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    SYC1 cleavage polyadenylation factor subunit SYC1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854351, updated on 17-May-2024

    Summary

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    Gene symbol
    SYC1
    Gene description
    cleavage polyadenylation factor subunit SYC1
    Primary source
    FungiDB:YOR179C
    Locus tag
    YOR179C
    See related
    SGD:S000005705; AllianceGenome:SGD:S000005705; VEuPathDB:YOR179C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable RNA binding activity. Involved in negative regulation of mRNA 3'-end processing. Located in nucleus. Part of mRNA cleavage and polyadenylation specificity factor complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SYC1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (671845..672411, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Mpc54p Neighboring gene protein phosphatase regulator GAC1 Neighboring gene putative dodecenoyl-CoA isomerase DCI1 Neighboring gene actin-binding protein LAS17

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of the Brr5/Ysh1 C-terminal domain and its homolog Syc1 in mRNA 3'-end processing in Saccharomyces cerevisiae. Zhelkovsky A, et al. RNA, 2006 Mar. PMID 16431986, Free PMC Article
    2. The APT complex is involved in non-coding RNA transcription and is distinct from CPF. Lidschreiber M, et al. Nucleic Acids Res, 2018 Nov 30. PMID 30247719, Free PMC Article
    3. Architecture of eukaryotic mRNA 3'-end processing machinery. Casañal A, et al. Science, 2017 Nov 24. PMID 29074584, Free PMC Article
    4. Functional interactions between the transcription and mRNA 3' end processing machineries mediated by Ssu72 and Sub1. He X, et al. Genes Dev, 2003 Apr 15. PMID 12704082, Free PMC Article
    5. Ssu72 phosphatase-dependent erasure of phospho-Ser7 marks on the RNA polymerase II C-terminal domain is essential for viability and transcription termination. Zhang DW, et al. J Biol Chem, 2012 Mar 9. PMID 22235117, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Syc1 plays a more important role in snoRNA production.Syc1 is the defining subunit of a distinct APT complex, and is not part of CPF complex.
      Title: The APT complex is involved in non-coding RNA transcription and is distinct from CPF.
    2. Syc1, by mimicking the essential Brr5 C-terminus, serves as a negative regulator of mRNA 3'-end formation.
      Title: The role of the Brr5/Ysh1 C-terminal domain and its homolog Syc1 in mRNA 3'-end processing in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macromolecule biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of mRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mRNA cleavage and polyadenylation specificity factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cleavage polyadenylation factor subunit SYC1
    NP_014822.1
    • Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      671845..672411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183598.1 → NP_014822.1  TPA: cleavage polyadenylation factor subunit SYC1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014822.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2N5, Q08553
      UniProtKB/TrEMBL
      A0A8H4F8R0, B5VS64, C7GLR4, N1P3B5
      Conserved Domains (1) summary
      cl13209
      Location:28 → 186
      CPSF73-100_C; Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08553.1

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