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    Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308267, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Tab2provided by RGD
    Official Full Name
    TGF-beta activated kinase 1/MAP3K7 binding protein 2provided by RGD
    Primary source
    RGD:1309527
    See related
    Ensembl:ENSRNOG00000016054 AllianceGenome:RGD:1309527
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Map3k7ip2
    Summary
    Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and zinc ion binding activity. Predicted to be involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of protein kinase activity; and response to lipopolysaccharide. Predicted to be located in cytosol and membrane. Orthologous to human TAB2 (TGF-beta activated kinase 1 (MAP3K7) binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 106.9), Thymus (RPKM 102.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1p13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (4195400..4245485, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (2375026..2425115, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (1999574..2017574, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase like 4 Neighboring gene zinc finger CCCH type containing 12D Neighboring gene ETS variant transcription factor 5, pseudogene 1 Neighboring gene uncharacterized LOC108348767 Neighboring gene uronyl-2-sulfotransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Assigning pathogenicity for TAB2 variants using a novel scalable functional assay and expanding TAB2 disease spectrum. Xu W, et al. Hum Mol Genet, 2023 Mar 6. PMID 36229919, Free PMC Article
    2. In vivo therapeutic success of MicroRNA-155 antagomir in a mouse model of pulmonary fibrosis induced by bleomycin. Sun X, et al. Korean J Intern Med, 2021 Mar. PMID 32506869, Free PMC Article
    3. Protein molecular modeling techniques investigating novel TAB2 variant R347X causing cardiomyopathy and congenital heart defects in multigenerational family. Caulfield TR, et al. Mol Genet Genomic Med, 2018 Apr 26. PMID 29700987, Free PMC Article
    4. MiR-199a target regulates TAB2 to promote the migration of endodermal progenitor cells and inhibit deep vein thrombosis in rats. Ni X, et al. Minerva Pediatr (Torino), 2023 Feb. PMID 36322021
    5. Associations between TAB2 Gene Polymorphisms and Epithelial Ovarian Cancer in a Chinese Population. Huang X, et al. Dis Markers, 2019. PMID 31485280, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-199a target regulates TAB2 to promote the migration of endodermal progenitor cells and inhibit deep vein thrombosis in rats.
      Title: MiR-199a target regulates TAB2 to promote the migration of endodermal progenitor cells and inhibit deep vein thrombosis in rats.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables K63-linked polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables K63-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables K63-linked polyubiquitin modification-dependent protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
    Names
    TGF-beta-activated kinase 1-binding protein 2
    mitogen-activated protein kinase kinase kinase 7-interacting protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393814.1 → NP_001380743.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q5U303
      UniProtKB/TrEMBL
      A6JP22
      Related
      ENSRNOP00000021904.3, ENSRNOT00000021905.7
      Conserved Domains (4) summary
      smart00547
      Location:667 → 690
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:668 → 687
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam10473
      Location:541 → 619
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      4195400..4245485 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288633.1 → XP_063144703.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q5U303
      UniProtKB/TrEMBL
      A6JP22

    2. XM_039110915.2 → XP_038966843.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      Conserved Domains (1) summary
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins

    3. XM_039110917.2 → XP_038966845.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      Conserved Domains (1) summary
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins

    4. XM_039110921.2 → XP_038966849.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      Conserved Domains (1) summary
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins

    5. XM_039110919.2 → XP_038966847.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

      Conserved Domains (1) summary
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins

    6. XM_063288630.1 → XP_063144700.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001012062.1: Suppressed sequence

      Description
      NM_001012062.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U303.2 GenPept UniProtKB/Swiss-Prot:Q5U303

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