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    clumsy [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35394, updated on 26-Apr-2024

    Summary

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    Official Symbol
    clumsyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026255
    Locus tag
    Dmel_CG8681
    See related
    AllianceGenome:FB:FBgn0026255
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8681; Clumsy; CT9037; Dmelclumsy; Dmel\CG8681; GluR39B
    Summary
    Predicted to enable kainate selective glutamate receptor activity and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and regulation of synaptic activity. Predicted to be active in postsynaptic membrane. Is expressed in adult head and transmedullary neuron Tm5c. Human ortholog(s) of this gene implicated in Huntington's disease; autosomal recessive non-syndromic intellectual disability; autosomal recessive spinocerebellar ataxia 18; and childhood absence epilepsy. Orthologous to several human genes including GRIK1 (glutamate ionotropic receptor kainate type subunit 1); GRIK2 (glutamate ionotropic receptor kainate type subunit 2); and GRIK3 (glutamate ionotropic receptor kainate type subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    39B2-39B3; 2-54 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21206493..21211818)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21206493..21211818)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Autophagy-related 18b Neighboring gene small nuclear RNA U4 at 39B Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel Functional Properties of Drosophila CNS Glutamate Receptors. Li Y, et al. Neuron, 2016 Dec 7. PMID 27889096, Free PMC Article
    2. An essential Drosophila glutamate receptor subunit that functions in both central neuropil and neuromuscular junction. Featherstone DE, et al. J Neurosci, 2005 Mar 23. PMID 15788777, Free PMC Article
    3. A hard-wired glutamatergic circuit pools and relays UV signals to mediate spectral preference in Drosophila. Karuppudurai T, et al. Neuron, 2014 Feb 5. PMID 24507194, Free PMC Article
    4. Autocrine inhibition by a glutamate-gated chloride channel mediates presynaptic homeostatic depression. Li X, et al. Sci Adv, 2021 Dec 3. PMID 34851664, Free PMC Article
    5. Ih channels control feedback regulation from amacrine cells to photoreceptors. Hu W, et al. PLoS Biol, 2015 Apr. PMID 25831426, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 21208280-21208883 mobile_element_type = transposon:INE-1{}5397
    • Loc: 21208596-21208773 mobile_element_type = transposon:FB{}2221
    • Loc: 21209403-21209484 mobile_element_type = transposon:INE-1{}5399

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kainate selective glutamate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synaptic activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    clumsy
    Names
    CG8681-PA
    CG8681-PB
    clumsy-PA
    clumsy-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21206493..21211818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042908.2 → NP_001036373.1  clumsy, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036373.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8N6
      Conserved Domains (4) summary
      cd06382
      Location:26 → 396
      PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors
      cd13714
      Location:414 → 787
      PBP2_iGluR_Kainate; Kainate receptor of the type 2 periplasmic-binding fold superfamily
      pfam00060
      Location:548 → 812
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:39 → 379
      ANF_receptor; Receptor family ligand binding region

    2. NM_078886.3 → NP_523610.2  clumsy, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523610.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIE2
      Related
      FBpp0081005
      Conserved Domains (4) summary
      cd06382
      Location:1 → 324
      PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors
      cd13714
      Location:342 → 686
      PBP2_iGluR_Kainate; Kainate receptor of the type 2 periplasmic-binding fold superfamily
      pfam00060
      Location:476 → 684
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:3 → 307
      ANF_receptor; Receptor family ligand binding region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0E8N6 Q0E8N6
    Q8SYJ0 Q8SYJ0
    Q9VIE2 Q9VIE2

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