U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Fignl1 fidgetin-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 60530, updated on 21-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Fignl1provided by MGI
    Official Full Name
    fidgetin-like 1provided by MGI
    Primary source
    MGI:MGI:1890648
    See related
    Ensembl:ENSMUSG00000035455 AllianceGenome:MGI:1890648
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable microtubule-severing ATPase activity. Involved in several processes, including male meiotic nuclear division; osteoblast differentiation; and osteoblast proliferation. Acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway. Located in nucleus and perinuclear region of cytoplasm. Is expressed in brain ventricular layer and inferior colliculus. Orthologous to human FIGNL1 (fidgetin like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver E14 (RPKM 22.0), liver E14.5 (RPKM 18.3) and 9 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    11 A1; 11 7.08 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (11737429..11758962, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (11800288..11808983, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:11557248-11557441 Neighboring gene predicted gene 11999 Neighboring gene STARR-positive B cell enhancer mm9_chr11:11590032-11590333 Neighboring gene IKAROS family zinc finger 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:11611793-11612034 Neighboring gene predicted gene 12000 Neighboring gene STARR-positive B cell enhancer ABC_E5207 Neighboring gene STARR-positive B cell enhancer ABC_E3931 Neighboring gene STARR-positive B cell enhancer mm9_chr11:11666148-11666448 Neighboring gene STARR-positive B cell enhancer ABC_E6952 Neighboring gene STARR-seq mESC enhancer starr_28598 Neighboring gene STARR-seq mESC enhancer starr_28601 Neighboring gene STARR-seq mESC enhancer starr_28602 Neighboring gene dopa decarboxylase Neighboring gene predicted gene, 51937 Neighboring gene RIKEN cDNA 1700042O10 gene Neighboring gene STARR-seq mESC enhancer starr_28608

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Microtubule-severing protein Fidgetin-like 1 promotes spindle organization during meiosis of mouse oocytes. Shou HF, et al. Zygote, 2022 Dec. PMID 36148793
    2. mRNA expression analysis of cell cycle genes in islets of pregnant mice. Schraenen A, et al. Diabetologia, 2010 Dec. PMID 20886204, Free PMC Article
    3. Fidgetin-like 1 gene inhibited by basic fibroblast growth factor regulates the proliferation and differentiation of osteoblasts. Park SJ, et al. J Bone Miner Res, 2007 Jun. PMID 17352653
    4. Fidgetin-like1 is a strong candidate for a dynamic impairment of male meiosis leading to reduced testis weight in mice. L'Hôte D, et al. PLoS One, 2011. PMID 22110678, Free PMC Article
    5. Paternal deletion of Meg1/Grb10 DMR causes maternalization of the Meg1/Grb10 cluster in mouse proximal Chromosome 11 leading to severe pre- and postnatal growth retardation. Shiura H, et al. Hum Mol Genet, 2009 Apr 15. PMID 19174477

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination.
      Title: FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination.
    2. The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart.
      Title: The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart.
    3. Microtubule-severing protein Fidgetin-like 1 promotes spindle organization during meiosis of mouse oocytes.
      Title: Microtubule-severing protein Fidgetin-like 1 promotes spindle organization during meiosis of mouse oocytes.
    4. Fignl1 as a novel actor in mammal's male meiosis dynamics
      Title: Fidgetin-like1 is a strong candidate for a dynamic impairment of male meiosis leading to reduced testis weight in mice.
    5. FIGNL1, a subfamily member of the AAA family of proteins, might play some regulatory role in osteoblast proliferation and differentiation.
      Title: Fidgetin-like 1 gene inhibited by basic fibroblast growth factor regulates the proliferation and differentiation of osteoblasts.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule severing ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in osteoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    fidgetin-like protein 1
    NP_001156831.1
    NP_001156832.1
    NP_001412580.1
    NP_001412581.1
    NP_001412582.1
    NP_001412583.1
    NP_001412584.1
    NP_001412585.1
    NP_001412586.1
    NP_001412587.1
    NP_001412588.1
    NP_068691.2
    XP_036012780.1
    XP_036012781.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163359.2 → NP_001156831.1  fidgetin-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001156831.1

