Grxcr1 glutaredoxin and cysteine rich domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Grxcr1provided by RGD
Full Name: glutaredoxin and cysteine rich domain containing 1provided by RGD
Primary source: RGD:1564635
See related: Ensembl:ENSRNOG00000038891 AllianceGenome:RGD:1564635
Gene type: protein coding
RefSeq status: INFERRED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564635
Summary: Predicted to enable glutathione oxidoreductase activity. Predicted to be involved in inner ear receptor cell stereocilium organization and vestibular receptor cell development. Predicted to act upstream of or within inner ear auditory receptor cell differentiation; post-embryonic animal organ morphogenesis; and sensory perception of sound. Predicted to be active in kinocilium and stereocilium. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 25. Orthologous to human GRXCR1 (glutaredoxin and cysteine rich domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 14.0), Lung (RPKM 1.8) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (40358077..40480493, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (40004169..40126571, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (41663688..41787331, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within cochlea development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear auditory receptor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear development	ISO Inferred from Sequence Orthology more info
involved_in inner ear receptor cell development	ISO Inferred from Sequence Orthology more info
involved_in inner ear receptor cell stereocilium organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in inner ear receptor cell stereocilium organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in vestibular receptor cell development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in kinocilium	IBA Inferred from Biological aspect of Ancestor more info
located_in kinocilium	ISO Inferred from Sequence Orthology more info
is_active_in stereocilium	IBA Inferred from Biological aspect of Ancestor more info
located_in stereocilium	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutaredoxin domain-containing cysteine-rich protein 1

Names: glutaredoxin domain-containing cysteine-rich protein 1-like; glutaredoxin, cysteine rich 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191935.1 → NP_001178864.1 glutaredoxin domain-containing cysteine-rich protein 1

Status: INFERRED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

D4A048

Related

ENSRNOP00000056195.3, ENSRNOT00000059439.5

Conserved Domains (1) summary

cd03031
Location:138 → 285

GRX_GRX_like; Glutaredoxin (GRX) family, GRX-like domain containing protein subfamily; composed of uncharacterized eukaryotic proteins containing a GRX-like domain having only one conserved cysteine, aligning to the C-terminal cysteine of the CXXC motif of GRXs. This ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

40358077..40480493 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092286.1 → XP_038948214.1 glutaredoxin domain-containing cysteine-rich protein 1 isoform X1

Conserved Domains (1) summary

cd03031
Location:57 → 204

GRX_GRX_like; Glutaredoxin (GRX) family, GRX-like domain containing protein subfamily; composed of uncharacterized eukaryotic proteins containing a GRX-like domain having only one conserved cysteine, aligning to the C-terminal cysteine of the CXXC motif of GRXs. This ...