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    Simc1 SUMO-interacting motifs containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 319719, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Simc1provided by MGI
    Official Full Name
    SUMO-interacting motifs containing 1provided by MGI
    Primary source
    MGI:MGI:2442599
    See related
    Ensembl:ENSMUSG00000043183 AllianceGenome:MGI:2442599
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4732471D19Rik
    Summary
    Predicted to enable SUMO polymer binding activity and peptidase inhibitor activity. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in sarcomere. Orthologous to human SIMC1 (SUMO interacting motifs containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 8.4), CNS E18 (RPKM 7.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 B1; 13 28.74 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54651539..54699103)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54503739..54551290)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene THO complex 3 Neighboring gene STARR-positive B cell enhancer ABC_E10794 Neighboring gene predicted gene, 53205 Neighboring gene STARR-positive B cell enhancer ABC_E7241 Neighboring gene predicted gene 2830 Neighboring gene RIKEN cDNA 4833439L19 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:54666808-54666917 Neighboring gene predicted gene, 24195 Neighboring gene STARR-positive B cell enhancer ABC_E927 Neighboring gene ADP-ribosylation factor-like 10 Neighboring gene NOP16 nucleolar protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SUMO polymer binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO polymer binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables peptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcomere ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SUMO-interacting motif-containing protein 1
    Names
    platform element for inhibition of autolytic degradation

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176987.5 → NP_795961.3  SUMO-interacting motif-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      AC155262, AC165145
      Consensus CDS
      CCDS26528.2
      UniProtKB/Swiss-Prot
      E9Q6E9, Q3TM32, Q8C747, Q8CE66
      Related
      ENSMUSP00000113676.2, ENSMUST00000121401.8
      Conserved Domains (2) summary
      PHA02682
      Location:194 → 283
      PHA02682; ORF080 virion core protein; Provisional
      pfam09606
      Location:414 → 807
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      54651539..54699103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244528.2 → XP_011242830.1  SUMO-interacting motif-containing protein 1 isoform X1

      Conserved Domains (2) summary
      PHA02682
      Location:194 → 283
      PHA02682; ORF080 virion core protein; Provisional
      pfam09606
      Location:327 → 693
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    2. XM_011244529.2 → XP_011242831.1  SUMO-interacting motif-containing protein 1 isoform X2

      Conserved Domains (2) summary
      PHA02682
      Location:194 → 283
      PHA02682; ORF080 virion core protein; Provisional
      pfam09606
      Location:369 → 772
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    3. XM_036158068.1 → XP_036013961.1  SUMO-interacting motif-containing protein 1 isoform X4

      Conserved Domains (2) summary
      PHA02682
      Location:86 → 175
      PHA02682; ORF080 virion core protein; Provisional
      PHA03307
      Location:413 → 712
      PHA03307; transcriptional regulator ICP4; Provisional

    4. XM_017315526.2 → XP_017171015.1  SUMO-interacting motif-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      Q8R1V0

    5. XM_011244530.1 → XP_011242832.1  SUMO-interacting motif-containing protein 1 isoform X3

      See identical proteins and their annotated locations for XP_011242832.1

      Conserved Domains (2) summary
      PHA02682
      Location:86 → 175
      PHA02682; ORF080 virion core protein; Provisional
      pfam09606
      Location:219 → 585
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    6. XM_030247294.1 → XP_030103154.1  SUMO-interacting motif-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      Q8R1V0

    7. XM_011244531.1 → XP_011242833.1  SUMO-interacting motif-containing protein 1 isoform X3

      See identical proteins and their annotated locations for XP_011242833.1

      Conserved Domains (2) summary
      PHA02682
      Location:86 → 175
      PHA02682; ORF080 virion core protein; Provisional
      pfam09606
      Location:219 → 585
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q6E9.1 GenPept UniProtKB/Swiss-Prot:E9Q6E9

    Gene LinkOut

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