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    NNMT nicotinamide N-methyltransferase [ Homo sapiens (human) ]

    Gene ID: 4837, updated on 10-Mar-2024

    Summary

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    Official Symbol
    NNMTprovided by HGNC
    Official Full Name
    nicotinamide N-methyltransferaseprovided by HGNC
    Primary source
    HGNC:HGNC:7861
    See related
    Ensembl:ENSG00000166741 MIM:600008; AllianceGenome:HGNC:7861
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in liver (RPKM 188.3), appendix (RPKM 69.3) and 10 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    11q23.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (114257806..114313536)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (114268171..114323905)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (114128528..114184258)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902761 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113906845-113907785 Neighboring gene Sharpr-MPRA regulatory region 6346 Neighboring gene Sharpr-MPRA regulatory region 5585 Neighboring gene zinc finger and BTB domain containing 16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113962252-113962768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113962769-113963283 Neighboring gene MPRA-validated peak1475 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114030299-114030800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114030801-114031300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114034953-114035454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114035455-114035954 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3915 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114083238-114083738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114083739-114084239 Neighboring gene Sharpr-MPRA regulatory region 4637 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114111177-114111676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114128337-114128865 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:114166597-114167097 Neighboring gene uncharacterized LOC101928940 Neighboring gene uncharacterized LOC107984391 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr11:114270475-114271017 and GRCh37_chr11:114271018-114271560 Neighboring gene chromosome 11 open reading frame 71

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Stromal nicotinamide N-methyltransferase orchestrates the crosstalk between fibroblasts and tumour cells in oral squamous cell carcinoma: evidence from patient-derived assembled organoids. Zhao H, et al. Oncogene, 2023 Apr. PMID 36823377
    2. NNMT Is an Immune-Related Prognostic Biomarker That Modulates the Tumor Microenvironment in Pan-Cancer. Liu W, et al. Dis Markers, 2023. PMID 36817086, Free PMC Article
    3. Identification of Biological Functions and Prognostic Value of NNMT in Oral Squamous Cell Carcinoma. Zhang W, et al. Biomolecules, 2022 Oct 15. PMID 36291696, Free PMC Article
    4. Tumor stromal nicotinamide N-methyltransferase overexpression as a prognostic biomarker for poor clinical outcome in early-stage colorectal cancer. Ogawa M, et al. Sci Rep, 2022 Feb 17. PMID 35177765, Free PMC Article
    5. Nicotinamide N-Methyltransferase: An Emerging Protagonist in Cancer Macro(r)evolution. Parsons RB, et al. Biomolecules, 2021 Sep 28. PMID 34680055, Free PMC Article

