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    Otub2 OTU domain, ubiquitin aldehyde binding 2 [ Mus musculus (house mouse) ]

    Gene ID: 68149, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Otub2provided by MGI
    Official Full Name
    OTU domain, ubiquitin aldehyde binding 2provided by MGI
    Primary source
    MGI:MGI:1915399
    See related
    Ensembl:ENSMUSG00000021203 AllianceGenome:MGI:1915399
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OTB2; OTU2; 2010015L18Rik; 4930586I02Rik
    Summary
    Predicted to enable thiol-dependent deubiquitinase and ubiquitin binding activity. Predicted to be involved in negative regulation of nitrogen compound metabolic process and protein deubiquitination. Predicted to act upstream of or within proteolysis. Predicted to be active in nucleus. Orthologous to human OTUB2 (OTU deubiquitinase, ubiquitin aldehyde binding 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 80.7), liver E14 (RPKM 6.9) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 E; 12 52.92 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (103343244..103372609)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (103376894..103406350)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 181, member A Neighboring gene predicted gene 29508 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:104569739-104569961 Neighboring gene ankyrin repeat and SOCS box-containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E4038 Neighboring gene STARR-positive B cell enhancer ABC_E1863 Neighboring gene predicted gene 15523 Neighboring gene STARR-positive B cell enhancer ABC_E7174 Neighboring gene DEAD box helicase 24 Neighboring gene STARR-positive B cell enhancer ABC_E4039 Neighboring gene predicted gene, 53758

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis. Chang W, et al. Cell Rep, 2022 Oct 25. PMID 36288705
    2. Otubain 2 is a novel promoter of beta cell survival as revealed by siRNA high-throughput screens of human pancreatic islets. Beck A, et al. Diabetologia, 2013 Jun. PMID 23515685
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. siRNAs of OTUB2 impaired insulin secretion both under basal conditions and in cytokine-treated MIN6 cells
      Title: Otubain 2 is a novel promoter of beta cell survival as revealed by siRNA high-throughput screens of human pancreatic islets.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin thioesterase OTUB2
    Names
    OTU domain-containing ubiquitin aldehyde-binding protein 2
    deubiquitinating enzyme OTUB2
    otubain-2
    ubiquitin-specific-processing protease OTUB2
    NP_001171312.1
    NP_080856.1
    XP_006516248.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177841.2 → NP_001171312.1  ubiquitin thioesterase OTUB2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC154347, AC160131
      Consensus CDS
      CCDS49150.1
      UniProtKB/TrEMBL
      D3Z0Y8
      Related
      ENSMUSP00000098655.3, ENSMUST00000101094.9
      Conserved Domains (1) summary
      pfam10275
      Location:90 → 318
      Peptidase_C65; Peptidase C65 Otubain

    2. NM_026580.5 → NP_080856.1  ubiquitin thioesterase OTUB2 isoform 2

      See identical proteins and their annotated locations for NP_080856.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon in the 5' region, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC154347, AC160131
      Consensus CDS
      CCDS36528.1
      UniProtKB/Swiss-Prot
      Q3TUZ2, Q9CQX0, Q9D4K8
      Related
      ENSMUSP00000021620.7, ENSMUST00000021620.13
      Conserved Domains (1) summary
      pfam10275
      Location:1 → 229
      Peptidase_C65; Peptidase C65 Otubain

    RNA

    1. NR_033587.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter and lacks 5' coding exons compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of any downstream ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC154347, AC160131

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      103343244..103372609
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516185.5 → XP_006516248.3  ubiquitin thioesterase OTUB2 isoform X1

      Conserved Domains (1) summary
      pfam10275
      Location:65 → 292
      Peptidase_C65; Peptidase C65 Otubain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQX0.1 GenPept UniProtKB/Swiss-Prot:Q9CQX0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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