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    SuUR Suppressor of Under-Replication [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45739, updated on 10-May-2024

    Summary

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    Official Symbol
    SuURprovided by FlyBase
    Official Full Name
    Suppressor of Under-Replicationprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025355
    Locus tag
    Dmel_CG7869
    See related
    AllianceGenome:FB:FBgn0025355
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7869; Dmel\CG7869; Dromel_CG7869_FBtr0076203_suur_mORF; Su(UR); SU(UR); su(UR)ES; Su(UR)ES; SUUR
    Summary
    Enables chromatin binding activity. Involved in several processes, including DNA endoreduplication; chromatin organization; and regulation of DNA-dependent DNA replication. Located in chromosome. Is expressed in several structures, including egg chamber; embryonic Malpighian tubule; embryonic/larval muscle system; and gut section. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See SuUR in Genome Data Viewer
    Location:
    68A4-68A4; 3-34 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11064991..11069025)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11058091..11062125)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Biogenesis of lysosome-related organelles complex 1, subunit 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Molybdenum cofactor synthesis 1 Neighboring gene Prefoldin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Guanine quadruplex structures localize to heterochromatin. Hoffmann RF, et al. Nucleic Acids Res, 2016 Jan 8. PMID 26384414, Free PMC Article
    2. The effects of SUUR protein suggest its role in repressive chromatin renewal during replication in Drosophila. Posukh OV, et al. Nucleus, 2015. PMID 26211696, Free PMC Article
    3. Understanding replication fork progression, stability, and chromosome fragility by exploiting the Suppressor of Underreplication protein. Nordman JT, et al. Bioessays, 2015 Aug. PMID 26059810, Free PMC Article
    4. Incomplete replication generates somatic DNA alterations within Drosophila polytene salivary gland cells. Yarosh W, et al. Genes Dev, 2014 Aug 15. PMID 25128500, Free PMC Article
    5. Late replication domains are evolutionary conserved in the Drosophila genome. Andreyenkova NG, et al. PLoS One, 2013. PMID 24391753, Free PMC Article

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Organization of Pericentromeric Heterochromatin in Polytene Chromosome 3 of the Drosophilamelanogaster Line with the Rif1(1); SuUR(ES) Su(var)3-9(06) Mutations Suppressing Underreplication.
      Title: The Organization of Pericentromeric Heterochromatin in Polytene Chromosome 3 of the Drosophilamelanogaster Line with the Rif1(1); SuUR(ES) Su(var)3-9(06) Mutations Suppressing Underreplication.
    2. Recruitment of either HP1(GAL4DBD) or SUUR(GAL4DBD) resulted in delayed completion of replication
      Title: Tethering of SUUR and HP1 proteins results in delayed replication of euchromatic regions in Drosophila melanogaster polytene chromosomes.
    3. SUUR protein binding correlates with gene regulation and specific chromatin types.
      Title: Developmental variation of the SUUR protein binding correlates with gene regulation and specific chromatin types in D. melanogaster.
    4. Our findings support the idea that the effect of SUUR on replication elongation depends on the cell cycle stage and can be mediated through its physical interaction with replication fork.
      Title: Drosophila SUUR protein associates with PCNA and binds chromatin in a cell cycle-dependent manner.
    5. the SUUR protein is required for the SU(VAR)3-9 enzyme to bind to the salivary gland polytene chromosomes
      Title: The SUUR protein is involved in binding of SU(VAR)3-9 and methylation of H3K9 and H3K27 in chromosomes of Drosophila melanogaster.
    6. Mutation of two conserved amino acid residues in this region impairs binding of SUUR to polytene chromosomes and reduces the ability of the protein to cause DNA underreplication.
      Title: Conservation of domain structure in a fast-evolving heterochromatic SUUR protein in drosophilids.
    7. Suppressor of Underreplication gene does not directely affect the replication progression
      Title: The mutation of the Suppressor of Underreplication gene does not affect the replication fork rate in the Drosophila melanogaster salivary gland polytene chromosomes.
    8. Reversible decondensation of heterochromatin regions of polytene chromosomes during ectopic expression of the SuUR gene.
      Title: Reversible decondensation of heterochromatin regions of Drosophila melanogaster polytene chromosomes during ectopic expression of the SuUR gene.
    9. it is proposed that interaction of SUUR with HP1 is crucial for the association of SUUR with chromatin
      Title: Interaction between the Drosophila heterochromatin proteins SUUR and HP1.
    10. these results suggest that SUUR is a ubiquitous marker of heterochromatin in different cell types
      Title: SUUR joins separate subsets of PcG, HP1 and B-type lamin targets in Drosophila.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA replication IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in chromatin organization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of protein location IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA replication TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to chromosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of intercalary heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear replication fork IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    suppressor of Under-Replication
    Names
    CG7869-PA
    SuUR-PA
    suppressor of Under- replication
    suppressor of underreplication
    suppressor of underreplication protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11064991..11069025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080096.3 → NP_524835.1  suppressor of Under-Replication [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524835.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9N6U5, Q9VTE2
      Related
      FBpp0075933
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTE2.3 Q9VTE2

    Gene LinkOut

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