      Status: VALIDATED

      Source sequence(s)
      AL596450
      Consensus CDS
      CCDS24438.1
      UniProtKB/Swiss-Prot
      Q3UF48, Q8BPY9, Q8C2I6, Q9ERZ5
      Related
      ENSMUSP00000126340.2, ENSMUST00000171938.2
      Conserved Domains (3) summary
      pfam09336
      Location:640 → 680
      Vps4_C; Vps4 C terminal oligomerization domain
      pfam17862
      Location:599 → 630
      AAA_lid_3; AAA+ lid domain
      cd19525
      Location:389 → 574
      RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)

    2. NM_001163360.1 → NP_001156832.1  fidgetin-like protein 1

      See identical proteins and their annotated locations for NP_001156832.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK051874, AK143850, BY231020, CN693395
      Consensus CDS
      CCDS24438.1
      UniProtKB/Swiss-Prot
      Q3UF48, Q8BPY9, Q8C2I6, Q9ERZ5
      Related
      ENSMUSP00000127489.2, ENSMUST00000171080.8
      Conserved Domains (3) summary
      pfam09336
      Location:640 → 680
      Vps4_C; Vps4 C terminal oligomerization domain
      pfam17862
      Location:599 → 630
      AAA_lid_3; AAA+ lid domain
      cd19525
      Location:389 → 574
      RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)

    3. NM_001425651.1 → NP_001412580.1  fidgetin-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL596450

    4. NM_001425652.1 → NP_001412581.1  fidgetin-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL596450

    5. NM_001425653.1 → NP_001412582.1  fidgetin-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596450
      UniProtKB/Swiss-Prot
      Q3UF48, Q8BPY9, Q8C2I6, Q9ERZ5

    6. NM_001425654.1 → NP_001412583.1  fidgetin-like protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL596450

    7. NM_001425655.1 → NP_001412584.1  fidgetin-like protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL596450

    8. NM_001425656.1 → NP_001412585.1  fidgetin-like protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL596450

    9. NM_001425657.1 → NP_001412586.1  fidgetin-like protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL596450

    10. NM_001425658.1 → NP_001412587.1  fidgetin-like protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL596450

    11. NM_001425659.1 → NP_001412588.1  fidgetin-like protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL596450

    12. NM_021891.4 → NP_068691.2  fidgetin-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_068691.2

      Status: VALIDATED

      Source sequence(s)
      AL596450
      Consensus CDS
      CCDS24438.1
      UniProtKB/Swiss-Prot
      Q3UF48, Q8BPY9, Q8C2I6, Q9ERZ5
      Related
      ENSMUSP00000036932.5, ENSMUST00000047689.11
      Conserved Domains (3) summary
      pfam09336
      Location:640 → 680
      Vps4_C; Vps4 C terminal oligomerization domain
      pfam17862
      Location:599 → 630
      AAA_lid_3; AAA+ lid domain
      cd19525
      Location:389 → 574
      RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)

    RNA

    1. NR_189574.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL596450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      11737429..11758962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156888.1 → XP_036012781.1  fidgetin-like protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q3UF48, Q8BPY9, Q8C2I6, Q9ERZ5
      Conserved Domains (3) summary
      pfam09336
      Location:640 → 680
      Vps4_C; Vps4 C terminal oligomerization domain
      pfam17862
      Location:599 → 630
      AAA_lid_3; AAA+ lid domain
      cd19525
      Location:389 → 574
      RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)

    2. XM_036156887.1 → XP_036012780.1  fidgetin-like protein 1 isoform X1

      Conserved Domains (3) summary
      pfam09336
      Location:649 → 689
      Vps4_C; Vps4 C terminal oligomerization domain
      pfam17862
      Location:608 → 639
      AAA_lid_3; AAA+ lid domain
      cd19525
      Location:398 → 583
      RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BPY9.1 GenPept UniProtKB/Swiss-Prot:Q8BPY9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous