RnrS Ribonucleoside diphosphate reductase small subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: RnrSprovided by FlyBase
Official Full Name: Ribonucleoside diphosphate reductase small subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0011704
Locus tag: Dmel_CG8975
See related: AllianceGenome:FB:FBgn0011704
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.148; CG8975; Dmel\CG8975; DmRNR2; dRNR2; R2; RNR-S; rnr2; Rnr2; RNR2; rnrS; Rnrs; RnRs; RNrS; RNRS
Summary: Predicted to enable ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in activation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to be active in cytosol. Is expressed in several structures, including embryonic/larval nervous system; embryonic/larval tracheal system; extended germ band embryo; gut section; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; mitochondrial DNA depletion syndrome 8b; and pancreatic cancer. Orthologous to several human genes including RRM2 (ribonucleotide reductase regulatory subunit M2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 48D5-48D5; 2-65 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (11983145..11985393, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (7870650..7872898, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in deoxyribonucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in deoxyribonucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ribonucleoside diphosphate reductase small subunit

Names: CG8975-PA; RnrS-PA; ribonucleoside-diphosphate reductase small subunit; ribonucleotide reductase; ribonucleotide reductase small subunit

NP_525111.1

EC 1.-.-.-

EC 1.17.4.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

11983145..11985393 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_080372.4 → NP_525111.1 ribonucleoside diphosphate reductase small subunit [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_525111.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P48592, Q9V640

Related

FBpp0087152

Conserved Domains (1) summary

cl00264
Location:74 → 393

Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins