Nudt16 nudix hydrolase 16 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nudt16provided by RGD
Official Full Name: nudix hydrolase 16provided by RGD
Primary source: RGD:1311387
See related: Ensembl:ENSRNOG00000012962 AllianceGenome:RGD:1311387
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311387
Summary: Predicted to enable several functions, including metal ion binding activity; purine ribonucleoside triphosphate binding activity; and pyrophosphatase activity. Predicted to be involved in IDP catabolic process; RNA metabolic process; and positive regulation of cell cycle process. Predicted to act upstream of or within chromosome organization and dITP catabolic process. Predicted to be located in cytoplasm; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human NUDT16 (nudix hydrolase 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 65.3), Kidney (RPKM 54.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (114618706..114620761, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (105739927..105741982, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (113673069..113675124, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity	ISO Inferred from Sequence Orthology more info
enables IDP phosphatase activity	ISO Inferred from Sequence Orthology more info
enables chloride ion binding	ISO Inferred from Sequence Orthology more info
enables cobalt ion binding	ISO Inferred from Sequence Orthology more info
enables dIDP phosphatase activity	ISO Inferred from Sequence Orthology more info
enables dITP diphosphatase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables metalloexopeptidase activity	ISO Inferred from Sequence Orthology more info
enables phosphodiesterase decapping endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphodiesterase decapping endonuclease activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables snoRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables snoRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in NAD-cap decapping	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chromosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dITP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell cycle process	ISO Inferred from Sequence Orthology more info
involved_in sno(s)RNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sno(s)RNA catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: U8 snoRNA-decapping enzyme

Names: nudix (nucleoside diphosphate linked moiety X)-type motif 16

NP_001121026.1

EC 3.6.1.62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127554.1 → NP_001121026.1 U8 snoRNA-decapping enzyme

See identical proteins and their annotated locations for NP_001121026.1

Status: PROVISIONAL

Source sequence(s)

BC166915

UniProtKB/TrEMBL

A6I2M6, B2RYV2, G3V7P6

Related

ENSRNOP00000017318.4, ENSRNOT00000017318.6

Conserved Domains (1) summary

cd02883
Location:45 → 111

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...