Eip75B Ecdysone-induced protein 75B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Eip75Bprovided by FlyBase
Official Full Name: Ecdysone-induced protein 75Bprovided by FlyBase
Primary source: FLYBASE:FBgn0000568
Locus tag: Dmel_CG8127
See related: AllianceGenome:FB:FBgn0000568
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 57B; 75B; anon-WO0172774.31; anon-WO0172774.32; BcDNA:GM02640; CG8127; dE75; DmE75; DmE75A; DmE75B; Dmel\CG8127; E75; E75-C; E75A; E75B; E75C; Eip75; EiP75; Eip75 A; eip75a; Eip75A; eip75B; EP1121b; l(3)07041; l(3)j11A6; l(3)j12E8; l(3)j3A6; l(3)j5E1; l(3)neo25; Mgn00274; NR1D3; Rev-Erb; REV-ERB&agr
Summary: Enables DNA binding activity and heme binding activity. Involved in several processes, including ecdysis, chitin-based cuticle; regulation of ecdysteroid metabolic process; and response to ecdysone. Located in nucleus. Is expressed in several structures, including embryonic/larval digestive system; embryonic/larval nervous system; endocrine system component; epithelium; and nephrocyte. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); end stage renal disease; endocrine gland cancer (multiple); lipodystrophy (multiple); and proliferative diabetic retinopathy. Orthologous to several human genes including NR1D2 (nuclear receptor subfamily 1 group D member 2); PPARA (peroxisome proliferator activated receptor alpha); and PPARG (peroxisome proliferator activated receptor gamma). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 75A10-75B6; 3-45 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (17950953..18064696, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (17944053..18057796, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Single Nucleotide Variant in the PPARgamma-homolog Eip75B Affects Fecundity in Drosophila.
Title: A Single Nucleotide Variant in the PPARγ-homolog Eip75B Affects Fecundity in Drosophila.
These results suggest that E75C, like UNF, is required for developmental regrowth, but not initial outgrowth of mushroom body gamma axons.
Title: Nitric Oxide as a Switching Mechanism between Axon Degeneration and Regrowth during Developmental Remodeling.
E75 and UNF bind to PER regulatory sequences and act together to enhance the CLK/CYC-mediated transcription of the PER gene.
Title: Transcriptional regulation via nuclear receptor crosstalk required for the Drosophila circadian clock.
E75 and ecdysone receptor are expressed in central clock cells, and manipulations of their expression produce drastic effects on circadian rhythms in Drosophila.
Title: An ecdysone-responsive nuclear receptor regulates circadian rhythms in Drosophila.
Ecdysone and NO mediate gene regulation by competing EcR/Usp and E75A nuclear receptors during Drosophila development
Title: Ecdysone- and NO-mediated gene regulation by competing EcR/Usp and E75A nuclear receptors during Drosophila development.
Covalent attachment of heme to the protein moiety in an insect E75 nitric oxide sensor.
Title: Covalent attachment of heme to the protein moiety in an insect E75 nitric oxide sensor.
FTZ-F1 functions as a competence factor by loading juvenile hormone (JH) signaling components to the promoter, thus facilitating the direct regulation of E75A gene expression by JH.
Title: The Drosophila FTZ-F1 nuclear receptor mediates juvenile hormone activation of E75A gene expression through an intracellular pathway.
nitric oxide is produced in the Drosophila prothoracic gland, where it acts via the nuclear receptor ecdysone-induced protein 75 (E75), reversing its ability to interfere with its heterodimer partner, Drosophila hormone receptor 3 (DHR3).
Title: Nitric oxide coordinates metabolism, growth, and development via the nuclear receptor E75.
the ligand binding pocket of the Drosophila nuclear receptor E75 contains a heme prosthetic group and may also function as a diatomic gas sensor
Title: The Drosophila nuclear receptor e75 contains heme and is gas responsive.
E75 is a new example of a thiolate hemoprotein that may be involved in hormone synthesis regulation.
Title: Drosophila nuclear receptor E75 is a thiolate hemoprotein.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in ecdysis, chitin-based cuticle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in molting cycle, chitin-based cuticle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in oogenesis	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of ecdysteroid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ecdysone	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Ecdysone-induced protein 75B

