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    TNS1 tensin 1 [ Homo sapiens (human) ]

    Gene ID: 7145, updated on 7-Apr-2024

    Summary

    Official Symbol
    TNS1provided by HGNC
    Official Full Name
    tensin 1provided by HGNC
    Primary source
    HGNC:HGNC:11973
    See related
    Ensembl:ENSG00000079308 MIM:600076; AllianceGenome:HGNC:11973
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TNS; MXRA6; MST091; MST122; MST127; MSTP091; MSTP122; MSTP127; PPP1R155
    Summary
    The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
    Expression
    Broad expression in fat (RPKM 95.5), lung (RPKM 38.8) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    2q35
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (217799791..218033982, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (218283109..218495456, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (218664514..218867718, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene disrupted in renal carcinoma 3 Neighboring gene ATPase H+/K+ transporting non-gastric alpha2 subunit pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17106 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12308 Neighboring gene Sharpr-MPRA regulatory region 7557 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218661013-218661513 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17109 Neighboring gene RPL7L1 pseudogene 9 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:218678100-218679299 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218684858-218685358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218737749-218738250 Neighboring gene small nucleolar RNA, H/ACA box 115 Neighboring gene Sharpr-MPRA regulatory region 15318 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:218793628-218794497 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:218794829-218795372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218798027-218798526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218799196-218799704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218799705-218800214 Neighboring gene VISTA enhancer hs1764 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:218808487-218809332 Neighboring gene uncharacterized LOC124905960 Neighboring gene microRNA 6809 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218824713-218825227 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218828984-218829521 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218829522-218830058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218843426-218844314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218859337-218859836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218860238-218861016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218861017-218861794 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218866162-218866662 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218866663-218867163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17112 Neighboring gene uncharacterized LOC124907982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12309 Neighboring gene TNS1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:218890081-218890996 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:218896372-218896928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218899047-218899580 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218899581-218900113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218910221-218910722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218930441-218930983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218933725-218934588 Neighboring gene Sharpr-MPRA regulatory region 3825 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218940751-218941252 Neighboring gene RUN and FYVE domain containing 4 Neighboring gene C-X-C motif chemokine receptor 2 pseudogene 1 Neighboring gene C-X-C motif chemokine receptor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
    EBI GWAS Catalog
    Genome-wide association study identifies five loci associated with lung function.
    EBI GWAS Catalog
    Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
    EBI GWAS Catalog
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog
    Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC88584, DKFZp586K0617

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell-substrate junction assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fibroblast migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion HDA PubMed 
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tensin-1
    Names
    Matrix-remodelling-associated protein 6
    matrix-remodelling associated 6
    protein phosphatase 1, regulatory subunit 155

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308022.2NP_001294951.1  tensin-1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks in-frame exon in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AB209238, AC009469, AF225896, AK300345, AK309785, BC051304, BC116187, BC116188, BQ045472
      Consensus CDS
      CCDS77529.1
      UniProtKB/TrEMBL
      E9PF55, Q0VG55
      Related
      ENSP00000408724.1, ENST00000419504.6
      Conserved Domains (4) summary
      cd09927
      Location:14461560
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00404
      Location:77192
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      cd01213
      Location:15821715
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:179305
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    2. NM_001308023.2NP_001294952.1  tensin-1 isoform 3

      See identical proteins and their annotated locations for NP_001294952.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, and lacks two consecutive in-frame exons in the central coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC009469
      Consensus CDS
      CCDS77528.1
      UniProtKB/TrEMBL
      A0A087WWW7, E9PGF5, Q0VG54
      Related
      ENSP00000480559.2, ENST00000615025.6
      Conserved Domains (4) summary
      cd09927
      Location:14381553
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00404
      Location:77192
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      cd01213
      Location:15751708
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:179305
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    3. NM_001387777.1NP_001374706.1  tensin-1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC009469, AC010136
      Consensus CDS
      CCDS92941.1
      UniProtKB/Swiss-Prot
      A0A804HI61, Q4ZG71, Q6IPI5, Q9HBL0
      UniProtKB/TrEMBL
      A0A494C067
      Related
      ENSP00000506917.1, ENST00000682258.1
      Conserved Domains (6) summary
      cd09927
      Location:15631678
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:8971408
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:17001833
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      cd14560
      Location:139297
      PTP_tensin-1; protein tyrosine phosphatase-like domain of tensin-1
      pfam10409
      Location:304430
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cd20888
      Location:1672
      C1_TNS1_v; protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar proteins
    4. NM_022648.7NP_072174.3  tensin-1 isoform 1

