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    Tank TRAF family member-associated Nf-kappa B activator [ Mus musculus (house mouse) ]

    Gene ID: 21353, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tankprovided by MGI
    Official Full Name
    TRAF family member-associated Nf-kappa B activatorprovided by MGI
    Primary source
    MGI:MGI:107676
    See related
    Ensembl:ENSMUSG00000064289 AllianceGenome:MGI:107676
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    I-TRAF; E430026L09Rik
    Summary
    Predicted to enable deubiquitinase activator activity and ubiquitin protein ligase binding activity. Predicted to contribute to thiol-dependent deubiquitinase. Acts upstream of or within I-kappaB kinase/NF-kappaB signaling. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human TANK (TRAF family member associated NFKB activator). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 6.0), frontal lobe adult (RPKM 5.6) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 C1.3; 2 35.56 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (61408901..61484515)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (61578557..61654171)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4455 Neighboring gene STARR-positive B cell enhancer ABC_E4456 Neighboring gene STARR-positive B cell enhancer mm9_chr2:61332470-61332771 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene Neighboring gene predicted gene, 33841 Neighboring gene STARR-seq mESC enhancer starr_04631 Neighboring gene STARR-positive B cell enhancer ABC_E808 Neighboring gene STARR-positive B cell enhancer ABC_E5924 Neighboring gene STARR-positive B cell enhancer ABC_E506 Neighboring gene STARR-positive B cell enhancer ABC_E7821 Neighboring gene STARR-positive B cell enhancer mm9_chr2:61481154-61481454 Neighboring gene STARR-seq mESC enhancer starr_04632 Neighboring gene STARR-positive B cell enhancer ABC_E4457 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 Neighboring gene T-box brain transcription factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TANK prevents IFN-dependent fatal diffuse alveolar hemorrhage by suppressing DNA-cGAS aggregation. Wakabayashi A, et al. Life Sci Alliance, 2022 Feb. PMID 34819357, Free PMC Article
    2. TRAF family member-associated NF-κB activator (TANK) induced by RANKL negatively regulates osteoclasts survival and function. Wu M, et al. Int J Biol Sci, 2012. PMID 23139637, Free PMC Article
    3. TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation. Maruyama K, et al. J Biol Chem, 2012 Aug 17. PMID 22773835, Free PMC Article
    4. TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation. Cheng G, et al. Genes Dev, 1996 Apr 15. PMID 8608943
    5. TANK Promotes Pressure Overload Induced Cardiac Hypertrophy via Activating AKT Signaling Pathway. Pang Y, et al. Front Cardiovasc Med, 2021. PMID 34540911, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Findings suggest that the cortical neuroimmune regulator TANK is involved in cortical aversive emotion processing and related control of alcohol drinking behavior. A tank knock out mouse model suggests a role of TANK in alcohol drinking, anxiety-related behavior, as well as alcohol exposure induced activation of insular cortex NF-kappaB.
      Title: The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study.
    2. TANK is expressed in DRG neurons. TANK is increased by peripheral nerve injury. the regulation of TANK expression is, at least in part, controlled by the injury-associated transcription factor Sox11.
      Title: TRAF family member-associated NF-kappa B activator (TANK) expression increases in injured sensory neurons and is transcriptionally regulated by Sox11.
    3. Tank, whose expression is increased during osteoclastogenesis, inhibits osteoclast formation, activity and survival, by regulating NF-kappaB activity and c-FLIP expression.
      Title: TRAF family member-associated NF-κB activator (TANK) induced by RANKL negatively regulates osteoclasts survival and function.
    4. TANK is critical for osteoclastogenesis by regulating NF-kappaB, and is also important for proper bone remodeling.
      Title: TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation.
    5. role for TANK in enabling the canonical IKKs and the IKK-related kinases to regulate each other, which is required to limit the strength of TLR signaling and ultimately, prevent autoimmunity
      Title: The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling.
    6. MARCH5 is an authentic E3 ubiquitin ligase and catalyzes K63-linked polyubiquitination of TANK. MARCH5 modulates TLR7 signaling via releasing the inhibitory action of TANK toward TRAF6.
      Title: Mitochondrial ubiquitin ligase MARCH5 promotes TLR7 signaling by attenuating TANK action.
    7. constitutive TLR signaling by intestinal commensal microflora is suppressed by TANK.
      Title: TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis.
    8. TANK may be a critical adaptor that regulates the assembly of the TANK-binding kinase 1-inducible IkappaB kinase complex with upstream signaling molecules in multiple antiviral pathways
      Title: Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables deubiquitinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular function inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ubiquitin-specific protease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TRAF family member-associated NF-kappa-B activator
    Names
    TRAF-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164071.1 → NP_001157543.1  TRAF family member-associated NF-kappa-B activator isoform 1

      See identical proteins and their annotated locations for NP_001157543.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 4 both encode the same isoform (1).
      Source sequence(s)
      AK147727, AL845291, BB660164
      Consensus CDS
      CCDS50592.1
      UniProtKB/TrEMBL
      Q3UGW0
      Related
      ENSMUSP00000108120.3, ENSMUST00000112501.9
      Conserved Domains (1) summary
      pfam12845
      Location:134 → 185
      TBD; TBD domain

