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    Haghl hydroxyacylglutathione hydrolase-like [ Mus musculus (house mouse) ]

    Gene ID: 68977, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Haghlprovided by MGI
    Official Full Name
    hydroxyacylglutathione hydrolase-likeprovided by MGI
    Primary source
    MGI:MGI:1919877
    See related
    Ensembl:ENSMUSG00000061046 AllianceGenome:MGI:1919877
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500017E18Rik; 2810014I23Rik; C330022E15Rik
    Summary
    Predicted to enable hydroxyacylglutathione hydrolase activity. Predicted to be involved in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione. Is expressed in several structures, including eye; forelimb bud; nervous system; and respiratory system. Orthologous to human HAGHL (hydroxyacylglutathione hydrolase like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 50.2), CNS E14 (RPKM 37.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 A3.3; 17 12.88 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25998817..26004560, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25779843..25785586, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene mesothelin Neighboring gene STARR-seq mESC enhancer starr_42110 Neighboring gene predicted gene, 41550 Neighboring gene STARR-positive B cell enhancer ABC_E3191 Neighboring gene cytosolic iron-sulfur assembly component 3 Neighboring gene microRNA 6966 Neighboring gene STARR-positive B cell enhancer ABC_E5579 Neighboring gene coiled-coil domain containing 78 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:25929287-25929470 Neighboring gene adenine nucleotide translocase lysine methyltransferase Neighboring gene meteorin, glial cell differentiation regulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
    2. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
    3. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC101974

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxyacylglutathione hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    hydroxyacylglutathione hydrolase-like protein
    NP_001258362.1
    NP_001258363.1
    NP_001258364.1
    NP_001258365.1
    NP_001258366.1
    NP_001365709.1
    NP_001365710.1
    NP_001365711.1
    NP_001365712.1
    NP_001365713.1
    NP_081173.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271433.1 → NP_001258362.1  hydroxyacylglutathione hydrolase-like protein isoform a

      See identical proteins and their annotated locations for NP_001258362.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AI844861, BC083322, BY265614
      Consensus CDS
      CCDS28527.1
      UniProtKB/Swiss-Prot
      Q8C8C4, Q9DB32
      Related
      ENSMUSP00000077091.4, ENSMUST00000077938.10
      Conserved Domains (3) summary
      PLN02469
      Location:1 → 245
      PLN02469; hydroxyacylglutathione hydrolase
      pfam16123
      Location:174 → 252
      HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
      cd07723
      Location:4 → 173
      hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain

    2. NM_001271434.1 → NP_001258363.1  hydroxyacylglutathione hydrolase-like protein isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AI844861, AK012748, BY265614
      Related
      ENSMUST00000137587.8
      Conserved Domains (2) summary
      pfam16123
      Location:174 → 201
      HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
      cd07723
      Location:4 → 173
      hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain

    3. NM_001271435.1 → NP_001258364.1  hydroxyacylglutathione hydrolase-like protein isoform c

      See identical proteins and their annotated locations for NP_001258364.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate 3' UTR and 3' coding region compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK047517, BY265614
      Consensus CDS
      CCDS70773.1
      UniProtKB/Swiss-Prot
      Q9DB32
      Related
      ENSMUSP00000116841.2, ENSMUST00000140738.8
      Conserved Domains (3) summary
      COG0491
      Location:1 → 226
      GloB; Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II [General function prediction only]
      pfam16123
      Location:174 → 229
      HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
      cd07723
      Location:4 → 173
      hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain

    4. NM_001271436.1 → NP_001258365.1  hydroxyacylglutathione hydrolase-like protein isoform d

      See identical proteins and their annotated locations for NP_001258365.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Variants 5 and 6 encode the same isoform (d).
      Source sequence(s)
      AI844861, AK012748, AK021220, BY265614
      Consensus CDS
      CCDS70772.1
      UniProtKB/TrEMBL
      D3YZU6
      Related
      ENSMUSP00000120885.2, ENSMUST00000133071.8
      Conserved Domains (2) summary
      pfam16123
      Location:126 → 204
      HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
      cd07723
      Location:1 → 125
      hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain

    5. NM_001271437.1 → NP_001258366.1  hydroxyacylglutathione hydrolase-like protein isoform d

      See identical proteins and their annotated locations for NP_001258366.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks a portion of the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Variants 5 and 6 encode the same isoform (d).
      Source sequence(s)
      AI844861, AK012748, AK021220, BY265614
      Consensus CDS
      CCDS70772.1
      UniProtKB/TrEMBL
      D3YZU6
      Related
      ENSMUSP00000115538.2, ENSMUST00000138759.8
      Conserved Domains (2) summary
      pfam16123
      Location:126 → 204
      HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
      cd07723
      Location:1 → 125
      hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain

    6. NM_001378780.1 → NP_001365709.1  hydroxyacylglutathione hydrolase-like protein isoform f

      Status: VALIDATED

      Source sequence(s)
      AC134908
      Conserved Domains (1) summary
      PLN02469
      Location:1 → 272
      PLN02469; hydroxyacylglutathione hydrolase

    7. NM_001378781.1 → NP_001365710.1  hydroxyacylglutathione hydrolase-like protein isoform e

      Status: VALIDATED

      Source sequence(s)
      AC134908
      Related
      ENSMUST00000129917.8
      Conserved Domains (1) summary
      PLN02469
      Location:1 → 254
      PLN02469; hydroxyacylglutathione hydrolase

    8. NM_001378782.1 → NP_001365711.1  hydroxyacylglutathione hydrolase-like protein isoform g

      Status: VALIDATED

      Source sequence(s)
      AC134908
      Conserved Domains (1) summary
      PLN02469
      Location:1 → 227
      PLN02469; hydroxyacylglutathione hydrolase

    9. NM_001378783.1 → NP_001365712.1  hydroxyacylglutathione hydrolase-like protein isoform h

      Status: VALIDATED

      Source sequence(s)
      AC134908
      Conserved Domains (1) summary
      PLN02469
      Location:1 → 179
      PLN02469; hydroxyacylglutathione hydrolase

    10. NM_001378784.1 → NP_001365713.1  hydroxyacylglutathione hydrolase-like protein isoform h

      Status: VALIDATED

      Source sequence(s)
      AC134908
      Conserved Domains (1) summary
      PLN02469
      Location:1 → 179
      PLN02469; hydroxyacylglutathione hydrolase

    11. NM_026897.3 → NP_081173.1  hydroxyacylglutathione hydrolase-like protein isoform a

      See identical proteins and their annotated locations for NP_081173.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AI844861, AK005274, BY293803
      Consensus CDS
      CCDS28527.1
      UniProtKB/Swiss-Prot
      Q8C8C4, Q9DB32
      Related
      ENSMUSP00000119647.2, ENSMUST00000150324.8
      Conserved Domains (3) summary
      PLN02469
      Location:1 → 245
      PLN02469; hydroxyacylglutathione hydrolase
      pfam16123
      Location:174 → 252
      HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
      cd07723
      Location:4 → 173
      hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25998817..26004560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DB32.1 GenPept UniProtKB/Swiss-Prot:Q9DB32

    Gene LinkOut

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