      See identical proteins and their annotated locations for NP_072174.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AB209238, AC009469, AF225896, AL706926, BC051304, BC126910, BQ045472
      Consensus CDS
      CCDS2407.1
      UniProtKB/TrEMBL
      B2RU35
      Related
      ENSP00000171887.4, ENST00000171887.8
      Conserved Domains (5) summary
      cd09927
      Location:14591574
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00012
      Location:77192
      PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
      cd01213
      Location:15961729
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:179305
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl26464
      Location:555944
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      217799791..218033982 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047445637.1XP_047301593.1  tensin-1 isoform X2

    2. XM_047445644.1XP_047301600.1  tensin-1 isoform X12

      UniProtKB/TrEMBL
      A0A2R8Y4T1
      Related
      ENSP00000493967.1, ENST00000646520.1
    3. XM_047445639.1XP_047301595.1  tensin-1 isoform X6

    4. XM_047445638.1XP_047301594.1  tensin-1 isoform X3

    5. XM_047445636.1XP_047301592.1  tensin-1 isoform X1

    6. XM_047445645.1XP_047301601.1  tensin-1 isoform X13

    7. XM_047445642.1XP_047301598.1  tensin-1 isoform X10

    8. XM_047445640.1XP_047301596.1  tensin-1 isoform X8

    9. XM_024453079.2XP_024308847.1  tensin-1 isoform X5

      UniProtKB/TrEMBL
      A0A494C067
      Conserved Domains (5) summary
      cd09927
      Location:17291844
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:7521167
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:18661999
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      cd14560
      Location:139297
      PTP_tensin-1; protein tyrosine phosphatase-like domain of tensin-1
      cl00040
      Location:3467
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    10. XM_047445641.1XP_047301597.1  tensin-1 isoform X9

    11. XM_024453078.2XP_024308846.2  tensin-1 isoform X4

    12. XM_024453084.2XP_024308852.1  tensin-1 isoform X22

      UniProtKB/TrEMBL
      B2RU35
      Conserved Domains (5) summary
      cd09927
      Location:14591574
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00012
      Location:77192
      PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
      cd01213
      Location:15961729
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:179305
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl26464
      Location:555944
      Atrophin-1; Atrophin-1 family
    13. XM_047445646.1XP_047301602.1  tensin-1 isoform X14

    14. XM_024453081.2XP_024308849.1  tensin-1 isoform X11

      UniProtKB/TrEMBL
      A0A994J515
      Conserved Domains (5) summary
      cd09927
      Location:16041719
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00012
      Location:77192
      PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
      cd01213
      Location:17411874
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:179305
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl26464
      Location:6271042
      Atrophin-1; Atrophin-1 family
    15. XM_047445647.1XP_047301603.1  tensin-1 isoform X15

    16. XM_024453080.2XP_024308848.1  tensin-1 isoform X7

      UniProtKB/TrEMBL
      A0A994J515
      Conserved Domains (5) summary
      cd09927
      Location:16691784
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00404
      Location:142257
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      cd01213
      Location:18061939
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:244370
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl26464
      Location:6921107
      Atrophin-1; Atrophin-1 family
    17. XM_047445643.1XP_047301599.1  tensin-1 isoform X11

