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    Ptth Prothoracicotropic hormone [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33238, updated on 10-May-2024

    Summary

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    Official Symbol
    Ptthprovided by FlyBase
    Official Full Name
    Prothoracicotropic hormoneprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013323
    Locus tag
    Dmel_CG13687
    See related
    AllianceGenome:FB:FBgn0013323
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13687; Dmel\CG13687; ptth; PTTH
    Summary
    Enables prothoracicotrophic hormone activity. Involved in several processes, including negative phototaxis; positive regulation of ecdysteroid biosynthetic process; and torso signaling pathway. Located in varicosity. Is expressed in adult prothoracic gland innervating neuron PG-LP; prothoracic gland innervating neuron PG-LP; and prothoracic gland innervating neurons. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Ptth in Genome Data Viewer
    Location:
    21E2-21E2; 2-1.5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (575711..576896, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (575711..576896, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Splicing factor 3b subunit 1 Neighboring gene Inositol phosphate kinase 2 Neighboring gene coiled Neighboring gene PvuII-PstI homology 13 Neighboring gene Goosecoid Neighboring gene long non-coding RNA:CR46148

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protease cleavage at an engineered tetra-basic motif in Drosophila PTTH accelerates developmental timing. Shimell M, et al. MicroPubl Biol, 2019 Sep 26. PMID 32550412, Free PMC Article
    2. Purification and characterization of the prothoracicotropic hormone of Drosophila melanogaster. Kim AJ, et al. Proc Natl Acad Sci U S A, 1997 Feb 18. PMID 9037018, Free PMC Article
    3. Body size determination in insects: a review and synthesis of size- and brain-dependent and independent mechanisms. Callier V, et al. Biol Rev Camb Philos Soc, 2013 Nov. PMID 23521745
    4. Noggin proteins are multifunctional extracellular regulators of cell signaling. Karunaraj P, et al. Genetics, 2022 May 5. PMID 35357435, Free PMC Article
    5. Injury response checkpoint and developmental timing in insects. Hackney JF, et al. Fly (Austin), 2014. PMID 25833067, Free PMC Article

    See all (122) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ecdysone-dependent feedback regulation of prothoracicotropic hormone controls the timing of developmental maturation.
      Title: Ecdysone-dependent feedback regulation of prothoracicotropic hormone controls the timing of developmental maturation.
    2. PTTH signal contributes to coordination between environmental cues and the developmental program to ensure individual fitness and survival.
      Title: Prothoracicotropic hormone modulates environmental adaptive plasticity through the control of developmental timing.
    3. PTTH controls the decisions of when and where animals undergo metamorphosis, optimizing conditions for adult development.
      Title: Neuroendocrine control of Drosophila larval light preference.
    4. study demonstrates that Torso, is the prothoracicotropic hormone (PTTH) receptor; study concludes that PTTH initiates metamorphosis by activation of the Torso/ERK pathway
      Title: The insect neuropeptide PTTH activates receptor tyrosine kinase torso to initiate metamorphosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables prothoracicotrophic hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prothoracicotrophic hormone activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in metamorphosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative phototaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ecdysteroid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in torso signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in torso signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in varicosity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prothoracicotropic hormone
    Names
    CG13687-PE
    CG13687-PF
    CG13687-PG
    Ptth-PE
    Ptth-PF
    Ptth-PG
    prothoracicotopic hormone

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      575711..576896 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298621.1 → NP_001285550.1  prothoracicotropic hormone, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285550.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V5G9, X2JCX9
      Conserved Domains (1) summary
      pfam06083
      Location:148 → 216
      IL17; Interleukin-17

    2. NM_134693.3 → NP_608537.3  prothoracicotropic hormone, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608537.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V5G9, Q9VPR8
      Conserved Domains (1) summary
      pfam06083
      Location:122 → 190
      IL17; Interleukin-17

    3. NM_001316375.1 → NP_001303304.1  prothoracicotropic hormone, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S0WMK2, Q4V5G9
      Conserved Domains (1) summary
      pfam06083
      Location:114 → 182
      IL17; Interleukin-17
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0S0WMK2 A0A0S0WMK2
    Q24467 Q24467
    Q9VPR8 Q9VPR8
    X2JCX9 X2JCX9

    Gene LinkOut

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