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    Naa20 N(alpha)-acetyltransferase 20, NatB catalytic subunit [ Mus musculus (house mouse) ]

    Gene ID: 67877, updated on 14-May-2024

    Summary

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    Official Symbol
    Naa20provided by MGI
    Official Full Name
    N(alpha)-acetyltransferase 20, NatB catalytic subunitprovided by MGI
    Primary source
    MGI:MGI:1915127
    See related
    Ensembl:ENSMUSG00000002728 AllianceGenome:MGI:1915127
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nat5; D2Ertd186e; 1500004D14Rik; 2900026I01Rik
    Summary
    Predicted to enable peptide alpha-N-acetyltransferase activity. Predicted to be involved in N-terminal peptidyl-methionine acetylation. Predicted to be located in cytosol and nucleus. Predicted to be part of NatB complex. Is expressed in several structures, including alimentary system; brain; heart; retina; and skin. Orthologous to human NAA20 (N-alpha-acetyltransferase 20, NatB catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 9.7), placenta adult (RPKM 9.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 G1; 2 71.28 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (145743454..145758345)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (145901539..145916425)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Ras and Rab interactor 2 Neighboring gene STARR-seq mESC enhancer starr_05932 Neighboring gene predicted gene, 54121 Neighboring gene STARR-seq mESC enhancer starr_05933 Neighboring gene STARR-positive B cell enhancer ABC_E8796 Neighboring gene predicted gene, 39954 Neighboring gene TM2 domain containing 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5996 Neighboring gene crooked neck pre-mRNA splicing factor 1 Neighboring gene STARR-positive B cell enhancer mm9_chr2:145783203-145783504 Neighboring gene STARR-seq mESC enhancer starr_05934 Neighboring gene cilia and flagella associated protein 61 Neighboring gene STARR-seq mESC enhancer starr_05935 Neighboring gene predicted gene, 34629

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NatB Catalytic Subunit Depletion Disrupts DNA Replication Initiation Leading to Senescence in MEFs. Elurbide J, et al. Int J Mol Sci, 2023 May 13. PMID 37240070, Free PMC Article
    2. Implication of human N-alpha-acetyltransferase 5 in cellular proliferation and carcinogenesis. Ametzazurra A, et al. Oncogene, 2008 Dec 11. PMID 18794801
    3. ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway. Kuo HP, et al. Sci Signal, 2010 Feb 9. PMID 20145209, Free PMC Article
    4. Cloning and characterization of hNAT5/hSAN: an evolutionarily conserved component of the NatA protein N-alpha-acetyltransferase complex. Arnesen T, et al. Gene, 2006 Apr 26. PMID 16507339
    5. Spatio-temporal expression pattern of the NatB complex, Nat5/Mdm20 in the developing mouse brain: implications for co-operative versus non-co-operative actions of Mdm20 and Nat5. Ohyama K, et al. Gene Expr Patterns, 2012 Jan-Feb. PMID 22101279

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NAA20 recruits Rin2 and promotes triple-negative breast cancer progression by regulating Rab5A-mediated activation of EGFR signaling.
      Title: NAA20 recruits Rin2 and promotes triple-negative breast cancer progression by regulating Rab5A-mediated activation of EGFR signaling.
    2. Mdm20 is not necessarily co-expressed with Nat5 in the developing mouse brain.
      Title: Spatio-temporal expression pattern of the NatB complex, Nat5/Mdm20 in the developing mouse brain: implications for co-operative versus non-co-operative actions of Mdm20 and Nat5.
    3. ARD1 functions as an inhibitor of the mTOR pathway and that dysregulation of the ARD1-TSC2-mTOR axis may contribute to cancer development
      Title: ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144325

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-aspartic acid acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-terminal peptidyl-glutamic acid acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-terminal peptidyl-glutamine acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-terminal peptidyl-methionine acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-terminal protein amino acid acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of NatB complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatB complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    N-alpha-acetyltransferase 20
    Names
    N-acetyltransferase 5 (ARD1 homolog, S. cerevisiae)
    N-terminal acetyltransferase B complex catalytic subunit NAA20
    N-terminal acetyltransferase B complex catalytic subunit NAT5
    methionine N-acetyltransferase
    natB catalytic subunit
    natB complex subunit NAT5
    NP_001135437.1
    NP_080701.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001141965.1 → NP_001135437.1  N-alpha-acetyltransferase 20 isoform 1

      See identical proteins and their annotated locations for NP_001135437.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
      Source sequence(s)
      AK005143, AK009229, CO802916
      Consensus CDS
      CCDS50735.1
      UniProtKB/Swiss-Prot
      P61600, Q14B28, Q4VAC3
      Related
      ENSMUSP00000105627.2, ENSMUST00000110000.8
      Conserved Domains (1) summary
      COG0456
      Location:1 → 156
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

    2. NM_026425.3 → NP_080701.1  N-alpha-acetyltransferase 20 isoform 2

      See identical proteins and their annotated locations for NP_080701.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an in-frame alternate splice site in the coding region, compared to variant 1, and encodes a longer protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK005143, AK009229, CO802916
      Consensus CDS
      CCDS16827.1
      UniProtKB/TrEMBL
      Q9DB82
      Related
      ENSMUSP00000002805.8, ENSMUST00000002805.14
      Conserved Domains (1) summary
      COG0456
      Location:1 → 166
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      145743454..145758345
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003953700.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61600.1 GenPept UniProtKB/Swiss-Prot:P61600

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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