Aox2 aldehyde oxidase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aox2provided by MGI
Official Full Name: aldehyde oxidase 2provided by MGI
Primary source: MGI:MGI:3529596
See related: Ensembl:ENSMUSG00000079554 AllianceGenome:MGI:3529596
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Aoh3; Aox3l1
Summary: Predicted to enable aldehyde oxidase activity. Predicted to be located in cytoplasm. Is expressed in nervous system; nose; and olfactory epithelium. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 1 C1.3; 1 29.0 cM

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (58317485..58418423)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (58278326..58379264)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Although mAOX2 and mAOX3 are very similar to each other, we propose the following pairs of overlapping substrate specificities: mAOX2/mAOX4 and mAOX3/mAXO1.
Title: Insights into the structural determinants of substrate specificity and activity in mouse aldehyde oxidases.
selectively expressed in Bowman's glands of the olfactory mucosa
Title: The aldehyde oxidase gene cluster in mice and rats. Aldehyde oxidase homologue 3, a novel member of the molybdo-flavoenzyme family with selective expression in the olfactory mucosa.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Aox3l1 (e-PCR), detects polymorphism
- UniSTS:546656

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables aldehyde oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: aldehyde oxidase 2

Names: aldehyde oxidase 3-like 1; aldehyde oxidase homolog 3; aldehyde oxidase-like protein 3; azaheterocycle hydroxylase 2

NP_001008419.1

EC 1.2.3.1

XP_017175142.1

EC 1.2.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008419.2 → NP_001008419.1 aldehyde oxidase 2

See identical proteins and their annotated locations for NP_001008419.1

Status: VALIDATED

Source sequence(s)

AC121091, AC163498

Consensus CDS

CCDS35576.1

UniProtKB/Swiss-Prot

B9EKC6, Q5SGK3

Related

ENSMUSP00000110006.2, ENSMUST00000114366.3

Conserved Domains (7) summary

TIGR02969
Location:10 → 1344

mam_aldehyde_ox; aldehyde oxidase

smart01008
Location:604 → 706

Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain

cd00207
Location:11 → 84

fer2; 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis ...

pfam00941
Location:241 → 421

FAD_binding_5; FAD binding domain in molybdopterin dehydrogenase

pfam01799
Location:92 → 163

Fer2_2; [2Fe-2S] binding domain

pfam02738
Location:721 → 1251

Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase

pfam03450
Location:428 → 532

CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

58317485..58418423

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017319653.3 → XP_017175142.1 aldehyde oxidase 2 isoform X1

Conserved Domains (1) summary

TIGR02969
Location:10 → 1329

mam_aldehyde_ox; aldehyde oxidase