Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hsd17b7provided by RGD
Official Full Name: hydroxysteroid (17-beta) dehydrogenase 7provided by RGD
Primary source: RGD:2837
See related: Ensembl:ENSRNOG00000002826 AllianceGenome:RGD:2837
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables estradiol 17-beta-dehydrogenase activity and prolactin receptor binding activity. Involved in several processes, including estrogen biosynthetic process; response to estradiol; and response to prolactin. Located in membrane. Biomarker of polycystic ovary syndrome. Orthologous to human HSD17B7 (hydroxysteroid 17-beta dehydrogenase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 72.6), Brain (RPKM 36.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (84702875..84722810, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (82170079..82190018, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (88288116..88308019, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stroke-prone spontaneously hypertensive rats have reduced hydroxysteroid 17-beta dehydrogenase 7 levels for low cholesterol biosynthesis.
Title: Stroke-prone spontaneously hypertensive rats have reduced hydroxysteroid 17-β dehydrogenase 7 levels for low cholesterol biosynthesis.
This study showed that Effect of hyperprolactinemia on PRL-receptor expression in the prostate of long-term sexually-active rats.
Title: Effect of hyperprolactinemia on PRL-receptor expression and activation of Stat and Mapk cell signaling in the prostate of long-term sexually-active rats.
identification of the promoter elements involved in the basal expression of PRAP/17betaHSD7
Title: Cloning and characterization of a 5' regulatory region of the prolactin receptor-associated protein/17{beta} hydroxysteroid dehydrogenase 7 gene.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-keto sterol reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-keto sterol reductase activity	IEA Inferred from Electronic Annotation more info
enables 3-keto sterol reductase activity	ISO Inferred from Sequence Orthology more info
enables 3-keto sterol reductase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 5alpha-androstane-3beta,17beta-diol dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5alpha-androstane-3beta,17beta-diol dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables 5alpha-androstane-3beta,17beta-diol dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables 5alpha-androstane-3beta,17beta-diol dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity	IBA Inferred from Biological aspect of Ancestor more info
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity	IDA Inferred from Direct Assay more info	PubMed
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity	IEA Inferred from Electronic Annotation more info
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity	ISO Inferred from Sequence Orthology more info
enables prolactin receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in androgen metabolic process	IEA Inferred from Electronic Annotation more info
involved_in androgen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in androgen metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in brain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cholesterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic organ development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in estrogen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in estrogen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in estrogen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in maternal process involved in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within nervous system development	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to prolactin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in steroid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

Names: 17-beta-HSD 7; 17-beta-hydroxysteroid dehydrogenase 7; 3-keto-steroid reductase; PRAP; PRL receptor-associated protein; dihydrotestosterone oxidoreductase; estradiol 17-beta-dehydrogenase 7; hydroxysteroid dehydrogenase 17 beta, type 7; prolactin receptor-associated protein

NP_058931.1

EC 1.1.1.210

EC 1.1.1.270

EC 1.1.1.62

XP_006250277.1

EC 1.1.1.210

EC 1.1.1.270

EC 1.1.1.62

XP_006250278.1

EC 1.1.1.210

EC 1.1.1.270

EC 1.1.1.62

XP_006250279.1

EC 1.1.1.210

EC 1.1.1.270

EC 1.1.1.62

XP_017454261.1

EC 1.1.1.210

EC 1.1.1.270

EC 1.1.1.62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429538.1 → NP_001416467.1 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013
NM_001429539.1 → NP_001416468.1 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013
NM_001429540.1 → NP_001416469.1 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013
NM_017235.3 → NP_058931.1 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

See identical proteins and their annotated locations for NP_058931.1

Status: VALIDATED

Source sequence(s)

FM073997, FN803430, JAXUCZ010000013

UniProtKB/Swiss-Prot

Q62904

UniProtKB/TrEMBL

A0A8I6AU17

Related

ENSRNOP00000095732.1, ENSRNOT00000111937.1

Conserved Domains (2) summary

cd08941
Location:2 → 280

3KS_SDR_c; 3-keto steroid reductase, classical (c) SDRs

COG1028
Location:1 → 271

FabG; NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

84702875..84722810 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017598772.3 → XP_017454261.1 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 isoform X2

UniProtKB/TrEMBL

A0A8I6AU17
XM_006250217.5 → XP_006250279.1 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 isoform X1

UniProtKB/TrEMBL

A0A0H2UHB1, A0A8I6AU17, A6IDN2

Conserved Domains (2) summary

cd08941
Location:3 → 281

3KS_SDR_c; 3-keto steroid reductase, classical (c) SDRs

COG1028
Location:1 → 272

FabG; NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
XM_006250216.5 → XP_006250278.1 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 isoform X1

UniProtKB/TrEMBL

A0A0H2UHB1, A0A8I6AU17, A6IDN2

Conserved Domains (2) summary

cd08941
Location:3 → 281

3KS_SDR_c; 3-keto steroid reductase, classical (c) SDRs

COG1028
Location:1 → 272

FabG; NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
XM_006250215.5 → XP_006250277.1 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 isoform X1

UniProtKB/TrEMBL

A0A0H2UHB1, A0A8I6AU17, A6IDN2

Related

ENSRNOP00000003812.5

Conserved Domains (2) summary

cd08941
Location:3 → 281

3KS_SDR_c; 3-keto steroid reductase, classical (c) SDRs

COG1028
Location:1 → 272

FabG; NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]