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    Sf3a3 splicing factor 3a, subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 75062, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Sf3a3provided by MGI
    Official Full Name
    splicing factor 3a, subunit 3provided by MGI
    Primary source
    MGI:MGI:1922312
    See related
    Ensembl:ENSMUSG00000028902 AllianceGenome:MGI:1922312
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    60kDa; 4930512K19Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in U2-type prespliceosome assembly. Predicted to act upstream of or within RNA splicing. Part of U2 snRNP. Is expressed in central nervous system and sensory organ. Orthologous to human SF3A3 (splicing factor 3a subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 56.6), liver E14 (RPKM 31.1) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D2.2; 4 57.88 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (124602966..124626234)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (124714861..124732423)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene UTP11 small subunit processome component Neighboring gene STARR-positive B cell enhancer ABC_E6213 Neighboring gene STARR-seq mESC enhancer starr_11340 Neighboring gene four and a half LIM domains 3 Neighboring gene STARR-positive B cell enhancer ABC_E6214 Neighboring gene PRELI domain containing 1 pseudogene Neighboring gene microRNA 697 Neighboring gene predicted gene 12915 Neighboring gene predicted gene, 32117 Neighboring gene inositol polyphosphate-5-phosphatase B Neighboring gene microRNA 698

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Temporal and tissue specific regulation of RP-associated splicing factor genes PRPF3, PRPF31 and PRPC8--implications in the pathogenesis of RP. Cao H, et al. PLoS One, 2011 Jan 19. PMID 21283520, Free PMC Article
    2. STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells. Jin L, et al. Nat Commun, 2020 Nov 23. PMID 33230114, Free PMC Article
    3. Systematic identification of factors for provirus silencing in embryonic stem cells. Yang BX, et al. Cell, 2015 Sep 24. PMID 26365490, Free PMC Article
    4. Oct4 links multiple epigenetic pathways to the pluripotency network. Ding J, et al. Cell Res, 2012 Jan. PMID 22083510, Free PMC Article
    5. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC103282

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in U2-type prespliceosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of U2 snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    splicing factor 3A subunit 3
    Names
    SAP 61
    SF3a60
    spliceosome-associated protein 61

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029157.4 → NP_083433.1  splicing factor 3A subunit 3

      See identical proteins and their annotated locations for NP_083433.1

      Status: VALIDATED

      Source sequence(s)
      AL606907
      Consensus CDS
      CCDS38875.1
      UniProtKB/Swiss-Prot
      Q9D554
      UniProtKB/TrEMBL
      Q58E59
      Related
      ENSMUSP00000030734.5, ENSMUST00000030734.5
      Conserved Domains (2) summary
      COG5188
      Location:2 → 501
      PRP9; Splicing factor 3a, subunit 3 [RNA processing and modification]
      pfam11931
      Location:323 → 500
      DUF3449; Domain of unknown function (DUF3449)

    RNA

    1. NR_185053.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL606907

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      124602966..124626234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164510.1 → XP_036020403.1  splicing factor 3A subunit 3 isoform X1

      UniProtKB/Swiss-Prot
      Q9D554
      UniProtKB/TrEMBL
      Q58E59
      Conserved Domains (2) summary
      COG5188
      Location:2 → 501
      PRP9; Splicing factor 3a, subunit 3 [RNA processing and modification]
      pfam11931
      Location:323 → 500
      DUF3449; Domain of unknown function (DUF3449)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D554.2 GenPept UniProtKB/Swiss-Prot:Q9D554

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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