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    INP1 Inp1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855244, updated on 17-May-2024

    Summary

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    Gene symbol
    INP1
    Gene description
    Inp1p
    Primary source
    FungiDB:YMR204C
    Locus tag
    YMR204C
    See related
    SGD:S000004817; AllianceGenome:SGD:S000004817; VEuPathDB:YMR204C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein-macromolecule adaptor activity. Involved in peroxisome inheritance. Located in peroxisome. Is extrinsic component of intraperoxisomal membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See INP1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (670063..671325, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene C-8 sterol isomerase ERG2 Neighboring gene Tom40p Neighboring gene 6-phosphofructokinase subunit beta Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Peroxisome retention involves Inp1-dependent peroxisome-plasma membrane contact sites in yeast. Krikken AM, et al. J Cell Biol, 2020 Oct 5. PMID 32805027, Free PMC Article
    2. Characterization of survival and stress resistance in S. cerevisiae mutants affected in peroxisome inheritance and proliferation, Δinp1 and Δpex11. Scheckhuber CQ. Folia Microbiol (Praha), 2020 Apr. PMID 31273644
    3. An ER-peroxisome tether exerts peroxisome population control in yeast. Knoblach B, et al. EMBO J, 2013 Sep 11. PMID 23900285, Free PMC Article
    4. Yeast cells contain a heterogeneous population of peroxisomes that segregate asymmetrically during cell division. Choudhry SK, et al. J Cell Sci, 2018 Feb 7. PMID 29361529
    5. A dual function for Pex3p in peroxisome formation and inheritance. Munck JM, et al. J Cell Biol, 2009 Nov 16. PMID 19948495, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Pex3-Inp1 complex tethers yeast peroxisomes to the plasma membrane.
      Title: The Pex3-Inp1 complex tethers yeast peroxisomes to the plasma membrane.
    2. Peroxisome retention involves Inp1-dependent peroxisome-plasma membrane contact sites in yeast.
      Title: Peroxisome retention involves Inp1-dependent peroxisome-plasma membrane contact sites in yeast.
    3. Characterization of survival and stress resistance in S. cerevisiae mutants affected in peroxisome inheritance and proliferation, Deltainp1 and Deltapex11.
      Title: Characterization of survival and stress resistance in S. cerevisiae mutants affected in peroxisome inheritance and proliferation, Δinp1 and Δpex11.
    4. Inp1p acts as a molecular hinge between ER-bound Pex3p and peroxisomal Pex3p.
      Title: An ER-peroxisome tether exerts peroxisome population control in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peroxisome inheritance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peroxisome inheritance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extrinsic component of intraperoxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome HDA PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Inp1p
    NP_013931.1
    • Peripheral membrane protein of peroxisomes; involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane; Inp1p and Pex3p tether peroxisomes to plasma membrane

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      670063..671325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182711.1 → NP_013931.1  TPA: Inp1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013931.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZMR6, D6W029, Q03694
      UniProtKB/TrEMBL
      A0A8H4BWK0, B3LM92, B5VPX2, C8ZF69, G2WKR0, N1NYZ4
      Conserved Domains (1) summary
      pfam12634
      Location:79 → 260
      Inp1; Inheritance of peroxisomes protein 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03694.1

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