Names: CG8127-PA; CG8127-PB; CG8127-PC; CG8127-PD; CG8127-PE; CG8127-PF; CG8127-PG; E75 nuclear receptor; Eip75B-PA; Eip75B-PB; Eip75B-PC; Eip75B-PD; Eip75B-PE; Eip75B-PF; Eip75B-PG; ecdysone induced protein 75; ecdysone inducible protein 75B; ecdysone-induced protein 75

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

17950953..18064696 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001259893.2 → NP_001246822.1 Ecdysone-induced protein 75B, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246822.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P13055, Q9VVM9

UniProtKB/TrEMBL

M9NED3

Conserved Domains (2) summary

cd06940
Location:609 → 796

NR_LBD_REV_ERB; The ligand binding domain of REV-ERB receptors, members of the nuclear receptor superfamily

cd07166
Location:453 → 541

NR_DBD_REV_ERB; DNA-binding domain of REV-ERB receptor-like is composed of two C4-type zinc fingers
NM_168756.2 → NP_730322.1 Ecdysone-induced protein 75B, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730322.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B3DN68, B3DN69, P17671, Q8IQS1, Q8IQS3

Related

FBpp0074915

Conserved Domains (2) summary

cd06940
Location:396 → 583

NR_LBD_REV_ERB; The ligand binding domain of REV-ERB receptors, members of the nuclear receptor superfamily

cd07166
Location:240 → 328

NR_DBD_REV_ERB; DNA-binding domain of REV-ERB receptor-like is composed of two C4-type zinc fingers
NM_079409.3 → NP_524133.2 Ecdysone-induced protein 75B, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524133.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P17672, Q8IQS2

Related

FBpp0074916

Conserved Domains (2) summary

cd06940
Location:552 → 739

NR_LBD_REV_ERB; The ligand binding domain of REV-ERB receptors, members of the nuclear receptor superfamily

cl02596
Location:415 → 484

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
NM_001259892.1 → NP_001246821.1 Ecdysone-induced protein 75B, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246821.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P13055, Q9VVM9

UniProtKB/TrEMBL

M9NED3

Conserved Domains (2) summary

cd06940
Location:609 → 796

NR_LBD_REV_ERB; The ligand binding domain of REV-ERB receptors, members of the nuclear receptor superfamily

cd07166
Location:453 → 541

NR_DBD_REV_ERB; DNA-binding domain of REV-ERB receptor-like is composed of two C4-type zinc fingers
NM_168755.1 → NP_730321.1 Ecdysone-induced protein 75B, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730321.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P13055, Q9VVM9

UniProtKB/TrEMBL

M9NED3

Related

FBpp0074914, FBtr0075148

Conserved Domains (2) summary

cd06940
Location:609 → 796

NR_LBD_REV_ERB; The ligand binding domain of REV-ERB receptors, members of the nuclear receptor superfamily

cd07166
Location:453 → 541

NR_DBD_REV_ERB; DNA-binding domain of REV-ERB receptor-like is composed of two C4-type zinc fingers
NM_001316451.1 → NP_001303380.1 Ecdysone-induced protein 75B, isoform G [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0S0WIG6

Conserved Domains (2) summary

cd06940
Location:188 → 375

NR_LBD_REV_ERB; The ligand binding domain of REV-ERB receptors, members of the nuclear receptor superfamily

cd07166
Location:32 → 120

NR_DBD_REV_ERB; DNA-binding domain of REV-ERB receptor-like is composed of two C4-type zinc fingers
NM_168757.1 → NP_730323.1 Ecdysone-induced protein 75B, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730323.1

Status: REVIEWED

UniProtKB/TrEMBL

E3CTP0

Related

FBpp0074917, FBtr0075151

Conserved Domains (1) summary

cd06940
Location:103 → 290

NR_LBD_REV_ERB; The ligand binding domain of REV-ERB receptors, members of the nuclear receptor superfamily