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    Rc3h2 ring finger and CCCH-type domains 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311909, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rc3h2provided by RGD
    Official Full Name
    ring finger and CCCH-type domains 2provided by RGD
    Primary source
    RGD:1304833
    See related
    Ensembl:ENSRNOG00000009196 AllianceGenome:RGD:1304833
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mnab
    Summary
    Predicted to enable nucleic acid binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including T cell receptor signaling pathway; cellular macromolecule catabolic process; and negative regulation of T-helper 17 cell differentiation. Predicted to act upstream of or within several processes, including hematopoietic or lymphoid organ development; lymphocyte homeostasis; and positive regulation of NIK/NF-kappaB signaling. Predicted to be located in cell surface; intracellular membrane-bounded organelle; and membrane. Predicted to be active in cytoplasmic stress granule. Orthologous to human RC3H2 (ring finger and CCCH-type domains 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 250.5), Brain (RPKM 221.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rc3h2 in Genome Data Viewer
    Location:
    3q11
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (41531319..41596496, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (21121531..21186711, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (21621976..21676789, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101901 Neighboring gene phosducin like Neighboring gene NME/NM23 nucleoside diphosphate kinase 2, pseudogene 2 Neighboring gene small nucleolar RNA, C/D box 90 Neighboring gene zinc finger and BTB domain containing 6 like 1 Neighboring gene uncharacterized LOC108350365 Neighboring gene zinc finger and BTB domain containing 6 Neighboring gene zinc finger and BTB domain containing 26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure of human Roquin-2 and its complex with constitutive-decay element RNA. Sakurai S, et al. Acta Crystallogr F Struct Biol Commun, 2015 Aug. PMID 26249698, Free PMC Article
    2. A human gene coding for a membrane-associated nucleic acid-binding protein. Siess DC, et al. J Biol Chem, 2000 Oct 27. PMID 10938276
    3. Roquin-2 promotes ubiquitin-mediated degradation of ASK1 to regulate stress responses. Maruyama T, et al. Sci Signal, 2014 Jan 21. PMID 24448648
    4. Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis. Srivastava M, et al. Nat Commun, 2015 Feb 20. PMID 25697406, Free PMC Article
    5. Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation. Jeltsch KM, et al. Nat Immunol, 2014 Nov. PMID 25282160

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA stem-loop binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA stem-loop binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within T cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within T follicular helper cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within limb development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lung alveolus development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lymph node development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T-helper 17 cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within post-transcriptional regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of miRNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spleen development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in P-body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    roquin-2
    Names
    RING finger and CCCH-type zinc finger domain-containing protein 2
    membrane associated DNA binding protein
    ring finger and CCCH-type zinc finger domains 2
    NP_001101309.1
    XP_008759976.1
    XP_038961197.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107839.1 → NP_001101309.1  roquin-2

      See identical proteins and their annotated locations for NP_001101309.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473983
      UniProtKB/TrEMBL
      A6JET0
      Conserved Domains (2) summary
      pfam00642
      Location:411 → 437
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam14634
      Location:14 → 55
      zf-RING_5; zinc-RING finger domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      41531319..41596496 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105269.2 → XP_038961197.1  roquin-2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K9L3
      Related
      ENSRNOP00000075040.2
      Conserved Domains (5) summary
      PTZ00449
      Location:523 → 796
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      COG5063
      Location:393 → 457
      CTH1; CCCH-type Zn-finger protein [General function prediction only]
      cd16638
      Location:11 → 54
      mRING-HC-C3HC3D_Roquin; Modified RING finger, HC subclass (C3HC3D-type), found in Roquin-1, Roquin-2, and similar proteins
      pfam00642
      Location:411 → 437
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18386
      Location:268 → 323
      ROQ_II; Roquin II domain

    2. XM_008761754.4 → XP_008759976.1  roquin-2 isoform X2

      UniProtKB/TrEMBL
      D3ZBM2
      Related
      ENSRNOP00000012354.6
      Conserved Domains (2) summary
      pfam00642
      Location:411 → 437
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam14634
      Location:14 → 55
      zf-RING_5; zinc-RING finger domain

    RNA

    1. XR_005501919.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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