Fut7 fucosyltransferase 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fut7provided by RGD
Official Full Name: fucosyltransferase 7provided by RGD
Primary source: RGD:735019
See related: Ensembl:ENSRNOG00000014156 AllianceGenome:RGD:735019
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fuc-TVII; FucT-VII
Summary: Enables alpha-(1->3)-fucosyltransferase activity. Involved in inflammatory response. Predicted to be located in trans-Golgi network. Orthologous to human FUT7 (fucosyltransferase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 10.6), Thymus (RPKM 8.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p13

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (28635913..28640407)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (8237687..8242273)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (2637281..2646497)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables alpha-(1->3)-fucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-(1->3)-fucosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables alpha-(1->3)-fucosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables alpha-(1->3)-fucosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables fucosyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell migration	ISO Inferred from Sequence Orthology more info
involved_in ceramide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in embryo implantation	ISO Inferred from Sequence Orthology more info
involved_in fucosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leukocyte migration involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in leukocyte migration involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in leukocyte migration involved in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in lymphocyte migration into lymph node	ISO Inferred from Sequence Orthology more info
involved_in lymphocyte migration into lymph node	ISS Inferred from Sequence or Structural Similarity more info
involved_in lymphocyte migration into lymphoid organs	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte tethering or rolling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neutrophil migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in protein glycosylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion molecule production	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of leukocyte adhesion to vascular endothelial cell	ISO Inferred from Sequence Orthology more info
involved_in regulation of leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in regulation of neutrophil extravasation	ISO Inferred from Sequence Orthology more info
involved_in regulation of type IV hypersensitivity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-(1,3)-fucosyltransferase 7

Names: alpha (1,3) fucosyltransferase; fucosyltransferase VII; galactoside 3-L-fucosyltransferase; selectin ligand synthase

NP_955785.1

EC 2.4.1.-

XP_006233647.1

EC 2.4.1.-

XP_006233648.1

EC 2.4.1.-

XP_006233649.1

EC 2.4.1.-

XP_038960642.1

EC 2.4.1.-

XP_038960643.1

EC 2.4.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199491.2 → NP_955785.1 alpha-(1,3)-fucosyltransferase 7

See identical proteins and their annotated locations for NP_955785.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q712G6

Related

ENSRNOP00000033858.4, ENSRNOT00000037169.5

Conserved Domains (2) summary

pfam00852
Location:197 → 365

Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

pfam17039
Location:72 → 182

Glyco_tran_10_N; Fucosyltransferase, N-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

28635913..28640407

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006233587.5 → XP_006233649.1 alpha-(1,3)-fucosyltransferase 7 isoform X5

See identical proteins and their annotated locations for XP_006233649.1

Conserved Domains (2) summary

pfam00852
Location:145 → 313

Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

pfam17039
Location:20 → 130

Glyco_tran_10_N; Fucosyltransferase, N-terminal
XM_006233585.5 → XP_006233647.1 alpha-(1,3)-fucosyltransferase 7 isoform X1

Conserved Domains (2) summary

pfam00852
Location:207 → 375

Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

pfam17039
Location:82 → 192

Glyco_tran_10_N; Fucosyltransferase, N-terminal
XM_006233586.5 → XP_006233648.1 alpha-(1,3)-fucosyltransferase 7 isoform X2

Conserved Domains (2) summary

pfam00852
Location:180 → 348

Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

pfam17039
Location:55 → 165

Glyco_tran_10_N; Fucosyltransferase, N-terminal
XM_039104715.2 → XP_038960643.1 alpha-(1,3)-fucosyltransferase 7 isoform X4

Conserved Domains (2) summary

pfam00852
Location:168 → 336

Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

pfam17039
Location:43 → 153

Glyco_tran_10_N; Fucosyltransferase, N-terminal
XM_039104714.2 → XP_038960642.1 alpha-(1,3)-fucosyltransferase 7 isoform X3

UniProtKB/TrEMBL

A6JT59

Conserved Domains (2) summary

pfam00852
Location:169 → 337

Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

pfam17039
Location:44 → 154

Glyco_tran_10_N; Fucosyltransferase, N-terminal