    2. NM_001164072.1 → NP_001157544.1  TRAF family member-associated NF-kappa-B activator isoform 2

      See identical proteins and their annotated locations for NP_001157544.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks one internal residue, compared to isoform 1.
      Source sequence(s)
      AK147727, AK165420, AL845291, BB660164
      Consensus CDS
      CCDS50593.1
      UniProtKB/TrEMBL
      Q3TNB4, Q8C2D3
      Related
      ENSMUSP00000108114.2, ENSMUST00000112495.8
      Conserved Domains (2) summary
      pfam05557
      Location:25 → 83
      MAD; Mitotic checkpoint protein
      pfam12845
      Location:131 → 184
      TBD; TBD domain

    3. NM_001355267.1 → NP_001342196.1  TRAF family member-associated NF-kappa-B activator isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4 both encode the same isoform (1).
      Source sequence(s)
      AL845291, AL928859
      Consensus CDS
      CCDS50592.1
      UniProtKB/TrEMBL
      Q3UGW0
      Conserved Domains (1) summary
      pfam12845
      Location:134 → 185
      TBD; TBD domain

    4. NM_001355268.1 → NP_001342197.1  TRAF family member-associated NF-kappa-B activator isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL845291, AL928859
      Related
      ENSMUST00000141544.8
      Conserved Domains (1) summary
      pfam12845
      Location:2 → 52
      TBD; TBD domain

    5. NM_001374667.1 → NP_001361596.1  TRAF family member-associated NF-kappa-B activator isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL845291, AL928859
      Consensus CDS
      CCDS89491.1
      UniProtKB/TrEMBL
      A2AR76, Q3TNB4
      Related
      ENSMUSP00000108121.2, ENSMUST00000112502.8
      Conserved Domains (2) summary
      pfam05557
      Location:59 → 117
      MAD; Mitotic checkpoint protein
      pfam12845
      Location:165 → 218
      TBD; TBD domain

    6. NM_001378922.1 → NP_001365851.1  TRAF family member-associated NF-kappa-B activator isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL845291, AL928859
      Conserved Domains (1) summary
      pfam12845
      Location:2 → 51
      TBD; TBD domain

    7. NM_011529.2 → NP_035659.1  TRAF family member-associated NF-kappa-B activator isoform 3

      See identical proteins and their annotated locations for NP_035659.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR and uses an upstream start codon, compared to variant 1. The resulting isoform (3) has a longer N-terminus, compared to isoform 1.
      Source sequence(s)
      AL845291, U59864
      Consensus CDS
      CCDS16061.1
      UniProtKB/Swiss-Prot
      P70347, Q61178
      UniProtKB/TrEMBL
      Q3UGW0
      Related
      ENSMUSP00000077219.3, ENSMUST00000078074.9
      Conserved Domains (1) summary
      pfam12845
      Location:166 → 218
      TBD; TBD domain

    RNA

    1. NR_149323.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL845291, AL928859

    2. NR_149324.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL845291, AL928859

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      61408901..61484515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160230.1 → XP_036016123.1  TRAF family member-associated NF-kappa-B activator isoform X1

      UniProtKB/TrEMBL
      A2AR78
      Conserved Domains (1) summary
      pfam12845
      Location:166 → 218
      TBD; TBD domain

    2. XM_036160231.1 → XP_036016124.1  TRAF family member-associated NF-kappa-B activator isoform X3

      UniProtKB/TrEMBL
      A2AR78
      Conserved Domains (1) summary
      pfam12845
      Location:132 → 184
      TBD; TBD domain

    3. XM_036160232.1 → XP_036016125.1  TRAF family member-associated NF-kappa-B activator isoform X4

      UniProtKB/TrEMBL
      A2AR78
      Conserved Domains (1) summary
      pfam12845
      Location:131 → 183
      TBD; TBD domain

    4. XM_017316913.3 → XP_017172402.1  TRAF family member-associated NF-kappa-B activator isoform X2

      UniProtKB/TrEMBL
      Q3TNB4, Q8C2D3
      Conserved Domains (2) summary
      pfam05557
      Location:25 → 83
      MAD; Mitotic checkpoint protein
      pfam12845
      Location:131 → 184
      TBD; TBD domain

    5. XM_036160236.1 → XP_036016129.1  TRAF family member-associated NF-kappa-B activator isoform X5

      Conserved Domains (1) summary
      pfam12845
      Location:2 → 51
      TBD; TBD domain

    6. XM_036160233.1 → XP_036016126.1  TRAF family member-associated NF-kappa-B activator isoform X5

      Conserved Domains (1) summary
      pfam12845
      Location:2 → 51
      TBD; TBD domain

    7. XM_036160237.1 → XP_036016130.1  TRAF family member-associated NF-kappa-B activator isoform X5

      Conserved Domains (1) summary
      pfam12845
      Location:2 → 51
      TBD; TBD domain

    8. XM_036160235.1 → XP_036016128.1  TRAF family member-associated NF-kappa-B activator isoform X5

      Conserved Domains (1) summary
      pfam12845
      Location:2 → 51
      TBD; TBD domain

    9. XM_036160234.1 → XP_036016127.1  TRAF family member-associated NF-kappa-B activator isoform X5

      Conserved Domains (1) summary
      pfam12845
      Location:2 → 51
      TBD; TBD domain

    RNA

    1. XR_866264.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70347.1 GenPept UniProtKB/Swiss-Prot:P70347

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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