    See all (119) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NNMT/1-MNA Promote Cell-Cycle Progression of Breast Cancer by Targeting UBC12/Cullin-1-Mediated Degradation of P27 Proteins.
      Title: NNMT/1-MNA Promote Cell-Cycle Progression of Breast Cancer by Targeting UBC12/Cullin-1-Mediated Degradation of P27 Proteins.
    2. NNMT enriches for AQP5[+] cancer stem cells to drive malignant progression in early gastric cardia adenocarcinoma.
      Title: NNMT enriches for AQP5(+) cancer stem cells to drive malignant progression in early gastric cardia adenocarcinoma.
    3. Lipid reprogramming induced by the NNMT-ABCA1 axis enhanced membrane fluidity to promote endometrial cancer progression.
      Title: Lipid reprogramming induced by the NNMT-ABCA1 axis enhanced membrane fluidity to promote endometrial cancer progression.
    4. Nicotinamide N -methyltransferase promotes M2 macrophage polarization by IL6 and MDSC conversion by GM-CSF in gallbladder carcinoma.
      Title: Nicotinamide N -methyltransferase promotes M2 macrophage polarization by IL6 and MDSC conversion by GM-CSF in gallbladder carcinoma.
    5. Proteomics Profiling of Bladder Cancer Tissues from Early to Advanced Stages Reveals NNMT and GALK1 as Biomarkers for Early Detection and Prognosis of BCa.
      Title: Proteomics Profiling of Bladder Cancer Tissues from Early to Advanced Stages Reveals NNMT and GALK1 as Biomarkers for Early Detection and Prognosis of BCa.
    6. Nicotinamide N-methyltransferase mediates lipofibroblast-myofibroblast transition and apoptosis resistance.
      Title: Nicotinamide N-methyltransferase mediates lipofibroblast-myofibroblast transition and apoptosis resistance.
    7. Stromal nicotinamide N-methyltransferase orchestrates the crosstalk between fibroblasts and tumour cells in oral squamous cell carcinoma: evidence from patient-derived assembled organoids.
      Title: Stromal nicotinamide N-methyltransferase orchestrates the crosstalk between fibroblasts and tumour cells in oral squamous cell carcinoma: evidence from patient-derived assembled organoids.
    8. NNMT Is an Immune-Related Prognostic Biomarker That Modulates the Tumor Microenvironment in Pan-Cancer.
      Title: NNMT Is an Immune-Related Prognostic Biomarker That Modulates the Tumor Microenvironment in Pan-Cancer.
    9. Identification of Biological Functions and Prognostic Value of NNMT in Oral Squamous Cell Carcinoma.
      Title: Identification of Biological Functions and Prognostic Value of NNMT in Oral Squamous Cell Carcinoma.
    10. NNMT contributes to high metastasis of triple negative breast cancer by enhancing PP2A/MEK/ERK/c-Jun/ABCA1 pathway mediated membrane fluidity.
      Title: NNMT contributes to high metastasis of triple negative breast cancer by enhancing PP2A/MEK/ERK/c-Jun/ABCA1 pathway mediated membrane fluidity.
    Submit: New GeneRIF Correction See all GeneRIFs (96)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of nicotinamide N-methyltransferase (NNMT) in primary human brain microvascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables nicotinamide N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nicotinamide N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nicotinamide N-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nicotinamide N-methyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables pyridine N-methyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD biosynthesis via nicotinamide riboside salvage pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in animal organ regeneration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation TAS
    Traceable Author Statement
    more info
    		  
    involved_in nicotinamide metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein deacetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to organonitrogen compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    nicotinamide N-methyltransferase
    NP_001358974.1
    NP_001358975.1
    NP_001358976.1
    NP_006160.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001372045.1 → NP_001358974.1  nicotinamide N-methyltransferase

      Status: REVIEWED

      Source sequence(s)
      AP002518
      Consensus CDS
      CCDS8368.1
      UniProtKB/Swiss-Prot
      P40261
      UniProtKB/TrEMBL
      A0A024R3J0, B0YJ53, Q6FH49
      Conserved Domains (1) summary
      pfam01234
      Location:2 → 259
      NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

    2. NM_001372046.1 → NP_001358975.1  nicotinamide N-methyltransferase

      Status: REVIEWED

      Source sequence(s)
      AP002518
      Consensus CDS
      CCDS8368.1
      UniProtKB/Swiss-Prot
      P40261
      UniProtKB/TrEMBL
      A0A024R3J0, B0YJ53, Q6FH49
      Conserved Domains (1) summary
      pfam01234
      Location:2 → 259
      NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

    3. NM_001372047.1 → NP_001358976.1  nicotinamide N-methyltransferase

      Status: REVIEWED

      Source sequence(s)
      AP002518
      Consensus CDS
      CCDS8368.1
      UniProtKB/Swiss-Prot
      P40261
      UniProtKB/TrEMBL
      A0A024R3J0, B0YJ53, Q6FH49
      Related
      ENSP00000441434.1, ENST00000535401.5
      Conserved Domains (1) summary
      pfam01234
      Location:2 → 259
      NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

    4. NM_006169.3 → NP_006160.1  nicotinamide N-methyltransferase

      See identical proteins and their annotated locations for NP_006160.1

      Status: REVIEWED

      Source sequence(s)
      AP002518
      Consensus CDS
      CCDS8368.1
      UniProtKB/Swiss-Prot
      P40261
      UniProtKB/TrEMBL
      A0A024R3J0, B0YJ53, Q6FH49
      Related
      ENSP00000299964.3, ENST00000299964.4
      Conserved Domains (1) summary
      pfam01234
      Location:2 → 259
      NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

    RNA

    1. NR_164073.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP002518

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      114257806..114313536
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      114268171..114323905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40261.1 GenPept UniProtKB/Swiss-Prot:P40261

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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