    18. XM_047445650.1XP_047301606.1  tensin-1 isoform X20

    19. XM_047445648.1XP_047301604.1  tensin-1 isoform X18

    20. XM_047445649.1XP_047301605.1  tensin-1 isoform X19

    21. XM_017004814.2XP_016860303.1  tensin-1 isoform X17

    22. XM_047445651.1XP_047301607.1  tensin-1 isoform X21

    23. XM_017004815.2XP_016860304.1  tensin-1 isoform X17

    24. XM_017004813.3XP_016860302.1  tensin-1 isoform X16

      UniProtKB/TrEMBL
      A0A994J515

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      218283109..218495456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343623.1XP_054199598.1  tensin-1 isoform X12

      UniProtKB/TrEMBL
      A0A2R8Y4T1
    2. XM_054343616.1XP_054199591.1  tensin-1 isoform X6

    3. XM_054343611.1XP_054199586.1  tensin-1 isoform X3

    4. XM_054343624.1XP_054199599.1  tensin-1 isoform X13

    5. XM_054343620.1XP_054199595.1  tensin-1 isoform X10

    6. XM_054343618.1XP_054199593.1  tensin-1 isoform X8

    7. XM_054343614.1XP_054199589.1  tensin-1 isoform X5

    8. XM_054343607.1XP_054199582.1  tensin-1 isoform X31

    9. XM_054343619.1XP_054199594.1  tensin-1 isoform X9

    10. XM_054343613.1XP_054199588.1  tensin-1 isoform X4

    11. XM_054343638.1XP_054199613.1  tensin-1 isoform X22

    12. XM_054343625.1XP_054199600.1  tensin-1 isoform X37

    13. XM_054343615.1XP_054199590.1  tensin-1 isoform X36

      UniProtKB/TrEMBL
      E9PF55
    14. XM_054343621.1XP_054199596.1  tensin-1 isoform X11

    15. XM_054343626.1XP_054199601.1  tensin-1 isoform X15

    16. XM_054343617.1XP_054199592.1  tensin-1 isoform X7

    17. XM_054343612.1XP_054199587.1  tensin-1 isoform X35

    18. XM_054343603.1XP_054199578.1  tensin-1 isoform X27

    19. XM_054343610.1XP_054199585.1  tensin-1 isoform X34

    20. XM_054343609.1XP_054199584.1  tensin-1 isoform X33

    21. XM_054343608.1XP_054199583.1  tensin-1 isoform X32

    22. XM_054343600.1XP_054199575.1  tensin-1 isoform X24

    23. XM_054343606.1XP_054199581.1  tensin-1 isoform X30

    24. XM_054343605.1XP_054199580.1  tensin-1 isoform X29

    25. XM_054343602.1XP_054199577.1  tensin-1 isoform X26

    26. XM_054343604.1XP_054199579.1  tensin-1 isoform X28

    27. XM_054343601.1XP_054199576.1  tensin-1 isoform X25

    28. XM_054343599.1XP_054199574.1  tensin-1 isoform X23

    29. XM_054343622.1XP_054199597.1  tensin-1 isoform X11

    30. XM_054343628.1XP_054199603.1  tensin-1 isoform X17

    31. XM_054343631.1XP_054199606.1  tensin-1 isoform X19

    32. XM_054343630.1XP_054199605.1  tensin-1 isoform X18

    33. XM_054343632.1XP_054199607.1  tensin-1 isoform X20

    34. XM_054343629.1XP_054199604.1  tensin-1 isoform X17

    35. XM_054343634.1XP_054199609.1  tensin-1 isoform X38

    36. XM_054343633.1XP_054199608.1  tensin-1 isoform X21

    37. XM_054343627.1XP_054199602.1  tensin-1 isoform X16

    38. XM_054343636.1XP_054199611.1  tensin-1 isoform X40

    39. XM_054343635.1XP_054199610.1  tensin-1 isoform X39

    40. XM_054343637.1XP_054199612.1  tensin-1 isoform X41

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_018274.2: Suppressed sequence

      Description
      NM_018274.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.