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    FASN3 Fatty acid synthase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355111, updated on 10-May-2024

    Summary

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    Official Symbol
    FASN3provided by FlyBase
    Official Full Name
    Fatty acid synthase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0287184
    Locus tag
    Dmel_CG17374
    See related
    AllianceGenome:FB:FBgn0287184
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    80Ff; CG17374; Dmel\CG17374; DM_7289423; FAS; fasn3; FASN[CG17374]; FAS[CG17374]; l(3)80Ff; l(3)Lh4B; l4B
    Summary
    Predicted to enable 3-oxoacyl-[acyl-carrier-protein] synthase activity; oxidoreductase activity; and phosphopantetheine binding activity. Predicted to be involved in fatty acid biosynthetic process. Is expressed in adult head; adult heart; adult oenocyte; and spermatozoon. Orthologous to human FASN (fatty acid synthase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See FASN3 in Genome Data Viewer
    Location:
    80F9-80F9; 3-47 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (25752859..25762779, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3LHet NW_001848857.1 (1135558..1145478, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene loss of visual transmission Neighboring gene pseudo Neighboring gene long non-coding RNA:CR45180 Neighboring gene antisense RNA:CR45182 Neighboring gene lethal (3) 80Fg Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A single gene affects both ecological divergence and mate choice in Drosophila. Chung H, et al. Science, 2014 Mar 7. PMID 24526311
    2. Fatty acid synthase cooperates with glyoxalase 1 to protect against sugar toxicity. Garrido D, et al. PLoS Genet, 2015 Feb. PMID 25692475, Free PMC Article
    3. HP1a targets the Drosophila KDM4A demethylase to a subset of heterochromatic genes to regulate H3K36me3 levels. Lin CH, et al. PLoS One, 2012. PMID 22761891, Free PMC Article
    4. Drosophila HNF4 Directs a Switch in Lipid Metabolism that Supports the Transition to Adulthood. Storelli G, et al. Dev Cell, 2019 Jan 28. PMID 30554999, Free PMC Article
    5. Transcriptional Control of Quality Differences in the Lipid-Based Cuticle Barrier in Drosophila suzukii and Drosophila melanogaster. Wang Y, et al. Front Genet, 2020. PMID 32849846, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables [acyl-carrier-protein] S-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphopantetheine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fatty acid synthase 3
    Names
    CG17374-PC
    FASN3-PC
    lethal (3) 80Ff
    lethal 4B
    lethal4B
    NP_001015405.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      25752859..25762779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001015405.4 → NP_001015405.3  fatty acid synthase 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015405.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7PLB8
      Conserved Domains (12) summary
      cd05195
      Location:1443 → 1734
      enoyl_red; enoyl reductase of polyketide synthase
      cd08954
      Location:1761 → 1988
      KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
      smart00823
      Location:2000 → 2067
      PKS_PP; Phosphopantetheine attachment site
      smart00825
      Location:21 → 421
      PKS_KS; Beta-ketoacyl synthase
      smart00829
      Location:1443 → 1734
      PKS_ER; Enoylreductase
      COG0596
      Location:2120 → 2371
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      cd00833
      Location:19 → 421
      PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
      pfam16197
      Location:383 → 492
      KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension
      cl00509
      Location:877 → 1076
      hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...
      cl08282
      Location:517 → 831
      Acyl_transf_1; Acyl transferase domain
      cl21454
      Location:1301 → 1411
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
      cl21494
      Location:2120 → 2375
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7PLB8 Q7PLB8
    Q8MZH8 Q8MZH8

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