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    TXNRD1 thioredoxin reductase 1 [ Homo sapiens (human) ]

    Gene ID: 7296, updated on 11-Apr-2024

    Summary

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    Official Symbol
    TXNRD1provided by HGNC
    Official Full Name
    thioredoxin reductase 1provided by HGNC
    Primary source
    HGNC:HGNC:12437
    See related
    Ensembl:ENSG00000198431 MIM:601112; AllianceGenome:HGNC:12437
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TR; TR1; TXNR; TRXR1; TXNR1; GRIM-12
    Summary
    The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis. [provided by RefSeq, May 2017]
    Expression
    Ubiquitous expression in adrenal (RPKM 41.8), gall bladder (RPKM 31.2) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    12q23.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (104215779..104350307)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (104177472..104311962)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (104609557..104744085)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369947 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23741 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23744 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23747 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23754 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23756 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23757 Neighboring gene long intergenic non-protein coding RNA 2385 Neighboring gene Sharpr-MPRA regulatory region 15351 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:104609333-104609949 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:104609950-104610565 Neighboring gene NFE2L2 motif-containing MPRA enhancer 194 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23775 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23777 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:104628245-104628471 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23786 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23788 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23792 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23801 Neighboring gene uncharacterized LOC124903002 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23817 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:104665873-104667072 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23822 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23828 Neighboring gene ribosomal protein L18a pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 5029 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:104680011-104681210 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:104681597-104682144 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:104682145-104682690 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23836 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23840 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:104697445-104698317 Neighboring gene EP300 interacting inhibitor of differentiation 3 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23854 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:104736854-104737098 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23864 Neighboring gene Sharpr-MPRA regulatory region 7710 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:104761070-104761775 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:104765060-104765816 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:104765817-104766574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:104766575-104767330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:104768893-104769404 Neighboring gene uncharacterized LOC105369949 Neighboring gene MPRA-validated peak1927 silencer Neighboring gene uncharacterized LOC124903003

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Metabolism-Related Gene TXNRD1 Regulates Inflammation and Oxidative Stress Induced by Cigarette Smoke through the Nrf2/HO-1 Pathway in the Small Airway Epithelium. Huang Q, et al. Oxid Med Cell Longev, 2022. PMID 36578523, Free PMC Article
    2. Inhibition of thioredoxin reductase activity reduces the antioxidant defense capacity of human pluripotent stem cells under conditions of mild but not severe oxidative stress. Ivanova J, et al. Biochem Biophys Res Commun, 2023 Jan 29. PMID 36577250
    3. Selenite Ameliorates Cadmium-induced Cytotoxicity Through Downregulation of ROS Levels and Upregulation of Selenoprotein Thioredoxin Reductase 1 in SH-SY5Y Cells. Wang H, et al. Biol Trace Elem Res, 2023 Jan. PMID 35066751
    4. Correlation between TXNRD1/HO-1 expression and response to neoadjuvant chemoradiation therapy in patients with esophageal squamous cell carcinoma. Akaishi R, et al. Esophagus, 2022 Jul. PMID 34999996, Free PMC Article
    5. Thioredoxin reductase-1 levels are associated with NRF2 pathway activation and tumor recurrence in non-small cell lung cancer. Delgobo M, et al. Free Radic Biol Med, 2021 Dec. PMID 34673143

