Fshb follicle stimulating hormone subunit beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fshbprovided by RGD
Official Full Name: follicle stimulating hormone subunit betaprovided by RGD
Primary source: RGD:2630
See related: Ensembl:ENSRNOG00000004898 AllianceGenome:RGD:2630
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: FSH-B; FSH-beta
Summary: Predicted to enable follicle-stimulating hormone activity. Predicted to be involved in several processes, including follicle-stimulating hormone signaling pathway; positive regulation of steroid biosynthetic process; and transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within several processes, including gonad development; positive regulation of bone resorption; and regulation of osteoclast differentiation. Predicted to be part of follicle-stimulating hormone complex. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in amenorrhea and hypogonadotropic hypogonadism 24 without anosmia. Orthologous to human FSHB (follicle stimulating hormone subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 6.3), Testes (RPKM 3.0) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 3q33

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (114003262..114007072, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (93548560..93552370, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (98088321..98092131, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study in primary rat pituitary cells demonstrates that miR-186-5p regulates FSH secretion by directly targeting the FSHb 3' UTR.
Title: Regulation of FSH expression by differentially expressed miR-186-5p in rat anterior adenohypophyseal cells.
our results indicate that miR-21-3p and miR-433 can down-regulate the expression of FSHb by directly targeting the FSHb 3'UTR in rat primary pituitary cells.
Title: Roles of differential expression of microRNA-21-3p and microRNA-433 in FSH regulation in rat anterior pituitary cells.
the upstream region of Fshb is susceptible to unsaturated long-chain fatty acids
Title: Long-chain unsaturated fatty acids reduce the transcriptional activity of the rat follicle-stimulating hormone β-subunit gene.
The study uncovers a new role for AMH in regulating gonadotrope function and suggests that AMH participates in the postnatal elevation of FSH secretion in females.
Title: Anti-Müllerian hormone: a new actor of sexual dimorphism in pituitary gonadotrope activity before puberty.
GnRH stimulation of Fshb expression is dependent on miR-132/212 and involves a SIRT1-FOXO1 pathway.
Title: Rapid communication: A microRNA-132/212 pathway mediates GnRH activation of FSH expression.
FSH acutely regulated CCND2 expression through both PKA and PI3K signaling pathways during granulosa cell proliferation and also accelerated its ubiquitination-proteasomal degradation.
Title: Regulation of cyclin D2 expression and degradation by follicle-stimulating hormone during rat granulosa cell proliferation in vitro.
Data suggest that FSH (Cga/FSHb) induces clock system in granulosa cells by up-regulation of connexin 43 expression; this suggests that gap junctions are implicated in circadian clock in peripheral oscillators besides central pacemaker.
Title: FSH induces the development of circadian clockwork in rat granulosa cells via a gap junction protein Cx43-dependent pathway.
Both the hormonal milieu of perimenopause and the association of dynamic perimenopausal changes in FSH and inhibin A with decreased bone mineral density have been reproduced in an animal model.
Title: Decreased bone mineral density in rats rendered follicle-deplete by an ovotoxic chemical correlates with changes in follicle-stimulating hormone and inhibin A.
FSH autoantibody could cause the reduction of inhibin B, thereby inducing hypospermatogenesis via augment of spermatogenic cell apoptosis
Title: The effect of induced anti-follicle-stimulating hormone autoantibody on serum hormone level and apoptosis in rat testis.
Novel findings supporting the role of FSH in primordial follicle survival through an action on apoptosis.
Title: The effects of FSH and activin A on follicle development in vitro.

Submit: New GeneRIF Correction See all GeneRIFs (32)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables follicle-stimulating hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables follicle-stimulating hormone activity	ISO Inferred from Sequence Orthology more info
enables follicle-stimulating hormone activity	ISS Inferred from Sequence or Structural Similarity more info
enables follicle-stimulating hormone activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within Sertoli cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in follicle-stimulating hormone signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within follicle-stimulating hormone signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in follicle-stimulating hormone signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within ovarian follicle development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of bone resorption	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of steroid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
part_of follicle-stimulating hormone complex	ISO Inferred from Sequence Orthology more info
part_of follicle-stimulating hormone complex	ISS Inferred from Sequence or Structural Similarity more info
part_of follicle-stimulating hormone complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: follitropin subunit beta

Names: follicle - stimulating hormone subunit beta; follicle stimulating hormone beta subunit; follicle stimulating hormone, beta polypeptide; follitropin beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.