rhomboid protease 3
    rhomboid, veinlet-like 3
    rhomboid, veinlet-like 4
    NP_001099289.1
    XP_006247042.1
    XP_006247044.1
    XP_017452606.1
    XP_038941472.1
    XP_038941473.1
    XP_063124756.1
    XP_063124757.1
    XP_063124758.1
    XP_063124759.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105819.1 → NP_001099289.1  rhomboid-related protein 3

      See identical proteins and their annotated locations for NP_001099289.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HHB1, D4AAW6
      Related
      ENSRNOP00000007312.4, ENSRNOT00000007312.5
      Conserved Domains (2) summary
      pfam01694
      Location:205 → 359
      Rhomboid; Rhomboid family
      pfam13499
      Location:36 → 100
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      65797145..65851949
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246982.5 → XP_006247044.1  rhomboid-related protein 3 isoform X2

      Conserved Domains (3) summary
      pfam01694
      Location:205 → 313
      Rhomboid; Rhomboid family
      pfam13499
      Location:42 → 99
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:40 → 100
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. XM_039085545.2 → XP_038941473.1  rhomboid-related protein 3 isoform X8

      Conserved Domains (2) summary
      pfam13499
      Location:36 → 100
      EF-hand_7; EF-hand domain pair
      cl21536
      Location:205 → 260
      Rhomboid; Rhomboid family

    3. XM_017597117.3 → XP_017452606.1  rhomboid-related protein 3 isoform X3

    4. XM_063268689.1 → XP_063124759.1  rhomboid-related protein 3 isoform X9

    5. XM_063268686.1 → XP_063124756.1  rhomboid-related protein 3 isoform X4

    6. XM_039085544.2 → XP_038941472.1  rhomboid-related protein 3 isoform X6

      Conserved Domains (2) summary
      pfam01694
      Location:205 → 294
      Rhomboid; Rhomboid family
      pfam13499
      Location:36 → 100
      EF-hand_7; EF-hand domain pair

    7. XM_063268688.1 → XP_063124758.1  rhomboid-related protein 3 isoform X7

    8. XM_063268687.1 → XP_063124757.1  rhomboid-related protein 3 isoform X5

    9. XM_006246980.5 → XP_006247042.1  rhomboid-related protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AK12
      Related
      ENSRNOP00000094633.1
      Conserved Domains (2) summary
      pfam01694
      Location:197 → 351
      Rhomboid; Rhomboid family
      cl08302
      Location:36 → 92
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein Strain
    Heading Accession and Version

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