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    Fmo5 flavin containing dimethylaniline monoxygenase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246248, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Fmo5provided by RGD
    Official Full Name
    flavin containing dimethylaniline monoxygenase 5provided by RGD
    Primary source
    RGD:628602
    See related
    Ensembl:ENSRNOG00000018076 AllianceGenome:RGD:628602
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables N,N-dimethylaniline monooxygenase activity. Predicted to be involved in NADPH oxidation; regulation of cholesterol metabolic process; and xenobiotic metabolic process. Predicted to be located in cytosol and endoplasmic reticulum. Orthologous to human FMO5 (flavin containing dimethylaniline monoxygenase 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 562.3), Kidney (RPKM 121.6) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q34
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (187885741..187938468)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (185197184..185249699)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (199796870..199823927)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 13 subfamily L member 2 Neighboring gene olfactory receptor pseudogene 391 Neighboring gene chromodomain helicase DNA binding protein 1-like Neighboring gene uncharacterized LOC102550575 Neighboring gene protein kinase AMP-activated non-catalytic subunit beta 2 Neighboring gene transfer RNA glutamine (anticodon CUG) 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Physiological factors affecting protein expression of flavin-containing monooxygenases 1, 3 and 5. Cherrington NJ, et al. Xenobiotica, 1998 Jul. PMID 9711811
    2. Baeyer-Villiger Monooxygenase FMO5 as Entry Point in Drug Metabolism. Fiorentini F, et al. ACS Chem Biol, 2017 Sep 15. PMID 28783300
    3. Biocatalytic Characterization of Human FMO5: Unearthing Baeyer-Villiger Reactions in Humans. Fiorentini F, et al. ACS Chem Biol, 2016 Apr 15. PMID 26771671
    4. The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing. Gonzalez Malagon SG, et al. Biochem Pharmacol, 2015 Aug 1. PMID 26049045, Free PMC Article
    5. A Baeyer-Villiger oxidation specifically catalyzed by human flavin-containing monooxygenase 5. Lai WG, et al. Drug Metab Dispos, 2011 Jan. PMID 20947616

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N,N-dimethylaniline monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N,N-dimethylaniline monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N,N-dimethylaniline monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD(P)H oxidase H2O2-forming activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADPH oxidase H202-forming activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aldehyde oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aldehyde oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aldehyde oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hypotaurine dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADPH oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NADPH oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in NADPH oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cholesterol metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in xenobiotic metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    flavin-containing monooxygenase 5
    Names
    FMO 5
    NADPH oxidase
    NAPDH oxidase
    dimethylaniline monooxygenase [N-oxide-forming] 5
    dimethylaniline oxidase 5
    flavin containing monooxygenase 5
    hepatic flavin-containing monooxygenase 5
    NP_653340.2
    XP_038957658.1
    XP_063137367.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144739.2 → NP_653340.2  flavin-containing monooxygenase 5

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q6IRL0, Q8K4C0
      UniProtKB/TrEMBL
      A0A0G2JSQ2, A6K3B5
      Related
      ENSRNOP00000024423.2, ENSRNOT00000024423.6
      Conserved Domains (1) summary
      pfam00743
      Location:3 → 532
      FMO-like; Flavin-binding monooxygenase-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      187885741..187938468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281297.1 → XP_063137367.1  flavin-containing monooxygenase 5 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JSQ2, A6K3B5

    2. XM_039101730.2 → XP_038957658.1  flavin-containing monooxygenase 5 isoform X1

      UniProtKB/Swiss-Prot
      Q6IRL0, Q8K4C0
      UniProtKB/TrEMBL
      A0A0G2JSQ2, A6K3B5
      Conserved Domains (1) summary
      pfam00743
      Location:3 → 532
      FMO-like; Flavin-binding monooxygenase-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K4C0.3 GenPept UniProtKB/Swiss-Prot:Q8K4C0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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