    See all (196) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif.
      Title: Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif.
    2. PSMD12 promotes non-small cell lung cancer progression through activating the Nrf2/TrxR1 pathway.
      Title: PSMD12 promotes non-small cell lung cancer progression through activating the Nrf2/TrxR1 pathway.
    3. A wide scan of plasma proteins demonstrates thioredoxin reductase 1 as a potential new diagnostic biomarker for hepatocellular carcinoma.
      Title: A wide scan of plasma proteins demonstrates thioredoxin reductase 1 as a potential new diagnostic biomarker for hepatocellular carcinoma.
    4. Keratinocytes Exposed to Blue or Red Light: Proteomic Characterization Showed Cytoplasmic Thioredoxin Reductase 1 and Aldo-Keto Reductase Family 1 Member C3 Triggered Expression.
      Title: Keratinocytes Exposed to Blue or Red Light: Proteomic Characterization Showed Cytoplasmic Thioredoxin Reductase 1 and Aldo-Keto Reductase Family 1 Member C3 Triggered Expression.
    5. TXNRD1 knockdown inhibits the proliferation of endothelial cells subjected to oscillatory shear stress via activation of the endothelial nitric oxide synthase/apoptosis pathway.
      Title: TXNRD1 knockdown inhibits the proliferation of endothelial cells subjected to oscillatory shear stress via activation of the endothelial nitric oxide synthase/apoptosis pathway.
    6. Combined thioredoxin reductase and glutaminase inhibition exerts synergistic anti-tumor activity in MYC-high high-grade serous ovarian carcinoma.
      Title: Combined thioredoxin reductase and glutaminase inhibition exerts synergistic anti-tumor activity in MYC-high high-grade serous ovarian carcinoma.
    7. Thioredoxin reductase 1 regulates hepatic inflammation and macrophage activation during acute cholestatic liver injury.
      Title: Thioredoxin reductase 1 regulates hepatic inflammation and macrophage activation during acute cholestatic liver injury.
    8. Inhibition of thioredoxin reductase activity reduces the antioxidant defense capacity of human pluripotent stem cells under conditions of mild but not severe oxidative stress.
      Title: Inhibition of thioredoxin reductase activity reduces the antioxidant defense capacity of human pluripotent stem cells under conditions of mild but not severe oxidative stress.
    9. Selenite Ameliorates Cadmium-induced Cytotoxicity Through Downregulation of ROS Levels and Upregulation of Selenoprotein Thioredoxin Reductase 1 in SH-SY5Y Cells.
      Title: Selenite Ameliorates Cadmium-induced Cytotoxicity Through Downregulation of ROS Levels and Upregulation of Selenoprotein Thioredoxin Reductase 1 in SH-SY5Y Cells.
    10. Metabolism-Related Gene TXNRD1 Regulates Inflammation and Oxidative Stress Induced by Cigarette Smoke through the Nrf2/HO-1 Pathway in the Small Airway Epithelium.
      Title: Metabolism-Related Gene TXNRD1 Regulates Inflammation and Oxidative Stress Induced by Cigarette Smoke through the Nrf2/HO-1 Pathway in the Small Airway Epithelium.
    Submit: New GeneRIF Correction See all GeneRIFs (123)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of selenium concentrations.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 assembly incorporates TXN (Trx1) and TXNRD1 (TrxR1) into viral particles PubMed
    HIV-1 IIIB requires thioredoxin reductase-1 (TrxR1) for virus entry; inhibition was shown through organotellurium inhibitor use PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 Env (gp120) requires thioredoxin-1 (Trx1); Env disulfide bonds are reduced by thioredoxin resulting in virus entry PubMed
    Tat tat Thioredoxin reductase-1 (TR1), a selenium-containing pyridine nucleotide-disulfide oxidoreductase, acts as a negative regulator of Tat-dependent transcription in a NF-kappaB-independent pathway PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC9145

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables FAD binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADPH peroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables thioredoxin-disulfide reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thioredoxin-disulfide reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mesoderm formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    thioredoxin reductase 1, cytoplasmic
    Names
    KM-102-derived reductase-like factor
    gene associated with retinoic and IFN-induced mortality 12 protein
    gene associated with retinoic and interferon-induced mortality 12 protein
    oxidoreductase
    peroxidase TXNRD1
    selenoprotein TXNRD1
    testis tissue sperm-binding protein Li 46a
    thioredoxin reductase GRIM-12
    thioredoxin reductase TR1
    NP_001087240.1
    NP_001248374.1
    NP_001248375.1
    NP_003321.3
    NP_877393.1
    NP_877419.1
    NP_877420.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029392.1 RefSeqGene

      Range
      4999..139527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001093771.3 → NP_001087240.1  thioredoxin reductase 1, cytoplasmic isoform 5

      See identical proteins and their annotated locations for NP_001087240.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7, also known as beta 1) represents use of an alternate upstream promoter, and contains additional exons at the 5' end compared to variant 1. The encoded isoform (5, also known as TXNRD1_v3 or v3) has a longer and distinct N-terminus, resulting from translation initiation at an in-frame upstream start codon, compared to isoform 1. It is predominantly expressed in Leydig cells of testis, and contains an atypical N-terminal glutaredoxin domain, which induces actin and tubulin polymerization, leading to formation of cell membrane protrusions (PMID:18042542).
      Source sequence(s)
      AI097548, AK226071, AY057105, BC018122, DC418649
      Consensus CDS
      CCDS53820.1
      UniProtKB/Swiss-Prot
      B7Z1F4, B7Z3Y8, B7Z904, E9PMY9, F5H780, Q16881, Q6FI31, Q6VB40, Q6VB41, Q6VB42, Q6VBP2, Q6VBP3, Q6VBP4, Q6VBP5, Q6VBP9, Q6VBQ0, Q6YNQ1, Q76P53, Q7LA96, Q8WVC8, Q99475, Q9UES8, Q9UH79
      UniProtKB/TrEMBL
      A0A140VKC9
      Related
      ENSP00000434516.1, ENST00000525566.6
      Conserved Domains (4) summary
      cd03419
      Location:68 → 148
      GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
      TIGR01438
      Location:161 → 649
      TGR; thioredoxin and glutathione reductase selenoprotein
      pfam00070
      Location:342 → 418
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:521 → 631
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain

