Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Cyp4a2provided by RGD
Full Name: cytochrome P450, family 4, subfamily a, polypeptide 2provided by RGD
Primary source: RGD:2479
See related: Ensembl:ENSRNOG00000066487 AllianceGenome:RGD:2479
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cyp4a11
Summary: Enables alkane 1-monooxygenase activity; arachidonic acid binding activity; and arachidonic acid monooxygenase activity. Involved in several processes, including fatty acid metabolic process; icosanoid biosynthetic process; and response to hormone. Located in intracellular membrane-bounded organelle. Biomarker of autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human CYP4A11 (cytochrome P450 family 4 subfamily A member 11) and CYP4A22 (cytochrome P450 family 4 subfamily A member 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 5968.9) and Liver (RPKM 2516.7) See more
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Genomic context

Location:: 5q35

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (134160356..134170908, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (128922355..128934188, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (134196910..134207888, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

dihydrotestosterone decreased omega-hydroxylase activity in ) female rats (by 50%) but significantly increased omega-hydroxylase activity in CYP4A2(-/-) female rats
Title: 20-HETE and CYP4A2 ω-hydroxylase contribute to the elevated blood pressure in hyperandrogenemic female rats.
Here we report that cultured astrocytes express CYP 4A2/3 omega-hydroxylase mRNA and CYP 4A protein and produce 20-HETE and the CYP epoxygenase metabolites epoxyeicosatrienoic acids (EETs) when incubated with AA
Title: Expression of CYP 4A ω-hydroxylase and formation of 20-hydroxyeicosatetreanoic acid (20-HETE) in cultured rat brain astrocytes.
Augmentation of vascular endothelial 20-HETE levels by CYP4A2 overexpression results in hypertension, endothelial dysfunction, and renal injury.
Title: Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE.
Intravenous injection of adenovirus transfected-CYP4A2 increased blood pressure and hypertension.
Title: Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus.
NO differentially regulates the function of CYP4A1, -4A2, and -4A3 isoforms in the renal vasculature and the nephron.
Title: Contribution of cytochrome P450 4A isoforms to renal functional response to inhibition of nitric oxide production in the rat.
analysis of specific pattern of cyp4A isoform expression in skeletal muscle microcirculation reveals that Cyp4a1 and CYP4A2 mRNA were not expressed in arterioles and skeletal muscle cells, although all four isoforms were strongly expressed in the liver
Title: Expression of cytochrome P450-4A isoforms in the rat cremaster muscle microcirculation.

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General gene information

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Markers

RH141571 (e-PCR)
- UniSTS:223565

RH131600 (e-PCR)
- UniSTS:214883

D5Wox12 (e-PCR)
- UniSTS:118123

Cyp4a14 (e-PCR), detects polymorphism
- UniSTS:463007

D5Mcw1 (e-PCR)
- UniSTS:240078

D5Wox2 (e-PCR)
- UniSTS:117982

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alkane 1-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alkane 1-monooxygenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables arachidonic acid 11,12-epoxygenase activity	TAS Traceable Author Statement more info	PubMed
enables arachidonic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables arachidonic acid monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arachidonic acid monooxygenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables fatty acid binding	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid omega-hydroxylase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in arachidonic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in arachidonic acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in arachidonic acid metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in icosanoid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in icosanoid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in kidney development	IBA Inferred from Biological aspect of Ancestor more info
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in lauric acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lauric acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in linoleic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in linoleic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 4A2

Names: CYPIVA2; P-450 IV4AII; P-450 K-2; P450 K-5; P450-LA-omega 2; cytochrome P-450 K-2; cytochrome P450 4A2-like; cytochrome P450 K-5; cytochrome P450, subfamily 4A, polypeptide 11; cytochrome P450, subfamily IVA, polypeptide 11; cytochrome P450-LA-omega 2; lauric acid omega-hydroxylase; long-chain fatty acid omega-monooxygenase

NP_001038235.1

EC 1.14.14.80

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044770.2 → NP_001038235.1 cytochrome P450 4A2

See identical proteins and their annotated locations for NP_001038235.1

Status: PROVISIONAL

Source sequence(s)

BC078684

UniProtKB/Swiss-Prot

P20816, Q4G071

UniProtKB/TrEMBL

F1M7X1

Related

ENSRNOP00000082696.1, ENSRNOT00000111375.1

Conserved Domains (1) summary

cd20678
Location:69 → 499

CYP4B-like; cytochrome P450 family 4, subfamily B and similar cytochrome P450s, including subfamilies A, T, X, and Z