    2. NM_001261445.2 → NP_001248374.1  thioredoxin reductase 1, cytoplasmic isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate donor splice site at the 5' terminal exon, which results in translation initiation from an in-frame upstream start codon compared to variant 1. The encoded isoform (3) has a longer and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AI097548, AK226071, AK295067, BC018122, DA440625, DC351122, DC400503
      UniProtKB/TrEMBL
      B7Z2S5
      Conserved Domains (4) summary
      TIGR01438
      Location:61 → 549
      TGR; thioredoxin and glutathione reductase selenoprotein
      pfam00070
      Location:242 → 318
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:421 → 531
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
      cl00388
      Location:1 → 48
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    3. NM_001261446.2 → NP_001248375.1  thioredoxin reductase 1, cytoplasmic isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an internal exon in the 5' region, which results in translation initiation from an in-frame downstream start codon compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AI097548, AK226071, AK293322, BC018122
      Consensus CDS
      CCDS58274.1
      UniProtKB/TrEMBL
      B2R5P6
      Related
      ENSP00000434919.1, ENST00000529546.5
      Conserved Domains (3) summary
      TIGR01438
      Location:1 → 461
      TGR; thioredoxin and glutathione reductase selenoprotein
      pfam00070
      Location:154 → 230
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:333 → 443
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain

    4. NM_003330.4 → NP_003321.3  thioredoxin reductase 1, cytoplasmic isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate donor splice site at the 5' terminal exon, which results in translation initiation from an in-frame upstream start codon compared to variant 1. The encoded isoform (2, also known as TXNRD1_v2) has a longer and distinct N-terminus, and is thought to differentially regulate genes associated with differentiation and adhesion compared to isoform 1 (PMID:26464515).
      Source sequence(s)
      AI097548, AK226071, BC018122, DC351122
      Consensus CDS
      CCDS53821.1
      UniProtKB/TrEMBL
      B7Z2S5
      Related
      ENSP00000435929.1, ENST00000526691.5
      Conserved Domains (4) summary
      TIGR01438
      Location:63 → 551
      TGR; thioredoxin and glutathione reductase selenoprotein
      pfam00070
      Location:244 → 320
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:423 → 533
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
      cl00388
      Location:4 → 50
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    5. NM_182729.3 → NP_877393.1  thioredoxin reductase 1, cytoplasmic isoform 1

      See identical proteins and their annotated locations for NP_877393.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1 (also known as TXNRD1_v1). This isoform is thought to regulate expression of genes associated with differentiation and adhesion (PMID:26464515). Variants 1-3 encode the same isoform.
      Source sequence(s)
      AI097548, AK226071, BC018122, DC400503
      Consensus CDS
      CCDS53823.1
      UniProtKB/TrEMBL
      B2R5P6
      Related
      ENSP00000421934.2, ENST00000503506.6
      Conserved Domains (3) summary
      TIGR01438
      Location:11 → 499
      TGR; thioredoxin and glutathione reductase selenoprotein
      pfam00070
      Location:192 → 268
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:371 → 481
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain

    6. NM_182742.3 → NP_877419.1  thioredoxin reductase 1, cytoplasmic isoform 1

      See identical proteins and their annotated locations for NP_877419.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same isoform (1, also known as TXNRD1_v1), which is thought to regulate expression of genes associated with differentiation and adhesion (PMID:26464515).
      Source sequence(s)
      AI097548, AK226071, BC018122, DA238692
      Consensus CDS
      CCDS53823.1
      UniProtKB/TrEMBL
      B2R5P6
      Conserved Domains (3) summary
      TIGR01438
      Location:11 → 499
      TGR; thioredoxin and glutathione reductase selenoprotein
      pfam00070
      Location:192 → 268
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:371 → 481
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain

    7. NM_182743.3 → NP_877420.1  thioredoxin reductase 1, cytoplasmic isoform 1

      See identical proteins and their annotated locations for NP_877420.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks a 5' non-coding exon; therefore, has a shorter 5' UTR compared to variant 1. Variants 1-3 encode the same isoform (1, also known as TXNRD1_v1), which is thought to regulate expression of genes associated with differentiation and adhesion (PMID:26464515).
      Source sequence(s)
      AI097548, AK226071, BC018122, DA319870
      Consensus CDS
      CCDS53823.1
      UniProtKB/TrEMBL
      B2R5P6
      Conserved Domains (3) summary
      TIGR01438
      Location:11 → 499
      TGR; thioredoxin and glutathione reductase selenoprotein
      pfam00070
      Location:192 → 268
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:371 → 481
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      104215779..104350307
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      104177472..104311962
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q16881.3 GenPept UniProtKB/Swiss-Prot:Q16881

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous